Multiple Sclerosis,
In a subset of multiple sclerosis
(MS) patients antibodies against myelin antigens seem to be important in
the demyelinating process.
In this study we investigated IgM,
IgA and IgG serum antibodies against the myelin oligodendrocyte glycoprotein
(MOG) and the myelin basic protein (MBP) in 261 MS patients.
Seventy-two per cent had anti-MOG
antibodies, 59% were anti-MBP seropositive.
The dominating antibody was anti-MOG
IgM. A significant relationship between IgA and a progressive disease course
was found.
The predominance of IgG1 together
with the significantly associated occurrence of IgG3 against MOG corresponds
to the prevailing IgG1 and IgG3 isotypes in other autoimmune diseases.
Patients who actually suffered from
a relapse were significant more often anti-MOG and anti-MBP IgG3 seropositive
than those in remission.
However, patients treated either
with intravenous immunoglobulins or interferon-b
showed a significant reduction of anti-MOG IgG3 antibodies.
© 2001 ingenta
October 2001, vol. 7, no. 5,
pp. 285-289(5)
Egg R. [1]; Reindl M. [1]; Deisenhammer
F. [1]; Linington C. [2]; Berger T. [1] *
[1] Department of Neurology, University
of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria
[2] Department of Neuroimmunology,
Max Planck Institute for Neurobiology, D-82152 Martinsried, Germany
[*] Correspondence: T Berger, University
of Innsbruck, Department of Neurology, Anichstraße 35, A-6020 Innsbruck,
Austria
Abstract: