May 21st, 2004
Boston Cure Project
Some of you may know of the research looking at whether raising blood levels of uric acid by means of a common nutritional supplement, Inosine, is effective in controlling MS. The theory behind this work is quite interesting--an epidemiological investigation showing that MS and gout appear to be mutually exclusive. Since gout is caused by uric acid levels which are too high, the theory is that MS is caused by uric acid levels which are too low. Inosine supplementation can raise uric acid levels.
A small phase 1 trial appeared promising. In this NIH-funded study Phase II trial, they raise the blood level of uric acid by administering inosine doses increasing from 1 to 3 g/day. The goal is to get serum UA levels to approximately 8 mg/dl; thereafter, a lower dose of inosine is given sufficient to maintain serum UA levels within a range of 7 ± 9 mg/dl.
At the recent AAN meeting, one other study reported positive results
along this same line of research. An
Italian study showed a decrease in relapses for the treated group,
but with a twist--some patients showed decreasing uric acid levels even
with the inosine supplementation. If I read this correctly, the subgroup
whose uric acid levels did not rise had relapses, while the subgroup who
responded to the inosine with elevated uric acid levels did not have any
Copyright © 2004, Boston Cure Project