Neurosci Lett. 2004 Jun 3;363(1):14-7
Martinez-Yelamos A, Saiz A, Bas J, Hernandez JJ, Graus F, Arbizu T.
Department of Neurology, Hospital de Viladecans, Av. Gava 380 08840 Viladecans, Barcelona, Spain.
We analyzed the prognostic value of Tau protein, a marker of axonal damage, detected in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS).
We sampled the CSF from 32 patients with probable or definite RRMS, having had the disease for less than 5 years.
We studied the relationship between Tau protein concentration in the CSF (CSF-TAU) and disability, time to next relapse and time to experience a one point increase on the Expanded Disability Status Scale (EDSS).
CSF-TAU was correlated with the Progression Index at the end of follow-up.
Patients with higher CSF-TAU experienced a more rapid one point increase in the EDSS.
CSF-TAU was the only independent variable to predict the time to next relapse.
CSF-TAU, as a marker of axonal loss, may help us to predict short-term outcome in patients with early RRMS.