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More MS news articles for May 2004

Involvement of insulin-like growth factor binding protein-2 in activated microglia as assessed in post mortem human brain

Neurosci Lett. 2004 May 13;362(1):14-6
Chesik D, De Keyser J, Wilczak N.
Department of Neurology, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

In vitro studies suggest that insulin-like growth factor (IGF)-I is a mitogen for microglia/macrophages.

The actions of IGF-I are mediated by IGF-I receptors and modulated by IGF binding proteins (IGFBPs).

The aim of this study was to investigate IGF-I receptors and IGFBPs in human microglia in normal brain white matter and active lesions of multiple sclerosis, which contain activated microglia/macrophages.

Methods used were immunohistochemistry and confocal laser microscopy.

IGF-I receptors were demonstrated in both resting and activated microglia.

In resting conditions, microglia displayed no immunoreactivity for any of the six IGFBPs, whereas activated microglia/macrophages were immunoreactive for IGFBP-2 only.

Our data suggest an important function for IGFBP-2 in IGF-I actions in activated microglia/macrophages in human brain.