Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2003 Jul;19(4):387-9
Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China.
By investigating the effects of APLs of PLP(136-150) on T cell clone 4B.14a in-vitro and in-vivo, to determine the feasibility of APLs to prevent relapsing multiple sclerosis (MS) in human.
To mimic the clinic course of relapsing MS, SJL/J female mice were first irradiated at 450R and intravenously infused with 1x10(7) resting 4B.14a T cells per mouse.
Then mice were immunized with 50 microg/mouse APL for inducing passive experiment allergic encephalomyelitis (EAE).
The proliferation and cytokine production of 4B.14a T cells in response to APLs were also examined.
Except 139A, 143A, 144A, 145A and 148A, other APLs triggered T cells to induce passive EAE; 4B.14a T cells well responded to the most APLs, weakly responded to 137A, 144A and 148A, but the response was suppressed by 139A.
The effects of some APLs on 4B.14a T cells are different in-vitro and in-vivo.
It may be feasible to select some APLs to prevent relapsing MS in human.