Acta Neurol Scand. 2004 Jun;109(6):390-2
Bartosik-Psujek H, Belniak E, Mitosek-Szewczyk K, Dobosz B, Stelmasiak
Z.
Department of Neurology, Medical University, Lublin, Poland
OBJECTIVE:
Chemokines are involved in the pathogenesis of multiple sclerosis.
The aim of the study was to evaluate the effects of immunosuppressive therapy on production of two proinflammatory chemokines--interleukin-8 (IL-8) and RANTES (regulated on activation, normal T cell expressed and secreted).
MATERIALS AND METHODS:
Twenty-five patients with relapsing-remitting multiple sclerosis were treated with 2-chlorodeoxyadenosine (Cladribine), administered subcutaneously in 6 cycles repeated every 5 weeks.
IL-8 and RANTES levels were measured by the enzyme-linked immunoassay (ELISA) method in serum and cerebrospinal fluid (CSF) before and after treatment.
RESULTS:
After Cladribine treatment the levels of IL-8 decreased significantly in CSF only, whereas the RANTES levels decreased significantly both in CSF and serum.
CONCLUSION:
Our results suggest that Cladribine therapy might modify the circulating level of RANTES.