Clin Neurophysiol. 2004 Jun;115(6):1473-1478
Saari A, Tolonen U, Paakko E, Suominen K, Pyhtinen J, Sotaniemi K, Myllyla V V.
Department of Neurology, Oulu University Hospital, P.O. Box 25, 90029 OYS, Oulu, Finland.
The aim of the present study was to investigate the cardiovascular autonomic control in clinically definite multiple sclerosis (MS) patients with a standardised battery of cardiovascular tests and to correlate these findings with the brain magnetic resonance imaging (MRI) lesion load.
Fifty-one patients with MS and 50 healthy controls were studied.
Brain MRI was performed in all patients showing typical MS lesions.
The cardiovascular tests were carried out using a standardised battery.
Heart rate (HR) responses to deep breathing [Formula: see text] and tilt table testing [Formula: see text] were significantly decreased in MS patients when compared to those of the controls.
Blood pressure (BP) responses in the tilt table test were also impaired in MS patients (diastolic [Formula: see text] systolic [Formula: see text] ).
Of the different brain areas investigated the total volume of the midbrain MRI lesions [Formula: see text] was the one most clearly associated with the impaired BP responses.
MS results in both reduced HR variation and decreased BP reactions indicating disturbed cardiovascular regulation.
In particular, the midbrain lesions found in MS are associated with cardiovascular dysfunction.