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More MS news articles for May 2004

Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15134718

Clin Neurophysiol. 2004 Jun;115(6):1473-1478
Saari A, Tolonen U, Paakko E, Suominen K, Pyhtinen J, Sotaniemi K, Myllyla V V.
Department of Neurology, Oulu University Hospital, P.O. Box 25, 90029 OYS, Oulu, Finland.

OBJECTIVE:

The aim of the present study was to investigate the cardiovascular autonomic control in clinically definite multiple sclerosis (MS) patients with a standardised battery of cardiovascular tests and to correlate these findings with the brain magnetic resonance imaging (MRI) lesion load.

METHODS:

Fifty-one patients with MS and 50 healthy controls were studied.

Brain MRI was performed in all patients showing typical MS lesions.

The cardiovascular tests were carried out using a standardised battery.

RESULTS:

Heart rate (HR) responses to deep breathing [Formula: see text] and tilt table testing [Formula: see text] were significantly decreased in MS patients when compared to those of the controls.

Blood pressure (BP) responses in the tilt table test were also impaired in MS patients (diastolic [Formula: see text] systolic [Formula: see text] ).

Of the different brain areas investigated the total volume of the midbrain MRI lesions [Formula: see text] was the one most clearly associated with the impaired BP responses.

CONCLUSIONS:

MS results in both reduced HR variation and decreased BP reactions indicating disturbed cardiovascular regulation.

In particular, the midbrain lesions found in MS are associated with cardiovascular dysfunction.