Genes Immun 2003 Jun;4(4):312-5
Caillier S, Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman
L, Martin E, Haines JL, Pericak-Vance M, Hauser SL, Oksenberg JR.
Department of Neurology, University of California, San Francisco, CA,
USA.
Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS).
Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients.
Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS.
Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course.
Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.