J Neuroimmunol 2003 May;138(1-2):106-14
Vos CM, van Haastert ES, de Groot CJ, van der Valk P, de Vries HE.
Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS).
We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages.
In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected.
In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive.
A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions.
This suggests a role for MMP-12 during demyelination in MS.