More MS news articles for May 2002

The Wistar Kyoto (RT1(l)) rat is resistant to myelin basic protein-induced experimental autoimmune encephalomyelitis: comparison with the susceptible Lewis (RT1(l)) strain with regard to the MBP-directed CD4(+) T cell repertoire and its regulation

J Neuroimmunol 2002 May;126(1-2):25-36
Stevens DB, Gold DP, Sercarz EE, Moudgil KD.
Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, 92121, San Diego, CA, USA

Here, we demonstrate that the Wistar Kyoto (WKY/NHsd) rat, which bears the same RT1(l) haplotype as the experimental autoimmune encephalomyelitis (EAE)-susceptible Lewis rat strain, is highly resistant to myelin basic protein (MBP)-induced EAE.

No differences between Lewis and WKY strains were found in T cell proliferative specificity or the use of Vbeta8.2 T cell receptors in response to MBP.

A Th2 cytokine bias correlated with WKY's EAE resistance.

MBP challenge of WKY-into-Lewis adoptive transfer recipients produced a novel biepisodic EAE.

The WKY strain should be useful in studies of many tissue-specific autoimmune diseases to which the Lewis rat is susceptible.