More MS news articles for May 2002

Monocyte/macrophage initiation of organ-specific autoimmunity: the ultimate 'bystander' hypothesis?

Med Hypotheses 2002 Apr;58(4):312-26
Stoy NS.
Royal Hospital for Neuro-disability, West Hill, Putney, London, UK

It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically.

Failure of regulation of pro-inflammatory monocytes/macrophages might then result in autoimmune disease if secondary over-expansion of pre-existing autoantigen-specific T cell populations occurs in genetically predisposed individuals.

Copyright 2002 Elsevier Science Ltd.