Med Hypotheses 2002 Apr;58(4):312-26
Royal Hospital for Neuro-disability, West Hill, Putney, London, UK
It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically.
Failure of regulation of pro-inflammatory monocytes/macrophages might
then result in autoimmune disease if secondary over-expansion of pre-existing
autoantigen-specific T cell populations occurs in genetically predisposed
Copyright 2002 Elsevier Science Ltd.