More MS news articles for May 2002

Targeting monocyte recruitment in CNS autoimmune disease

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12027417&dopt=Abstract

Clin Immunol 2002 May;103(2):125-31
Izikson L, Klein RS, Luster AD, Weiner HL.
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, 02115

Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases.

Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS).

Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.

(c) 2002 Elsevier Science (USA).