Clin Immunol 2002 May;103(2):125-31
Izikson L, Klein RS, Luster AD, Weiner HL.
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, 02115
Monocytes and macrophages play a pathogenic role in a number of autoimmune inflammatory diseases.
Recent studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have identified a critical chemokine-mediated mechanism of monocyte homing to the central nervous system (CNS).
Here, we summarize the current findings in EAE, develop a rationale for targeting the chemokine axis in order to treat CNS inflammatory disease, and review currently available molecule-specific therapeutics that inhibit monocyte trafficking to the CNS.
(c) 2002 Elsevier Science (USA).