More MS news articles for May 2002

Safety, tolerability, and efficacy of orally administered cannabinoids in MS

Neurology 2002 May 14;58(9):1404-7
Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH.
Department of Neurology, VU Medical Center, Amsterdam, the Netherlands.

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract.

Both drugs were safe, but adverse events were more common with plant-extract treatment.

Compared with placebo, neither THC nor plant-extract treatment reduced spasticity.

Both THC and plant-extract treatment worsened the participant's global impression.