Neurology 2002 May 14;58(9):1415-8
Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S.
Third Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
The effect of corticosteroid on the concentration of amyloid beta-peptide (Abeta) in human CSF obtained from 16 patients without dementia treated with prednisolone (> or =30 mg daily) was studied.
The concentrations of Abetax-40 and Abetax-42 in CSF decreased after treatment was started (p < 0.002).
A moderate- or high-dose regimen of prednisolone decreases Abeta production or increases Abeta degradation in the human brain and deserves further study in AD.