Volume 144 Issue 4 (2002) pp 365-368
F. Batay (1), O. Al-Mefty (2)
(1) Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
(2) Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Although multiple sclerosis (MS) is a common disease of the central nervous system, the association of intraparenchymal tumour has been rarely reported and the potential relationship between intracranial meningioma and MS has not been seriously analysed. This report addresses the association of multiple sclerosis and intracranial meningioma and discusses the effect of interferon treatment on tumour progression.
We report two cases with multiple sclerosis, who developed meningioma four and twenty years after the diagnosis of MS was made. Neither patient had a history of meningioma initially and both were being treated interferon when the meningioma was progressed.
Histological examination of two cases revealed meningothelial meningioma. The first patient's KI67 level was 2.5% and was positive for the progesterone and estrogen receptor. Chromosomal analysis showed some abnormalities. In the second case, mild atypical change by presence of nuclear enlargement and rare mitotic figures were noted and PCNA, KI67 levels were less than 2%.
We reported the association of multiple sclerosis and intracranial meningioma
and observed the progression of the meningiomas during interferon treatment.
Although, we cannot exclude the coincidence between the two diseases we
discussed suspicious relationship between the interferon treatment and
the tumour progression.
© Springer-Verlag Wien 2002