More MS news articles for May 2002

Determination of medullasin levels for the diagnosis of multiple sclerosis

Rinsho Byori 2002 Mar;50(3):308-12
Aoki Y, Saida T, Nakano I, Saito T, Ikeguchi K, Urabe T, Nishiguchi E, Suzuki H, Takahashi K, Mizuno Y.
Department of Food and Health Science, Faculty of Human Life Science, Jissen Women's University, Hino 191-8510.

Medullasin levels in granulocytes of patients with neurological diseases and healthy volunteers were determined by the enzyme immunoassay using mouse monoclonal antibodies against human medullasin and o-phenylenediamine-H2O2 as the detection system of the enzyme activity

One hundred twenty-one out of 159 patients with multiple sclerosis (76.1%) showed positive results (above means of normals + 2SD) in this test, while only 16.9% (24/142) of patients with non-inflammatory neurological diseases had positive results

This enzyme immunoassay method for medullasin is considered to be an useful paraclinical test for the diagnosis of multiple sclerosis.