Layh-Schmitt G, Bendl C, Hildt U, Dong-Si T, Juttler E, Schnitzler P, Grond-Ginsbach C, Grau AJ.

Ann Neurol 2000
May;47(5):652-5

Department of Microbiology, University of Heidelberg, Germany.

In a pilot study, we identified Chlamydia pneumoniae in the cerebrospinal  fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (MS). In a second series, 2 of 20 patients with definite MS and 3 of 17 patients with possible/probable MS or MS variants, but none of 56 patients with other neurological, diseases were polymerase chain reaction-positive. We confirm that C. pneumoniae can be found in the cerebrospinal fluid of MS patients, but our rate of positive results is lower than in a recent report.

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Other publications on C.p. and MS:

Treib et al.  Multiple sclerosis and Chlamydia pneumoniae. Ann Neurol 2000 Mar;47(3):408; discussion 409-11.

Heinzl S. Chlamydia, atherosclerosis, asthma and MS.  Med Monatsschr Pharm 2000 Feb;23(2):37.

Boman et al.  Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS.  Neurology 2000 Jan 11;54(1):265.
 
Stratton CW, Mitchell WM, Sriram S.  Does Chlamydia pneumoniae play a role in  the pathogenesis of multiple sclerosis? J Med Microbiol 2000 Jan;49(1):1-3

Sriram et al. Chlamydia pneumoniae infection of the central nervous system in  multiple sclerosis.  Ann Neurol 1999 Jul;46(1):6-14

Sriram S, Mitchell W, Stratton C.  Multiple sclerosis associated with  Chlamydia pneumoniae infection of the CNS.  Neurology 1998 Feb;50(2):571-2