J Neuroimmunol. 2004 Apr;149(1-2):202-9
Jensen J, Langkilde AR, Fenst C, Nicolaisen MS, Roed HG, Christiansen
M, Sellebjerg F.
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup
Hospital, Glostrup DK-2600, Denmark.
We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis.
The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity.
In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands.
These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients.