Br J Radiol. 2004 Feb;77(914):153-6
Tan HM, Chan LL, Chuah KL, Goh NS, Tang KK.
Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 168609.
The characteristic clinicoradiological findings of multiple sclerosis and acute disseminated encephalomyelitis (ADEM), demonstrating a recurrent progressive course in the former and monophasicity in the latter associated with multiple discrete white matter lesions with variable enhancement on MRI, are not a diagnostic challenge.
On the other hand, the less typical radiological presentation of a solitary tumefactive demyelinating lesion mimics a neoplasm, and often necessitates a biopsy.
Nonetheless, histopathological examination is an imperfect gold standard and the recognition of certain imaging features may facilitate the correct diagnosis.