Arch Neurol. 2004 Mar;61(3):366-8
Mezzapesa DM, Rocca MA, Falini A, Rodegher ME, Ghezzi A, Comi G, Filippi M.
Neuroimaging Research Unit and the Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy.
Early-onset multiple sclerosis (MS) typically has a more favorable course than adult-onset disease.
To assess the extent of microscopic tissue damage in the brain and cervical cord of patients with early-onset MS.
During a single magnetic resonance imaging session, images of the brain and spinal cord were obtained using diffusion tensor and magnetization transfer magnetic resonance imaging.
We studied 13 patients with early-onset MS and 10 healthy volunteers.
Compared with control subjects, patients with early-onset MS showed only a slight increase of the average mean diffusivity of the normal-appearing brain tissue.
The relatively modest central nervous system damage detected in these patients might explain why early-onset MS typically has a more favorable clinical course than adult-onset MS.