J Neurol. 2004 Mar;251(3):279-83
Karabudak R, Kurne A, Guc D, Sengelen M, Canpinar H, Kansu E.
Hacettepe University, Faculty of Medicine, Department of Neurology Neuroimmunology Unit, 06100, Ankara, Turkey
There is emerging evidence that matrix metalloproteinases (MMPs) might be involved in blood brain barrier (BBB) breakdown in multiple sclerosis.A group of natural tissue inhibitors of metalloproteinases (TIMPS) regulates proteolytic activity to prevent tissue damage.
TIMP-1 and MMP-9 are known to be secreted as heterodimers and TIMP-1 preferentially functions to inhibit MMP-9 activity.
In this present study, the effects of IFNbeta-1a on serum MMP-9 and TIMP-1 were evaluated longitudinally during a one-year period.
The MMP-9 levels showed no significant changes while TIMP-1 levels gradually and significantly increased during 3(rd) and 6(th) months of therapy compared with pretreatment levels.