Neurology. 2004 Mar 9;62(5):811-4
Kantarci OH, Hebrink DD, Achenbach SJ, Pittock SJ, Altintas A, Schaefer-Klein JL, Atkinson EJ, De Andrade M, McMurray CT, Rodriguez M, Weinshenker BG.
Departments of Neurology, Health Sciences Research, Neuroscience Program, Mayo Clinic and Foundation, Rochester, MN, USA.
The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts.
Women carriers of the E4*epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009).
There was no association in men.
Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.