March 29th, 2004
Boston Cure Project
Two prominent MS scientists, Hans Lassmann and Richard Ransohoff, have
published a critique
of the CD4+ T-cell driven model of autoimmunity that is so widely used
in the study of MS. They argue that none of the predictions made by this
model can be fully substantiated by the available evidence from the disease.
For instance, they claim that the model does not account for the role and
presence of CD8+ T cells in MS lesions, that predictions about the effect
of cytokines such as TNF-alpha have been contradicted in clinical trials,
and that the model fails to explain all of the neurodegeneration that takes
place in MS. The authors recommend thinking about MS not as a single-mechanism
disease but instead as a likely heterogeneous disease in which immune system
components play a variety of roles, both helpful and harmful, at different
times in conjunction with other factors.
Copyright © 2004, Boston Cure Project