http://www.nationalmssociety.org/pdf/research/GrantsList.pdf
Spring 2004
Research Programs Department
National Multiple Sclerosis Society
[To give a better idea of which areas the NMSS
research grants are concentrated, I have taken the liberty of analysing
the number of projects per stated category. This is shown in the following
table:
| Category | Number of Projects |
| Biochemistry/Biophysics | 3 |
| Biology of Glia | 63 |
| CNS Repair | 18 |
| Diagnostic Methods | 1 |
| Epidemiology | 3 |
| Health Care | 8 |
| Human Genetics | 12 |
| Immunology | 119 |
| Infectious Agents | 7 |
| MS Therapy/Management | 1 |
| Measuring Disease Activity | 2 |
| Measuring MS Disease | 11 |
| Neuropathology | 18 |
| Neuropharmacology | 1 |
| Neurophysiology | 6 |
| Psychosocial Aspects of MS | 13 |
| Rehabilitation | 10 |
| Therapy/Management of MS | 13 |
| Tissue/DNA Banks | 2 |
| Total | 311 |
Introduction
This document lists, by state and country, all current MS research projects being funded by the National Multiple Sclerosis Society as of April 1, 2004.
Key
The project number for each project is preceded by a program code, as follows:
RG full grants for basic, clinical and rehabilitation research;You will find for selected projects an indication of restricted support that has been provided from individuals, groups, families, or chapters to underwrite the project. This is listed in italic typeface directly beneath the project title. It is through the generous support of individual donors and National MS Society chapters that the Society funds more MS research, offers more services for people with MS, and provides more professional education programs than any other MS organization in the world.
RD full grants co-funded by a collaborative funding agreement with NIH to support a targeted research initiative on gender differences in MS;
CA Collaborative MS Research Center Awards - five-year awards to help stimulate creativity and interaction among investigators working within and outside MS fields;
TA career transition fellowships, awards to facilitate the advancement of promising young investigators into full faculty positions;
FG & FA postdoctoral fellowships, advanced postdoctoral fellowships, respectively research projects by young or more advanced investigators, working under the mentorship of senior scientists, to provide training and experience in MS research;
FP physician fellowships, young doctors working under the mentorship of seasoned clinicians, to provide training and experience in conducting clinical trials in people with MS;
JF Harry Weaver Neuroscience Scholarships special five-year projects by promising young investigators just starting their careers as independent researchers;
PP high-risk pilot research grants, aimed at exploring new, untested ideas;
HC health care delivery and policy contracts initiated by the Society and awarded on a competitive basis to investigators studying subjects identified as mission priorities.
PROJECTS BY STATE AND CHAPTER TERRITORY
ALABAMA
ARKANSAS
CALIFORNIA
COLORADO
CONNECTICUT
DISTRICT OF COLUMBIA
FLORIDA
GEORGIA
ILLINOIS
IOWA
KANSAS
KENTUCKY
MARYLAND
MASSACHUSETTS
MICHIGAN
MINNESOTA
MISSOURI
NEBRASKA
NEW HAMPSHIRE
NEW JERSEY
NEW MEXICO
NEW YORK
NORTH CAROLINA
OHIO
OREGON
PENNSYLVANIA
SOUTH DAKOTA
TENNESSEE
TEXAS
UTAH
VERMONT
VIRGINIA
WASHINGTON
WISCONSIN
INTERNATIONAL GRANTS
Project Number: RG 2667B8/1T
Funding: $354,506
Term: 10/1/01 to 9/30/04
Category: Measuring Disease Activity
p-Cresol sulfate and MS
Developing a lab test of body fluids that may permit monitoring of a person's MS disease activity.
Project Number: FG 1501-A-1
Funding: $120,382
Term: 12/1/02 to 11/30/05
Category: Immunology
Defining the roles of P-and E-selectin during CD4 T cell migration
How specific molecules help escort damaging immune cells into the brain and spinal cord in MS-like disease, for insights into preventing disease.
Project Number: RG 3198A1/1
Funding: $330,000
Term: 4/1/01 to 3/31/05
Category: Biology of Glia
Female sex steroids: effects on glia
Determining mechanisms by which certain sex hormones may protect myelin-making cells.
Project Number: RG 2705C3/1
Funding: $359,276
Term: 10/1/02 to 9/30/05
Category: Biology of Glia
Developmental control of myelin proteolipid protein gene regulation
Exploring genetic factors that dictate the development of a specific protein in nerve-insulating myelin, for clues to stimulating myelin repair in MS.
Project Number: RG 3370A1/T
Funding: $217,413
Term: 10/1/03 to 9/30/05
Category: CNS Repair
Fibrin in demyelination and remyelination
Exploring whether fibrin, a molecule found in MS brain lesions, may inhibit myelin repair, and whether its activity can be reversed to foster recovery.
Project Number: RG 2553D5/1
Funding: $457,885
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
The development of nodes of Ranvier in the central nervous system
Understanding how myelin-making cells influence nerve fiber development, for clues to restoring nerve conduction in MS.
Project Number: FG 1454-A-1
Funding: $111,120
Term: 8/1/01 to 7/31/04
Category: Immunology
Therapy of autoimmune diseases by lymphocyte potassium channel blockers
Determining whether blocking ion channels in immune cells can improve MS-like disease in mice.
Project Number: RG 2693-C-6
Funding: $132,915
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Golli MBP gene expression in the nervous system
Studying the functions of a specific protein that may be involved in the growth, destruction and regeneration of nerve-insulating myelin.
Funded in full by a gift from the NMSS Southern California Chapter
Project Number: RG 3343-A-2
Funding: $389,410
Term: 4/1/02 to 3/31/05
Category: Immunology
Lymphocyte ion channel: novel therapeutic targets for multiple sclerosis
Attempting to stop MS-like disease by blocking pore-like ion channels on the surface of immune cells that target myelin.
Project Number: FP 1430A1/1
Funding: $120,000
Term: 8/1/02 to 7/31/05
Category: MS Therapy/Management
Sylvia Lawry Physician Fellowship
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: FA 1552-A-1
Funding: $154,745
Term: 8/1/03 to 7/31/06
Category: Immunology
Molecular regulation of TIMP-1 gene expression and its role in CNSinflammation
Understanding molecular signals that may help to control active players in the inflammation that occurs in MS-like disease in mice.
Project Number: RG 3338-A-1
Funding: $311,365
Term: 4/1/02 to 3/31/05
Category: Immunology
Protective role of STAT1 in EAE development
How a signaling molecule may prevent MS-like disease and its symptoms, and how it influences immune activity, for clues to new approaches to treating MS.
Project Number: FA 1551-A-1
Funding: $154,745
Term: 3/1/04 to 2/28/07
Category: Infectious Agents
The characterization of T cell responses and immuno-pathology during latentcoxsackievirus infection in the CNS
Identifying the role of a virus in triggering an immune attack and myelin damage in the central nervous system, as a possible model of what occurs in MS.
Project Number: PP0916
Funding: $44,000
Term: 5/1/03 to 4/30/04
Category: Infectious Agents
in vivo models for replication and pathogenesis of human herpes virus
Investigating a possible role for herpesvirus in the development of myelin damage such as that which occurs in MS.
Project Number: RG 3438-A-7
Funding: $258,213
Term: 4/1/03 to 3/31/05
Category: Measuring MS Disease Activity
Pathophysiological significance of autoantibodies to myelin
Characterizing immune antibodies that play a role in the destruction of nerve-insulating myelin in MSlike disease.
Project Number: RG 3320-A-3
Funding: $505,178
Term: 9/30/01 to 9/30/04
Category: Immunology
Molecular analysis of demyelinating antibody responses in EAE
Characterizing immune antibodies that play a role in the destruction of nerve-insulating myelin in MSlike disease.
Project Number: PP0927
Funding: $44,000
Term: 7/1/03 to 6/30/04
Category: Rehabilitation
Locomotor training using body weight support on a treadmill in people with MS
Investigating the effectiveness of an exercise regimen in improving mobility in MS.
Project Number: RG 3405A3/1
Funding: $449,783
Term: 10/1/03 to 9/30/06
Category: Neurophysiology
Mechanisms of sodium channel localization in neuronal cells
Understanding tiny pores on the surface of nerve cells that aid nerve signaling, and how MS alters them.
Project Number: FA 1498-A-1
Funding: $101,003
Term: 8/1/02 to 10/31/04
Category: Immunology
Regulation of T lymphocyte function through the a4 cytoplasmic domain
Understanding the role of a molecule on the surface of immune T cells in the development of MS.
Project Number: RG 2899-B-7
Funding: $1,334,708
Term: 4/1/02 to 3/31/07
Category: Human Genetics
Establishment of a core DNA repository for multiple sclerosis
Collecting genetic material from individuals and from families with multiple members who have MS, as a shared resource for studies searching for genes that confer susceptibility to MS.
Project Number: RG 3240A1/1
Funding: $656,018
Term: 9/30/01 to 9/30/06
Category: Neuropathology
Diffusion tensor imaging in multiple sclerosis
Exploring the potential of a novel imaging technology in people in the earliest stages of MS.
Project Number: FG 1481-A-1
Funding: $142,771
Term: 8/1/02 to 7/31/05
Category: Psychosocial Aspects of MS
Early detection of neuropsychological and psychiatric symptom in multiplesclerosis
Determining the presence of cognitive and emotional symptoms early in the course of MS, to improve their detection and treatment.
Project Number: RG 2765B3/T
Funding: $399,963
Term: 10/1/02 to 9/30/05
Category: Immunology
T cell receptor peptide-specific T cells in regulation of murine EAE
Exploring immune-system mechanisms involved in turning off the immune attack in MS-like disease in mice, for their potential role in treating MS.
Project Number: FG 1562-A-1
Funding: $111,984
Term: 12/1/03 to 11/30/05
Category: Immunology
Molecular and functional heterogeneity of the MOG antibody repertoires
Understanding how immune responses focused against a specific protein in myelin may contribute to the development of MS.
Project Number: RG 3278-A-3
Funding: $236,801
Term: 9/30/01 to 9/30/04
Category: Immunology
Chemokines & chemokine receptors and their roles in viral-induceddemyelination
Investigating factors that regulate how immune cells invade the central nervous system in MS-like disease.
Project Number: FG 1434-A-1
Funding: $120,375
Term: 1/1/02 to 12/31/04
Category: CNS Repair
The identification of novel CNS myelin-associated proteins that inhibit axonoutgrowth
Looking for proteins in nerve fiber-insulating myelin that may inhibit the regeneration of nerve fibers in MS.
Funded in full by a gift from the Alan Buegeleisen Research Fund, in honor of Sylvia Lawry
Project Number: FG 1476-A-1
Funding: $143,860
Term: 10/1/01 to 9/30/04
Category: Immunology
Structural basis for antibody responses to myelin/oligodendrocyte glycoprotein
Characterizing the molecular structure and immune response to a protein in myelin that may be a target for the immune attack in MS.
Project Number: FG 1514-A-1
Funding: $141,771
Term: 8/1/02 to 7/31/05
Category: Measuring MS Disease Activity
T2 relaxation time measurement of spinal cord & brain for people with MS
Developing and applying new ways to analyze imaging techniques to study spinal cord damage in persons with MS.
Project Number: RG 2901C6/1
Funding: $401,194
Term: 4/1/04 to 3/31/06
Category: Human Genetics
Genetic mapping in multiple sclerosis
Attempting to pinpoint genes that may be involved in determining MS susceptibility, progression and other disease characteristics.
Project Number: RG 3060-B-5
Funding: $363,888
Term: 10/1/02 to 9/30/05
Category: Human Genetics
Family-based genetic studies in ethnically distinct MS population
Searching for MS susceptibility genes by studying genetic material from families with distinct ethnic backgrounds.
Project Number: FG 1494-A-1
Funding: $107,462
Term: 8/1/02 to 7/31/05
Category: Immunology
Role of interferon-gamma & its signaling pathways in IL-12-induced immunedisease of the CNS
Determining the activity and interactions of messenger chemicals that facilitate the immune attack in MS and may be suitable therapeutic targets.
Project Number: RG 3050-B-2
Funding: $298,066
Term: 10/1/02 to 9/30/05
Category: Human Genetics
Characterization of genetic loci predisposing to multiple sclerosis
Searching for genetic abnormalities that may contribute to making persons susceptible to developing MS.
Project Number: RG 3567-A-1
Funding: $419,918
Term: 4/1/04 to 3/31/07
Category: Neurophysiology
Formation and maintenance of paranodal axoglial junctions in myelinatednerve
Molecular interactions between nerve fibers and myelin which are crucial to the health of both and which may be future targets for MS therapy.
Project Number: PP0928
Funding: $44,000
Term: 6/1/03 to 5/31/04
Category: Immunology
Is microchimerism associated with multiple sclerosis?
Determining if the sharing of cells between mothers and offspring is associated with MS.
Project Number: RG 2643C8/T
Funding: $427,185
Term: 10/1/02 to 9/30/05
Category: Immunology
The role of driver clones in autoimmunity
Studying a type of immune cell that may drive MS, and attempting to protect mice with an MS-like disease from these cells.
Project Number: JF 2107-A-1
Funding: $512,867
Term: 7/1/01 to 6/30/06
Category: Measuring MS Disease Activity
The onset of progressive MS: structural and functional determinants
Using brain imaging as a way to observe the process by which relapsing-remitting MS becomes progressive disease.
Project Number: RG 3516-A-8
Funding: $579,374
Term: 4/1/04 to 3/31/07
Category: Immunology
Targeting allergy pathways in MS/EAE
Exploring whether and how antihistamine drugs inhibit MS-like disease and the implications for treating multiple sclerosis.
Project Number: RG 3344-A-1
Funding: $308,844
Term: 4/1/02 to 3/31/05
Category: Biology of Glia
Genetic mechanisms of myelination
Searching for the genes that control the development and repair of the myelin that insulates nerve fibers and which is targeted in MS.
Project Number: RG 3355-A-1
Funding: $351,496
Term: 4/1/02 to 3/31/05
Category: Biology of Glia
Role of a potassium channel, Kv3.1, and its interaction with a myelin membraneprotein
Exploring the role of a tiny pore on the surface of myelin-making cells, called a potassium channel, in the development of nerve-insulating myelin.
Project Number: RG 829-N-38
Funding: $633,900
Term: 9/30/01 to 9/30/04
Category: Tissue/DNA Banks
Human Brain and Spinal Fluid Resource Center
Developing and maintaining a tissue bank of tissue specimens from people with MS for use in research.
Project Number: PP0941
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: Immunology
Extracellular superoxide dismutase in the regulation of immune responses inEAE
Determining the role of a molecule that may be able to inhibit the immune attack in an MS-like disease.
Project Number: RG 3222A8/2
Funding: $479,780
Term: 9/30/01 to 9/30/04
Category: Immunology
Regulation of immune responses by nitric oxide
Examining the role of a molecule that may prove to be an important regulator of the immune attack in MS.
Project Number: RD 3407-A-8
Funding: $495,000
Term: 8/1/02 to 7/31/06
Category: Immunology
Mechanisms underlying the protective effect of pregnancy doses of estrogens inEAE
Studying the effects of the sex hormone estrogen on immune-system responses in mice with MS-like disease for clues to its potential use to treat human MS.
Project Number: RG 3239A7/2
Funding: $675,616
Term: 4/1/02 to 3/31/05
Category: Therapy/Management of MS
Testosterone treatment for multiple sclerosis: a preliminary trial
Testing whether the male sex hormone, testosterone, is safe and can produce positive immunesystem and disease changes in men who have MS.
Project Number: RG 3021A1/1
Funding: $1,313,891
Term: 4/1/99 to 9/30/04
Category: Therapy/Management of MS
T cell vaccine: a clinical trial for progressive MS
Testing an experimental treatment in people with progressive MS that specifically kills immune cells that recognize and launch attacks against myelin.
Funded in part by a gift from Brenda Earl and Mike De Paola through the NMSS New York City Chapter
Project Number: PP0946
Funding: $44,000
Term: 8/1/03 to 7/31/04
Category: Immunology
Design of a small molecule blocker as a therapeutic for multiple sclerosis
Developing compounds that may prove effective in treating MS.
Paid in full by funds raised by the QVC Cure by the Shore in collaboration with the NMSS Southern California Chapter
Project Number: FG 1535-A-1
Funding: $130,947
Term: 8/1/03 to 7/31/06
Category: Immunology
The involvement of self-reactive T cells in autoimmune neurological disease
Studying a rodent model of myelin damage for clues to how an immune attack may cause this damage in MS.
Project Number: FA 1549-A-1
Funding: $148,265
Term: 8/1/03 to 7/31/06
Category: Immunology
Mechanisms for immune modulation by statin treatment of CNS autoimmunedisease
Examining mechanisms responsible for the ability of cholesterol-lowering statin drugs to modulate the immune attack in MS-like disease in mice.
Project Number: RG 3206B4/1
Funding: $461,291
Term: 10/1/03 to 9/30/06
Category: Immunology
MHC class II regulation and antigen presentation in CNS autoimmunity
Evaluating the role of an immune-modulating molecule that may contribute to inflammation in MS and susceptibility to the disease.
Project Number: RG 2859C8/T
Funding: $180,640
Term: 1/1/03 to 9/30/04
Category: Tissue/DNA Banks
Rocky Mountain Multiple Sclerosis Center Tissue Bank
Collecting and maintaining a bank of human MS tissue specimens as a resource for scientists studying MS.
Project Number: PP0961
Funding: $44,000
Term: 11/1/03 to 10/31/04
Category: CNS Repair
Lipoprotein lipase and nerve myelination
Exploring a possible role for an enzyme in myelin repair in an MS-like disease in mice.
Project Number: RG 3448-A-1
Funding: $489,146
Term: 4/1/03 to 3/31/06
Category: Neurophysiology
Selective targeting of sodium channel isoforms in neurons
Identifying mechanisms by which myelin-making cells may help to maintain healthy nerve impulse conduction.
Project Number: RG 3307-A-1
Funding: $319,972
Term: 9/30/01 to 9/30/04
Category: Neuropathology
Neuronal tract degeneration in the earliest stages of multiple sclerosis
Exploring damage to nerve fibers that may occur in people in the earliest stages of MS using advanced brain imaging techniques.
Project Number: PP0971
Funding: $44,000
Term: 2/1/04 to 1/31/05
Category: Rehabilitation
Enhancing verbal memory in MS with music: an EEG study
Testing the effectiveness of a musical technique to improve memory in people with MS.
Project Number: PP0959
Funding: $44,000
Term: 2/1/04 to 1/31/05
Category: Immunology
Identification of MS antigens with recombinant antibodies cloned from MS CSFB cells
Developing a method of identifying the agent or agents that trigger the immune attack in MS.
Project Number: RG 2843B3/1
Funding: $343,451
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Localization of mRNAs in oligodendrocytes
Studying the genetic signals that control growth of proteins in nerve-insulating myelin, to find ways of stimulating myelin repair.
Funded in part by a gift from the NMSS Ohio Valley Chapter
Project Number: PP0963
Funding: $44,000
Term: 1/1/04 to 12/31/04
Category: Biology of Glia
Ion channels and GABA receptors in glial progenitors of the subventricularzone
Studying cells that represent a potential resource for repairing myelin damage in MS.
Project Number: CA 1009A10/1
Funding: $825,000
Term: 4/1/04 to 3/31/09
Category: CNS Repair
Collaborative MS Research Center Award
Exploring tissue damage in MS and testing ways to protect and repair central nervous system tissue.
Project Number: RG 2135-E-9
Funding: $566,416
Term: 10/1/02 to 9/30/06
Category: CNS Repair
Systemic delivery of bone marrow cells to repair demyelinated spinal cord
Attempting to restore nerve-insulating myelin in the spinal cords of mice by injecting cells from bone marrow, and testing for signs of recovery.
Funded in part by a Research Honor Roll donation by the NMSS Western Connecticut Chapter
Project Number: FG 1423A1/1
Funding: $142,771
Term: 8/1/02 to 7/31/05
Category: Biology of Glia
MOG signaling in oligodendrocytes via lipid rafts
Examining how a protein component of nerve-insulating myelin functions for insights into how it might become a target for immune attack in MS.
Project Number: RG 2826B4/1
Funding: $454,823
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
The role of NG2+ glial progenitor cells in remyelination
Exploring immature brain cells that may be capable of maturing into adult myelin-making cells, and their role in myelin repair in MS.
Project Number: RG 2394-D-5
Funding: $561,226
Term: 10/1/02 to 9/30/06
Category: Immunology
Central nervous system inflammation & antigen presentation in MOG-inducedEAE
Understanding immune-system activity in the brain and spinal cord during the development of MS-like disease.
Project Number: RG 1912D8/1
Funding: $519,249
Term: 4/1/00 to 3/31/05
Category: Neurophysiology
Molecular pathophysiology of axons in demyelinating diseases
Understanding mechanisms of nerve fiber destruction in MS, for clues to preventing it.
Paid in part by the Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research through the NMSS New York City Chapter, in honor of Susan Thomases
Project Number: RG 3083B3/1
Funding: $354,635
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Development of oligodendrocyte & microglia in the human brain: relevance forMS
The role of specific brain cells in the development of myelin-making cells and how they impact growth and repair of nerve-insulating myelin.
Project Number: PP0960
Funding: $44,000
Term: 12/1/03 to 11/30/04
Category: Psychosocial Aspects of MS
Prospective memory and the effect of a mnenomic strategy in multiple sclerosis
Exploring a type of memory in people with MS, and evaluating a strategy for improving this aspect of memory.
Project Number: RG 3294-A-12
Funding: $438,976
Term: 9/30/01 to 9/30/04
Category: Immunology
Development of small organic molecules that bind to HLA
Designing small molecules that may be able to block the immune attack against myelin in MS.
Project Number: RG 3406-A-2
Funding: $342,021
Term: 4/1/03 to 3/31/06
Category: Immunology
Regulation and structural study of a novel protease implicated indemyelination
Studying an enzyme in the nervous system that may play an important role in myelin loss in MS.
Project Number: PP0943
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: CNS Repair
Evaluation of secretase inhibitors as therapeutic agents for multiple sclerosis
Determining the effectiveness of a compound in stimulating myelin repair.
Project Number: PP0917
Funding: $44,000
Term: 5/1/03 to 4/30/04
Category: Rehabilitation
Resistance training effects on muscle function in multiple sclerosis
Evaluating the effects of an exercise program on improving muscle function in people with MS.
Project Number: RG 3296-A-1
Funding: $400,016
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Controlling myelin basic protein expression and CNS myelination by the QKIprotein
Investigating a specific protein to understand its function in myelin formation and its potential role in myelin repair.
Project Number: PP0882
Funding: $33,000
Term: 9/1/02 to 8/31/04
Category: Human Genetics
African Americans with multiple sclerosis and apoE 4 genotyping
Determining the role of a specific gene in the susceptibility of African Americans to MS.
Project Number: FG 1563-A-1
Funding: $120,382
Term: 9/1/03 to 8/31/06
Category: Immunology
Role of dendritic cells in the initiation and progression of central nervous systemautoimmune disease
Determining whether cells that usually stimulate the immune attack can, in fact, neutralize this attack in an MS-like disease in mice.
Project Number: RG 3266A2/1
Funding: $387,713
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Role of ceramide in oligodendrocyte cell death
Investigating a molecule that may contribute to the death of myelin-making cells in MS and testing compounds that may inhibit it.
Project Number: FG 1515A1/1
Funding: $141,771
Term: 8/1/03 to 7/31/06
Category: Biology of Glia
Noradrenergic regulation of microglial activation
Analyzing complex mechanisms by which certain brain cells are activated to participate in the immune attack in an MS-like disease in rats.
Project Number: FG 1442-A-1
Funding: $119,725
Term: 9/1/01 to 8/31/04
Category: Immunology
Role of monocyte chemotactic protein-1, MCP-1, in autoimmuneencephalomyelitis
Investigating the role of certain immune molecules in decreasing the severity of MS-like disease.
Project Number: RG 3545-A-7
Funding: $360,113
Term: 4/1/04 to 3/31/07
Category: Immunology
Therapeutic potential of PPAR delta agonists in demyelinating disease
Determining whether a natural brain chemical can stop MS-like disease and stimulate myelin repair by replacement cells.
Project Number: HC 0049
Funding: $379,390
Term: 7/1/02 to 6/30/05
Category: Health Care Delivery/Policy
Aging with multiple sclerosis: unmet needs in the Great Lakes region
Exploring the impact of aging on persons with MS, and identifying their health and quality of life needs.
Project Number: PP0918
Funding: $44,000
Term: 3/1/03 to 2/28/05
Category: Biology of Glia
Myelin formation in neural-glial co-cultures
Identifying factors that may be essential for the formation of nerve-insulating myelin.
Project Number: RG 3546-A-1
Funding: $593,965
Term: 4/1/04 to 3/31/08
Category: Immunology
Understanding the role of gamma/delta T cells in relapsing EAE
The potential of specific immune cells for turning off the immune attack in MS-like disease, and their promise for treating human MS.
Project Number: RG 3392A5/2
Funding: $359,241
Term: 10/1/03 to 9/30/06
Category: Immunology
Pathogenic mechanisms of TMEV-induced demyelination
How a mouse virus causes destruction of nerve-insulating myelin, as a possible model for how MS is triggered.
Project Number: FG 1516-A-1
Funding: $130,947
Term: 9/1/02 to 8/31/05
Category: Immunology
Protective mechanisms of CD30IgG3 in relapsing experimental EAE
Studying how an experimental therapy may stop the immune attack in mice with MS-like disease, to explore its possible usefulness in treating MS.
Project Number: RG 3054B2/1
Funding: $605,387
Term: 10/1/03 to 9/30/07
Category: Neuropharmacology
Thromboxane A2 modulation of oligodendrocyte development and myelinsynthesis
Exploring a natural molecule that may be involved in stimulating the growth and repair of nerve-insulating myelin.
Funded in part through a gift from the Dan Family through the NMSS Greater Illinois Chapter
Project Number: RG 3489-A-6
Funding: $552,526
Term: 10/1/03 to 9/30/07
Category: Immunology
Cellular and molecular mechanisms of CD4+CD25+ regulatory T cells in EAE
Investigating a possible protective role for regulatory immune cells during the onset and progression of an MS-like disease.
Project Number: RG 3289-A-5
Funding: $111,111
Term: 9/30/01 to 9/30/04
Category: Immunology
Mechanisms of therapeutic blockade of CD154 in prevention of relapsing EAE
Exploring ways to block the interaction of immune cells to stop ongoing immune attacks in MS-like disease, and ultimately in MS.
Project Number: FA 1517-A-1
Funding: $154,745
Term: 9/1/02 to 8/31/05
Category: Immunology
The role of innate immune responses in a virus-induced model of multiplesclerosis
Studying the effect that the immune response to viruses and bacteria has on the development of an MS-like disease in mice. 21
Project Number: RG 3291A4/T
Funding: $462,527
Term: 4/1/02 to 9/30/04
Category: Biology of Glia
Global gene expression analysis of developing & perturbed oligodendrocytes
Identifying genes that may be important to the growth and development of myelinmaking cells.
Project Number: RG 3456-A-10
Funding: $284,433
Term: 10/1/03 to 9/30/06
Category: Infectious Agents
Theiler's virus-induced demyelinating disease
Clarifying the mechanisms through which a virus triggers MR-like disease in mice, as a model for what might occur in MS.
Project Number: FG 1572-A-1
Funding: $130,947
Term: 8/1/03 to 7/31/06
Category: Biology of Glia
Development of a mouse model for the inducible ablation of oligodendrocytes
Understanding factors that promote or inhibit the repair of nerve-insulating myelin and nerve tissue, and how they might be utilized to stimulate repair in MS.
Project Number: RG 2638-C-3
Funding: $393,041
Term: 4/1/02 to 3/31/05
Category: Biology of Glia
Study of myelin/oligodendrocyte glycoprotein - human splice variants
Exploring the functions of a protein component of nerve-insulating myelin, which may be an immune-system target in MS.
Project Number: RG 2864-C-4
Funding: $393,971
Term: 4/1/04 to 3/31/07
Category: Infectious Agents
Pathogenesis of MHV-induced demyelination in RAG1-/- mice
Determining immune mechanisms involved in myelin destruction in a viral-induced model of MS, in search improved therapies for MS.
Project Number: RG 3188A3/1
Funding: $378,206
Term: 4/1/01 to 3/31/05
Category: Biochemistry/Biophysics
Protective mechanisms in CNS demyelinating diseases
Understanding natural defense mechanisms of cells that may be exploited to limit tissue damage in MS.
Project Number: PP0884
Funding: $33,000
Term: 9/1/02 to 8/31/04
Category: Immunology
Evaluation of methotrexate-peptide conjugate in an animal model of MS
Developing a novel method of delivering immune therapy to treat MS-like disease in mice.
Project Number: PP0970
Funding: $44,000
Term: 1/1/04 to 12/31/04
Category: Immunology
Characterization of tolerogenic antigen-presenting cells for use in the treatmentof EAE
Determining the effectiveness of a type of cell for treating an MS-like disease in mice.
Project Number: RD 3410-A-1
Funding: $247,500
Term: 7/1/02 to 6/30/05
Category: Immunology
Sex-based differences in regulatory T cell responses
Exploring whether sex hormones alter the activity of regulatory cells that can naturally dampen destructive immune responses.
Project Number: RG 3275-A-1
Funding: $341,043
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Lineage analyses and transcription control of oligodendrocyte genesis
Understanding the origins of myelin-making cells, and what factors are involved in their growth and development.
Project Number: RG 3413A4/1
Funding: $323,139
Term: 10/1/03 to 9/30/06
Category: Immunology
Progression of autoimmune encephalomyelitis
Examining a subset of immune cells that seem to contribute to a severe, progressive course of MS-like disease in mice.
Project Number: RG 3374-A-1
Funding: $373,804
Term: 10/1/02 to 9/30/05
Category: Biochemistry/Biophysics
Role of fatty acid binding proteins in the pathogenesis of EAE
How a molecule that allows fatty acids to function may play a role in the immune attack in MS and MSlike disease and how it might be blocked.
Project Number: PP0922
Funding: $44,000
Term: 6/1/03 to 5/31/04
Category: CNS Repair
MR tracking of magnetically labeled stem cells in a mouse EAE model
Testing a novel method of tracing the fate of stem cells introduced into mice with MS-like disease, to determine whether they reach sites needing tissue repair.
Funded in full by donors to the National MS Society's Maryland Chapter
Project Number: CA 1029-A-2
Funding: $825,000
Term: 4/1/04 to 3/31/09
Category: Neuropathology
Collaborative MS Research Center Award
An interdisciplinary effort to define how nerve fibers are damaged in MS and to search for ways to protect them.
Project Number: PP0937
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: Psychosocial Aspects of MS
FMRI investigation of the neural basis of cognitive fatigue in MS
Studying cognitive fatigue in people with MS using a novel imaging technique.
Project Number: RG 2747-C-3
Funding: $707,740
Term: 9/30/01 to 9/30/06
Category: Immunology
Structural basis of molecular mimicry in multiple sclerosis
Determining the three-dimensional structure of molecules involved in the immune attack against nervous-system tissue in MS.
Project Number: PP0932
Funding: $44,000
Term: 7/1/03 to 6/30/04
Category: Measuring MS Disease Activity
Polyol metabolism and disease progression in multiple sclerosis
Taking a new approach to understanding the mechanism of nerve fiber damage in progressive MS.
Project Number: RG 3277A1/1
Funding: $82,500
Term: 10/1/02 to 9/30/05
Category: Immunology
Gene therapy for tolerance induction in EAE as a model for MS
Infecting immune cells with viruses genetically engineered to deliver myelin proteins, in an attempt to halt the immune attack in MS-like disease.
Project Number: HC 0060
Funding: $296,897
Term: 7/1/03 to 6/30/05
Category: Health Care Delivery/Policy
Understanding the health care experiences of minority populations with MS
Conducting a survey to determine whether the health care experiences of African Americans and Hispanics with MS are different from that of Caucasians with MS.
Project Number: FA 1485-A-2
Funding: $149,265
Term: 8/1/02 to 7/31/05
Category: Immunology
Gene therapy for tolerance to encephalitogenic proteins
Testing the effectiveness of gene therapy -- a novel therapeutic approach -- in an MS-like disease in mice.
Project Number: RG 3310A3/1TT
Funding: $219,847
Term: 7/1/03 to 3/31/05
Category: Immunology
EAE: T cell phenotype determines site and mechanism of disease
Understanding why certain immune cells attack particular areas of the brain and spinal cord in MS-like disease, and how they cause different symptoms.
Project Number: FG 1522-A-1
Funding: $130,947
Term: 8/1/03 to 8/31/06
Category: Biology of Glia
Regulation of Olig2 in oligodendrocyte fate determination
Identifying proteins that promote the formation of myelin-making cells, for clues to stimulating myelin repair in MS.
Project Number: PP0925
Funding: $44,000
Term: 6/1/03 to 5/31/04
Category: Epidemiology
Prospective study of vitamin D and multiple sclerosis
Investigating whether higher blood levels of vitamin D reduces the risk of developing MS in a population study.
Paid in full by funds raised by the QVC Cure by the Shore in collaboration with the NMSS Southern California Chapter
Project Number: FG 1566-A-1
Funding: $162,160
Term: 8/1/03 to 7/31/06
Category: Immunology
Chemokine receptor expression and immune regulation in multiple sclerosis
Investigating the role of immune messenger proteins and the molecules with which they interact in the development of multiple sclerosis.
Project Number: FA 1579-A-1
Funding: $154,745
Term: 8/1/03 to 7/31/06
Category: Immunology
Antigen specificity of CD8 T cells in multiple sclerosis plaques
Examining the specific targets on nerve-insulating myelin which immune cells react against in areas of myelin damage in people with MS.
Project Number: FG 1453-A-1
Funding: $120,725
Term: 7/1/01 to 6/30/04
Category: Immunology
Immunoregulatory role of a suppressive costimulatory molecule, PD-1, in MS
Determining whether a molecule that can normally suppress certain immune attacks is abnormal in people with MS.
Project Number: FG 1511-A-1
Funding: $130,947
Term: 9/1/02 to 8/31/05
Category: Biology of Glia
The role of integrins in myelination
Studying molecular signals that influence the production of nerve-insulating myelin, for clues to ways to stimulate myelin repair in MS.
Project Number: FG 1478-A-1
Funding: $120,382
Term: 8/1/02 to 7/31/05
Category: Immunology
Effect of polymorphic forms of a Th1-specific molecule, TIM-3, on EAE
Exploring a molecule on aggressive immune cells which may be a potential target for developing therapies to stop the immune attack in MS.
Project Number: FP 1532-A-1
Funding: $11,710
Term: 8/1/03 to 7/31/05
Category: Therapy/Management of MS
Sylvia Lawry Physician Fellowship
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: RG 2989B3/1
Funding: $390,691
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Mechanisms of chemokine-mediated astrocyte activation
Investigating how immune messenger chemicals interact with specific brain cells during the immune attack in MS.
Project Number: FP 1506-A-1
Funding: $120,000
Term: 8/1/02 to 7/31/05
Category: Therapy/Management of MS
Sylvia Lawry Physician Fellowship
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: CA 1001-A-14
Funding: $825,000
Term: 4/1/03 to 3/31/08
Category: Human Genetics
Palmer Collaborative MS Research Center Award: MS Targeted HaplotypeProject
A multi-disciplinary effort to take the next big step to finding MS genes and correlate them with clinical findings, to find the cause of MS.
Funded in full by a gift from Barbara Palmer to the NMSS Central New England Chapter
Project Number: RG 3308A10/1
Funding: $370,865
Term: 4/1/02 to 3/31/05
Category: Immunology
Regulatory T cells in multiple sclerosis
Examining immune cells that appear to be crucial to stopping immune attacks against the body's own tissues, and their possible failure in MS.
Project Number: RG 3417A12/2
Funding: $670,788
Term: 4/1/04 to 3/31/07
Category: Human Genetics
A whole genome admixture scan for the multiple sclerosis genes
Scanning for MS genes in genetic material from patients whose ancestry contain a mix of populations at high risk and at low risk for MS.
Project Number: RG 3236A1/1
Funding: $325,358
Term: 9/30/01 to 9/30/04
Category: Epidemiology
Risk factors and incidence of MS in a population-based follow-up study
Asking whether studying medical data on a large group of people over time can reveal possible risk factors contributing to the development of MS.
Project Number: RG 3504-A-8
Funding: $237,916
Term: 10/1/03 to 9/30/07
Category: Immunology
Role of PD1-PDL pathway in EAE
Understanding the interaction of molecules on immune cells which may help stimulate recovery from an MS-like disease in mice.
Project Number: RG 2988B6/2
Funding: $521,492
Term: 4/1/02 to 3/31/05
Category: Immunology
Mechanisms of immune regulation in chronic EAE
Investigating the presence and function of specific immune cells that may be responsible for preventing or stopping the immune attack in MS-like disease.
Project Number: FG 1575-A-1
Funding: $121,982
Term: 8/1/03 to 7/31/06
Category: Immunology
Role of costimulation in CD25+CD4+ regulatory T cell function in EAE
Developing a mouse model to study the role of specific immune cells in regulating the immune attack in MS-like disease.
Project Number: RG 2571-D-9
Funding: $414,048
Term: 4/1/03 to 3/31/06
Category: Immunology
Pathogenic & regulatory mechanisms in EAE
Identifying factors that control immune T cells that recognize and can attack myelin in MS-like disease.
Project Number: PP0955
Funding: $44,000
Term: 9/30/03 to 9/30/04
Category: Infectious Agents
Pathogen discovery by computational subtraction in multiple sclerosis
Investigating a possible role for infectious agents in MS using novel technology.
Project Number: HC 0032
Funding: $3,287,078
Term: 4/1/99 to 12/31/06
Category: Health Care Delivery/Policy
The Sonya Slifka longitudinal multiple sclerosis study
Establishing a researchoriented repository of in-depth information about a nationwide group of people with MS over time.
The Sonya Slifka longitudinal multiple sclerosis study
Project Number: HC 0053
Funding: $493,059
Term: 7/1/02 to 6/30/05
Category: Health Care Delivery/Policy
Quality of health care in multiple sclerosis
Analyzing standard and recommended health care practices in persons with MS to establish a basis for improving standards of care.
Project Number: FA 1449-A-1
Funding: $129,566
Term: 7/1/01 to 6/30/04
Category: Immunology
Analysis of endogenous myelin proteolipid protein-reactive T cell repertoire
Exploring aspects of immune responses that might account for why the immune system attacks the body's own tissues in people with MS.
Project Number: HC 0059
Funding: $485,899
Term: 7/1/03 to 6/30/06
Category: Health Care Delivery/Policy
Quality of mental health care in multiple sclerosis
Identifying aspects of mental health care and treatment in MS to maximize its quality and usefulness.
Project Number: JF 2100-A-1
Funding: $530,452
Term: 7/1/00 to 6/30/05
Category: Biology of Glia
Oligodendrocyte lineage gene function in the central nervous system
Studying genes that determine the development and function of myelin-making cells.
Funded in part by a gift from Joan and Virgil Stiefel Simon through the NMSS Colorado Chapter
Project Number: RG 2779-C-4
Funding: $431,024
Term: 4/1/03 to 3/31/07
Category: Immunology
Manipulation of the B7-CD28/CTLA-4 costimulatory pathway & EAE
Attempting to block immune activity in MS-like disease in search of better treatment for human MS.
Funded in part by the Estate of Norman Cohn
Project Number: CA 1022-A-1
Funding: $825,000
Term: 4/1/03 to 3/31/08
Category: CNS Repair
Collaborative MS Research Center Award
Joining forces to develop strategies for tissue repair and identify new therapeutic targets in MS.
Funded in full by the NMSS New York City Chapter
Project Number: FA 1433A1/T
Funding: $74,034
Term: 10/1/02 to 6/30/04
Category: Biology of Glia
Interactions of oligodendrocyte precursors and neurons in the PDFR alphamutant brain
Examining the role of a specific protein in the formation of myelinmaking cells, for clues to stimulating myelin repair in MS.
Project Number: PP0934
Funding: $44,000
Term: 7/1/03 to 6/30/04
Category: Rehabilitation
Postural stability and fatigue in multiple sclerosis
Determining the factors that contribute to balance control problems in people with MS.
Project Number: RG 3426A2/1
Funding: $473,801
Term: 10/1/03 to 9/30/06
Category: Immunology
The function of toll-like receptors & innate immunity in oligodendrocyte injury
Determining how the interaction between infectious agents and the immune system may contribute to myelin and nerve fiber damage in MS.
Project Number: FG 1479A1/1
Funding: $141,771
Term: 8/1/03 to 7/31/06
Category: Immunology
Regulatory effect of lymphocyte-driven TGF in autoimmune encephalomyelitis
Understanding the role of an immune messenger protein that may regulate MS-like disease in mice, for clues to better treatments for MS.
Project Number: FG 1569-A-1
Funding: $120,382
Term: 8/1/03 to 7/31/06
Category: Immunology
The role of CD8+ T regulatory cells in EAE
Defining the mechanisms by which a subset of immune cells may regulate the immune attack in MS-like disease in mice.
Project Number: RG 3204A1/1
Funding: $433,728
Term: 9/30/01 to 9/30/04
Category: Neuropathology
Models of axonal injury due to myelin disorders
Exploring the pathology that underlies the release of a brain chemical which is currently used to measure nerve cell damage in MS.
Project Number: RG 2891-C-4
Funding: $480,213
Term: 10/1/03 to 9/30/06
Category: Biology of Glia
Molecular mechanisms of stress induced oligodendrocyte cell death
Clarifying factors that may contribute to the death of cells that make nerve-insulating myelin, to develop strategies to offset this damage in MS.
Project Number: RG 2882C4/1
Funding: $566,257
Term: 4/1/04 to 3/31/07
Category: Neurophysiology
Molecular control of sodium channel density and localization in myelinatedaxons
Investigating how protein pores in nerve fibers become properly clustered to allow for normal nerve signal conduction.
Project Number: RG 2882-B-3
Funding: $546,784
Term: 9/30/00 to 9/30/04
Category: Neurophysiology
Molecular control of sodium channel density and localization in myelinatedaxons
Understanding how protein pores in nerve fibers are regulated to allow for proper nerve signal conduction.
Project Number: RG 2769-C-6
Funding: $413,477
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
The role of homeodomain protein, Gtx, in oligodendrocyte differentiation
Investigating the role of a newly identified protein in the formation of myelin, the nerve-fiber coating destroyed by MS.
Project Number: RG 3410-A-2
Funding: $385,367
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Axoglial communication through regulated release of neuregulin
Understanding the communication and mutual support between nerve fibers and myelin-making cells that maintain the function and structure of both.
Project Number: RD 3409A1/T
Funding: $491,246
Term: 1/1/03 to 6/30/06
Category: Immunology
Mechanisms regulating neutrophil activation in pregnancy
Tracking specific immune cells during pregnancy, to improve understanding of factors that may be capable of turning off inflammation such as that involved in MS.
Project Number: RG 3449-A-6
Funding: $469,087
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Mammalian oligodendrocytes are sexually dimorphic
Examining biologic differences in myelin-making cells between male and female mice with an MS-like disease, and implications for human MS.
Project Number: PP0958
Funding: $44,000
Term: 11/1/03 to 10/31/04
Category: Immunology
Molecular mechanisms of oligodendrocyte damage by MOG specific T cells
Determining the immune mechanisms of action in two types of MS-like disease in mice.
Project Number: PP0926
Funding: $44,000
Term: 1/1/04 to 12/31/04
Category: Immunology
Low cell-dose transfer of suppression in EAE
Investigating a novel method of treating an MS-like disease in mice.
Project Number: RG 1073H11/1
Funding: $283,840
Term: 9/30/99 to 9/30/04
Category: Immunology
Regulation of autoimmune encephalomyelitis
How the activation of myelindestructive immune cells is controlled in MS-like disease.
Project Number: RG 3288A6/1
Funding: $405,623
Term: 4/1/02 to 3/31/05
Category: Immunology
CD1-restricted regulation of murine adoptive EAE
Attempting to prove that a specific type of immune cell plays a crucial role in the onset of MS-like disease in mice, and by implication, in human MS.
Project Number: FA 1503-A-1
Funding: $101,653
Term: 8/1/02 to 7/31/04
Category: Biology of Glia
Oxidative-stress induced death pathways in oligodendrocytes
Studying biological mechanisms that may lead to the death of myelin-making cells in MS.
Project Number: RG 3481-A-1
Funding: $280,273
Term: 10/1/03 to 9/30/05
Category: CNS Repair
Genetic analysis of spontaneous remyelination
Studying mechanisms that lead to spontaneous myelin repair and restoration of neurologic function in a rodent model of MS-like disease.
Funded in part through a gift from the Dan Family through the NMSS Greater Illinois Chapter
Project Number: FA 1578-A-1
Funding: $161,560
Term: 8/1/03 to 7/31/06
Category: Immunology
Disease pathogenesis of MOG-induced EAE in HLA class II transgenic mice
Understanding the role of genes that control immune responses in the development of MS, to find ways to stop the immune attack.
Project Number: RG 3185-A-2
Funding: $1,851,117
Term: 4/1/00 to 3/31/05
Category: Neuropathology
Clinico-pathological correlates of the MS lesion
Studying MS lesions (damaged areas) in individuals with MS for clues to different patterns of destructive immune factors and correlating findings with clinical manifestations.
Project Number: RG 3255A1/1
Funding: $268,048
Term: 9/30/01 to 9/30/04
Category: Rehabilitation
Effects of an energy conservation course for persons with multiple sclerosis
Can strategies to save energy and ward off fatigue improve quality of life in MS?
Project Number: CA 1011A8/1
Funding: $825,000
Term: 4/1/04 to 3/31/09
Category: CNS Repair
Collaborative MS Research Center Award
Screening small molecules for their potential to help define functions of myelin-making cells, and their potential to stimulate myelin repair in MS.
Project Number: PP0964
Funding: $44,000
Term: 12/1/03 to 11/30/04
Category: Neuropathology
Kallikrein 6 mRNA splice variants as targets to treat CNS demyelinatingdisease
Investigating possible targets for therapies that treat inflammation and tissue damage in an MS-like disease in mice.
Project Number: RG 3367-A-2
Funding: $395,838
Term: 10/1/02 to 9/30/05
Category: Neuropathology
Mechanisms of myelencephalon specific protease-mediated proteolysis indemyelination
The role of a protein-destroying enzyme in the destruction of nerveinsulating myelin in MS-like disease, and possible ways to block its activity.
Project Number: RD 3406-A-6
Funding: $749,820
Term: 9/1/02 to 8/31/05
Category: Human Genetics
Interferon gamma polymorphisms and gender bias in MS
Studying genetic variations related to an interferon and their possible connection to gender differences in susceptiblity to MS.
Funded in part by a gift from the Thomas Maren Foundation
Project Number: CA 1012-A-13
Funding: $825,000
Term: 4/1/03 to 3/31/08
Category: Measuring MS Disease Activity
Collaborative MS Research Center Award
A major effort to apply new magnetic resonance technology to tracking brain tissue damage and recovery in MS.
Project Number: RG 3292A9/1
Funding: $627,832
Term: 4/1/02 to 3/31/05
Category: Therapy/Management of MS
A phase II trial of Rituxan in multiple sclerosis
A clinical trial of an immunebased therapy for treatment of relapsing-remitting MS.
Project Number: RG 3085A8/1T
Funding: $100,471
Term: 10/1/01 to 9/30/04
Category: Therapy/Management of MS
Precipitation of MS exacerbations by urinary tract infections
Determining whether urinary tract infections trigger flare-ups of MS, and the impact of preventing such infections.
Funded in part by a gift from the NMSS Ohio Valley Chapter
Project Number: RG 3450A1/2
Funding: $523,529
Term: 4/1/04 to 3/31/07
Category: Immunology
Chemokines & lymphocyte trafficking in the pathogenesis of experimentalautoimmune encephalomyelitis
Exploring chemical factors that attract destructive immune forces into the brain in MS-like disease, for clues to stopping their entry to treat MS.
Project Number: RG 3314-A-3
Funding: $248,076
Term: 9/30/01 to 9/30/04
Category: Immunology
Tumor necrosis factor receptor family molecules and EAE pathogenesis
Examining immune molecules in MS-like disease that may be involved in the death of myelin-making cells in MS.
Project Number: RG 3376A2/1
Funding: $496,973
Term: 4/1/03 to 3/31/06
Category: Neuropathology
In vivo characterization of white matter injury in the central nervous system
Evaluating the potential of a novel imaging technology to diagnose and evaluate demyelinating disease.
Project Number: RG 3379A2/1
Funding: $489,489
Term: 4/1/03 to 3/31/06
Category: Immunology
Inhibiting demyelination by immunization using coxsackievirus vectors
Attempting to derail the immune attack in MS-like disease using a unique vaccination strategy.
Project Number: RG 3422A1/1
Funding: $273,946
Term: 10/1/03 to 9/30/06
Category: Immunology
Gemfibrozil & EAE
Testing the effectiveness of a cholesterol-lowering agent in suppressing disease activity and the immune attack in an MS-like disease in mice.
Project Number: RG 3381-A-2
Funding: $209,708
Term: 10/1/02 to 9/30/05
Category: Immunology
Role of IL-12 gene expression in virus-induced encephalomyelitis
Exploring the function of a gene that controls an immune-system messenger chemical and its possible activity in MS-like disease.
Project Number: FP 1443-A-1
Funding: $120,000
Term: 1/1/02 to 12/31/04
Category: Psychosocial Aspects of MS
Mood dysfunction in MS: immunologic correlation and immunotherapy
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: FG 1510-A-1
Funding: $93,344
Term: 8/1/02 to 7/31/04
Category: Psychosocial Aspects of MS
Functional and structural neuroimaging of executive functions in multiplesclerosis
Using advanced brain imaging to examine physiological processes during thinking and planning tasks to understand cognitive problems in MS.
Project Number: RG 3248-A-1
Funding: $279,454
Term: 4/1/01 to 3/31/05
Category: Measuring MS Disease Activity
Brain activation in MS: an fMRI study of working memory and motorfunctions
Using a novel brain imaging method to observe brain activity during memory and movement tasks in MS.
Project Number: RG 3421-A-4
Funding: $184,067
Term: 4/1/03 to 3/31/06
Category: CNS Repair
Understanding the molecular basis of remyelination failure
Identifying molecular mechanisms that may be responsible for incomplete myelin repair in MS.
Project Number: RG 3330A1/3
Funding: $428,372
Term: 4/1/04 to 3/31/07
Category: Rehabilitation
Working memory in MS: Using fMRI to identify the deficit
Correlating memory difficulties with brain activity to understand how to overcome such difficulties in MS.
Project Number: RG 2596B2/2
Funding: $285,154
Term: 9/30/00 to 9/30/04
Category: Psychosocial Aspects of MS
Relating cognitive dysfunction and functional status in multiple sclerosis
Assessing how cognitive problems experienced by people with MS affect their social, family and work lives.
Funded in part by a gift from the NMSS Gateway Area Chapter
Project Number: RG 3281A2/T
Funding: $359,002
Term: 10/1/03 to 9/30/05
Category: Immunology
Interferon-beta gene therapy in an animal model of MS
Testing a novel method of delivering interferon-beta into the brain in a mouse model of MS.
Project Number: RG 3503-A-2
Funding: $541,222
Term: 10/1/03 to 9/30/07
Category: Biology of Glia
Roles of neurofascin in nerve development and function
Studying the role of a protein in the formation of myelin and in the development of nerve fibers, to add data needed for stimulating tissue repair in MS.
Project Number: RG 3256A5/1
Funding: $297,902
Term: 9/30/01 to 9/30/04
Category: Biochemistry/Biophysics
N-acetylaspartate in myelin formation and demyelination
Determining the role of a brain chemical used by researchers to measure damage to nerve cells in MS.
Project Number: FA 1512-A-1
Funding: $166,226
Term: 8/1/02 to 7/31/05
Category: Biology of Glia
Regulation of myelin components by histone deacetylation
Understanding a mechanism that may enable the formation of nerve-insulating myelin, ultimately for clues to repairing myelin damaged in MS.
Project Number: RG 3402A3/1
Funding: $279,844
Term: 4/1/03 to 3/31/06
Category: Therapy/Management of MS
Effect of anti-interferon antibodies on interferon bioavailability in people withmultiple sclerosis
Determining whether immune antibodies impede the effectiveness of treating MS with interferon beta.
Project Number: RG 3353A1/1
Funding: $357,840
Term: 10/1/02 to 9/30/05
Category: Rehabilitation
Examining the demands of driving in multiple sclerosis
Understanding aspects of MS that may interfere with driving abilities, for clues to addressing this quality of life issue.
Project Number: RG 3301A1/1
Funding: $419,795
Term: 4/1/02 to 3/31/05
Category: Human Genetics
Identification of MS susceptibility genes on the 12p12 chromosome region
Homing in on genes on chromosomes that may help confer susceptibility to MS.
Project Number: PP0938
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: Biology of Glia
Myelin PLP-mediated transport of ions and small molecules across lipidmembranes
Examining the role of a major protein in nerve-insulating myelin.
Project Number: PP0950
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: Psychosocial Aspects of MS
Assessing attitudinal & structural barriers to physical & recreational activity
Determining factors that facilitate or discourage physical and recreational activity among people with MS who use wheelchairs and walkers.
Project Number: PP0845
Funding: $33,000
Term: 2/1/02 to 1/31/05
Category: Psychosocial Aspects of MS
Older individuals with multiple sclerosis: factors related to adjustment
Investigating the impact of aging on quality of life in individuals with MS.
Project Number: RG 2760C4/1
Funding: $601,392
Term: 4/1/03 to 3/31/07
Category: CNS Repair
Blocking the inhibition of axonal regeneration by MAG/myelin
Reversing the action of a protein that prohibits the regeneration of damaged nerve fibers, to find ways to re-grow nerve fibers that are lost in MS.
Funded in part by a gift from the Manhattan Society of NMSS New York City chapter
Project Number: RG 3479-A-2
Funding: $461,525
Term: 10/1/03 to 9/30/06
Category: Immunology
Initial activation of encephalomyelitogenic T cells in EAE
Studying whether inhibiting multiple immune messenger proteins can block their ability to help immune cells move into the brain and launch an attack in an MS-like disease model.
Funded in part by a gift from the NMSS New York City chapter
Project Number: RG 2898-B-2
Funding: $495,990
Term: 9/30/00 to (To Be Determined)
Category: CNS Repair
Therapeutic remyelination using human neural and white matter progenitorcells
Attempting to repair myelin damage by transplanting new myelin-making cells in MS-like disease.
Funded in full by gifts from the Barancik Foundation and the Alan Buegeleisen Research Fund
Project Number: FA 1547-A-1
Funding: $105,318
Term: 8/1/03 to 9/30/05
Category: Diagnostic Methods
Novel MR spectroscopic markers of primary progressive multiple sclerosisactivity
Using novel technology to determine whether tracking levels of certain brain chemicals can help to monitor disease activity in people with primary-progressive MS.
Funded by the NMSS New York City Chapter through the Martin S. Davis Research Fellowship Endowment
Project Number: RG 3521-A-6
Funding: $632,251
Term: 4/1/04 to 3/31/06
Category: Human Genetics
Variants of beta-chemokines within chromosome 17q11 in MS
Searching for possible gene variations in a specific chromosome region that may account for increased susceptibility to MS.
Project Number: RG 3334A4/T
Funding: $405,594
Term: 10/1/02 to 9/30/05
Category: Human Genetics
Nuclear and mitochondrial candidate genes in MS
Identifying genes that contribute to susceptibility to disability in people with MS.
Funded in part through a gift from the Manhattan Society of the NMSS New York City Chapter
Project Number: RG 3315A4/1
Funding: $784,201
Term: 4/1/02 to 3/31/07
Category: Psychosocial Aspects of MS
A longitudinal study of mild cognitive impairment in multiple sclerosis
Following a group of individuals with MS who have mild cognitive problems to evaluate whether this symptom becomes worse over time.
Project Number: RG 3361-A-2
Funding: $389,390
Term: 4/1/02 to 3/31/05
Category: Immunology
Sequence of events leading to the development and regulation of spontaneousEAE
Assessing the role of lymph nodes in the development of an MS-like disease in mice.
Project Number: RG 1941-E-5
Funding: $652,168
Term: 9/30/00 to 9/30/04
Category: Biology of Glia
Role of GTP-binding proteins in the regulation of myelin biogenesis
Tagging and tracking a protein in myelin-making cells to determine its function and role in the production of nerve-insulating myelin.
Project Number: PP0931
Funding: $33,000
Term: 7/1/03 to 10/31/04
Category: Biology of Glia
Taurine chloramine and inflammatory mediator induced damage ofoligodendrocytes
Investigating whether a molecule that protects against inflammation can protect myelin-making cells during an immune attack on the brain.
Project Number: RG 3363A8/1
Funding: $759,654
Term: 10/1/02 to 9/30/05
Category: Therapy/Management of MS
Oral megadose corticosteroid therapy of acute exacerbations in MS (OMEGA)
Conducting a multi-center clinical trial to compare the effectiveness of oral versus intravenous steroids to speed recovery from acute attacks of MS.
Funded in part by a gift from the NMSS New York City Chapter
Project Number: TA 3004A2
Funding: $559,189
Term: 8/1/03 to 7/31/08
Category: CNS Repair
The ability of IGF-1 to inhibit the formation of chronic demeylinated lesions
Identifying the mechanisms responsible for the destruction of myelin-making cells and nerve fibers in MS, and determining whether a natural growth factor can prevent this damage.
Project Number: RG 2569-C-5
Funding: $509,562
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Function of SHP-1 in oligodendroglia
Exploring interactions between a component of myelin-making cells and an immune chemical that may play a role in both inflammation and myelin repair in MS.
Project Number: RD 3408-A-1
Funding: $550,000
Term: 7/1/02 to 6/30/06
Category: Immunology
Bi-directional interactions between immunity and pregnancy
How the immune system is inhibited during pregnancy to allow the mother to carry a foreign fetus, and how this mechanism may be applied to treating autoimmune disease.
Project Number: FG 1513-A-1
Funding: $131,854
Term: 8/1/02 to 7/31/05
Category: Immunology
The mechanisms of adjuvant immunotherapy in EAE
How does innoculation with an infectious agent protect mice against MS-like disease, and how can this phenomenon by applied against MS?
Project Number: FG 1422-A-1
Funding: $111,120
Term: 4/1/02 to 3/31/05
Category: Immunology
Chemokine receptor expression in the central nervous system
Exploring the presence and function of immune-system molecules and their docking proteins in MS brain lesions.
Funded in part through gifts from the Manhattan Society of the NMSS New York City Chapter
Project Number: RG 2466B2/3
Funding: $474,398
Term: 4/1/00 to 9/30/04
Category: Immunology
Autoimmunity to transaldolase in MS
Determining the role of an enzyme of myelin in generating the destructive immune attack in MS.
Project Number: RG 1001J10/2
Funding: $315,761
Term: 4/1/00 to 9/30/04
Category: Immunology
Remyelination in MS and EAE: influence of immune mediators
Investigating the roles of immune-modulating chemicals in the destruction of myelin-making cells in MS.
Project Number: RG 3258A2/1
Funding: $534,823
Term: 9/30/01 to 9/30/04
Category: Immunology
The study of mRNA expression profiles in multiple sclerosis
Identifying changes in the immune systems of people with MS that may help to predict neurologic damage, disability and response to therapy.
Project Number: RG 3235-A-2
Funding: $377,768
Term: 4/1/01 to 9/30/04
Category: Biology of Glia
Identification of activated Fyn substrates in differentiating oligodendrocytes
Identifying proteins involved in the maturation of myelin-making cells, for clues to ways to stimulate myelin repair in MS.
Funded in part by a gift from the Manhattan Society and the Associates Committee of the NMSS New York City Chapter
Project Number: RG 3168A1/1
Funding: $613,687
Term: 9/30/00 to 9/30/04
Category: Neuropathology
Quantitation of blood-brain barrier permeability in MS lesion development
Using magnetic resonance imaging to track and measure MS lesion development in early stages of the disease.
Project Number: RG 2539-C-7
Funding: $351,368
Term: 9/30/00 to 9/30/04
Category: Biology of Glia
Pathology of demyelination
Studying aspects of the interaction between myelin and nerve fibers for clues to how nerve conduction may be disrupted in MS.
Project Number: RG 3439-A-9
Funding: $516,063
Term: 4/1/03 to 3/31/07
Category: Biology of Glia
Axonal-glial interactions at the paranodes
Exploring how nerve fibers and myelin interact to maintain proper nerve fiber function.
Funded in part by a gift from the NMSS New York City chapter
Project Number: RG 2311-C-6
Funding: $300,823
Term: 4/1/01 to 3/31/05
Category: Biology of Glia
Axonal regulation of myelinating glia: roles of neuregulin and signalingpathways
Determining whether growth molecules on nerve fibers play a critical role in the formation of the myelin sheathes that envelopes them.
Project Number: RG 3237-A-1
Funding: $448,737
Term: 4/1/01 to 3/31/05
Category: Immunology
Alpha/beta interferon signaling in the treatment of MS
Understanding better how interferon-beta modulates the immune response in MS-like disease.
Project Number: RG 3571-A-3
Funding: $109,955
Term: 12/1/03 to 11/30/04
Category: Therapy/Management of MS
Establishing a Multiple Sclerosis cooperative research group - a planning grantproposal
Planning the creation of a research team to conduct multi-center clinical research related to MS.
Project Number: JF 2098A1/1
Funding: $530,295
Term: 7/1/00 to 6/30/05
Category: Immunology
The role of interleukin-12 during the effector phase of EAE
Evaluating the function of a messenger chemical of the immune system and its role in stimulating the immune attack in MS-like disease.
Funded in part by the Dave Tomlinson Research Fund through the NMSS Mid- America Chapter
Project Number: RG 3020-B-4
Funding: $402,636
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Survival factors for human oligodendrocytes: implications for MS
Studying molecules that may have the power to protect myelin-making cells from dysfunction and death in MS.
Funded in full by an anonymous donor through the NMSS New York City Chapter
Project Number: PP0871
Funding: $36,000
Term: 9/1/02 to 8/31/04
Category: Psychosocial Aspects of MS
Electrophysiological measures of processing speed & working memory deficits inMS
Developing a method of measuring mild cognitive dysfunction in MS.
Project Number: PP0988
Funding: $44,000
Term: 3/1/04 to 2/28/05
Category: Neuropathology
AMPA/KA receptors & blood brain barrier integrity in MS and EAE
Determining the roles of specific molecules that may allow the immune attack to breach the brain and spinal cord in MS.
Project Number: HC 0043T
Funding: $352,044
Term: 10/1/03 to 6/30/05
Category: Health Care Delivery/Policy
The long-term care needs of people with multiple sclerosis
Exploring the longterm care needs of people with MS and the services they receive in care facilities.
Project Number: HC 0038T
Funding: $165,284
Term: 10/1/03 to 6/30/04
Category: Health Care Delivery/Policy
Delivery of health care to people with multiple sclerosis living in rural areas
Profiling how people with MS in rural areas utilize health care and barriers to access they may encounter.
Project Number: TA 3005A2
Funding: $559,189
Term: 8/1/03 to 7/31/08
Category: Immunology
Ubiquitination Regulates CIITA activity and MHC II expression on microglia
Investigating whether molecules involved in activating the immune attack help to control the onset or progression of MS.
Project Number: HC 0033T
Funding: $246,805
Term: 7/1/02 to 6/30/04
Category: Rehabilitation
Trial of rehabilitation following acute relapses of MS
Determining the value of comprehensive rehabilitation in recovery from an MS flare-up.
Project Number: FG 1482-A-1
Funding: $130,947
Term: 8/1/02 to 7/31/05
Category: Immunology
Mononuclear cell chemokine receptors: In vitro studies
Using an advanced, artificial membrane to test ways to block signals that attract destructive immune cells into the brain and spinal cord in MS.
Project Number: FG 1528-A-1
Funding: $130,947
Term: 8/1/03 to 7/31/06
Category: Immunology
Role of CX3CR1 in microglia activation in vivo: effect of inflammatory andneurotoxic stimuli
Evaluating the role of a protein docking site in modulating brain cells that are active in the immune attack on the brain and spinal cord in MS.
Project Number: FA 1445-A-1
Funding: $130,215
Term: 7/1/01 to 6/30/04
Category: Immunology
Bone marrow regeneration of autoreactivity in experimental allergicencephalomyelitis
Testing whether persistence of the immune attack in chronic MSlike disease is affected by factors in bone marrow cells.
Project Number: RG 3499-A-3
Funding: $473,042
Term: 10/1/03 to 9/30/06
Category: Immunology
The role of macrophage migration inhibitory factor (MIF) in EAE
Evaluating the role of an immune messenger protein that may contribute to the immune attack in an MS-like disease in mice by prolonging the life of inflammatory immune cells.
Project Number: RG 3322A2/2
Funding: $178,296
Term: 10/1/02 to 9/30/05
Category: Immunology
Avidity maturation of T cells in multiple sclerosis
Identifying the protein target of immune T cells and their activity in the development of MS.
Project Number: FP 1521-A-1
Funding: $120,500
Term: 8/1/03 to 7/31/06
Category: Therapy/Management of MS
Sylvia Lawry Physician Fellowship
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: PP0944
Funding: $44,000
Term: 9/1/03 to 8/31/04
Category: CNS Repair
Mechanisms of oligodendrocyte adhesion and migration: modulation byglutamate
Understanding the mechanisms that control movement of myelin-making cells, for clues to enhancing myelin repair.
Project Number: RG 3290A6/1
Funding: $461,129
Term: 4/1/02 to 3/31/05
Category: Biology of Glia
Neuregulin function in oligodendrocytes
Understanding how proteins on the surface of nerve fibers influence the growth and survival of myelin-making cells.
Project Number: FP 1424-A-1
Funding: $120,500
Term: 7/1/01 to 6/30/04
Category: Psychosocial Aspects of MS
Effects of cognitive impairment on the validity of a patient self-report measure
Receiving training on the proper ways to conduct clinical treatment trials in MS.
Project Number: FA 1507A1/1
Funding: $154,745
Term: 8/1/03 to 7/31/06
Category: Neuropathology
Identification of genes involved in neuronal pathology in multiple sclerosis
Understanding the mechanisms that lead to nerve cell injury in MS, and identifying strategies to protect these cells.
Project Number: PP0913
Funding: $44,000
Term: 5/1/03 to 4/30/04
Category: Neuropathology
Proteolipid protein expression in neurons in the developing brainstem
Exploring the role that a myelin protein may play in the development of nerve cells, and in their injury in MS.
Project Number: FA 1459-A-1
Funding: $148,555
Term: 7/1/01 to 6/30/04
Category: Immunology
Gender differences in immune responses in multiple sclerosis
Investigating differences in immune responses against nerve-insulating myelin between men and women with MS.
Project Number: FA 1464-A-1
Funding: $147,556
Term: 7/1/01 to 6/30/04
Category: Biology of Glia
The molecular mechanisms that control myelination
Determining mechanisms involved in myelin formation for clues to stimulating myelin repair in MS.
Funded in part by the NMSS Ohio Valley Chapter
Project Number: FG 1555-A-1
Funding: $148,265
Term: 8/1/03 to 7/31/06
Category: Immunology
Biased antigen presenting cells influence autoimmune T cells: Implications forEAE
Investigating how cells that activate the immune attack can influence the formation of inflammatory or suppressive immune cells, and the possible treatment benefits in an MS-like disease in mice.
Project Number: RG 3263-A-3
Funding: $251,190
Term: 4/1/01 to 9/30/04
Category: Immunology
Gender differences in immune responses in MS
Determining in what ways the immune attack that leads to MS is different in men and women who have the disease.
Project Number: RG 3005-B-4
Funding: $479,190
Term: 4/1/04 to 3/31/07
Category: Immunology
Longitudinal immune- and neurotrophic-cytokine responses in MS
Correlating immune activity during MS attacks with clinical/MRI measures MS and progression.
Project Number: PP0857/T
Funding: $7,644
Term: 5/1/02 to 4/30/04
Category: Immunology
Study of MCP-1 expression in transgenic animal models
Developing new tools to understand how immune cells are attracted to enter and damage brain and spinal cord tissue in MS-like disease.
Project Number: RG 3099-A-4
Funding: $515,092
Term: 9/30/99 to 9/30/04
Category: Measuring Disease Activity
Monitoring brain atrophy during the course of multiple sclerosis
Using magnetic resonance techniques to measure nervous tissue destruction in MS, to improve methods of testing new therapies.
Project Number: HC 0046
Funding: $437,790
Term: 7/1/01 to 6/30/04
Category: Health Care Delivery/Policy
MS employment project
Assessing the employment concerns and needs of people with MS using a national survey.
Project Number: RG 3223A2/1
Funding: $401,859
Term: 9/30/01 to 9/30/04
Category: Measuring MS Disease Activity
The predictive value of MRI in multiple sclerosis
Determining whether specific methods of MRI can predict the onset of disability in people with MS.
Project Number: CA 1032-A-5
Funding: $825,000
Term: 4/1/04 to 3/31/09
Category: CNS Repair
Collaborative MS Research Center Award
Searching for ways to stimulate immature cells that may generate new nerve-insulating myelin after it is destroyed by MS.
Project Number: RG 3435-A-3
Funding: $149,573
Term: 4/1/03 to 3/31/06
Category: Immunology
Mechanism of EAE suppression with non-steroidal estrogens
Exploring the use of a plant-derived hormone similar to estrogen to treat an MS-like disease in mice, for clues to its possible use in humans.
Project Number: PP0921
Funding: $44,000
Term: 5/1/03 to 4/30/04
Category: Psychosocial Aspects of MS
Ginkgo biloba as symptomatic therapy for cognitive dysfunction in multiplesclerosis
Conducting a clinical trial to assess a method of treating cognitive problems in MS.
Project Number: RG 3259A1/1
Funding: $423,017
Term: 9/30/01 to 9/30/04
Category: Immunology
Molecular interactions of myelin basic protein-specific T cell receptor
Determining how immune cells recognize their myelin protein targets during the attack in MS-like disease.
Project Number: PP0848
Funding: $33,000
Term: 2/1/02 to 1/31/05
Category: Rehabilitation
Fracture risk, fall risk, falls and bone density in women with multiple sclerosis
Defining physical and psychological factors that may predict falls in women with MS.
Project Number: RD 3405-A-2
Funding: $641,268
Term: 8/1/02 to 7/31/06
Category: Immunology
Immunoregulatory effects of estrogen in EAE
Determining how the female sex hormone estrogen inhibits immune-system responses in an MS-like disease in mice.
Project Number: PP0975
Funding: $44,000
Term: 2/1/04 to 1/31/05
Category: Biology of Glia
Role of hyaluronan in inhibition of remyelination
Exploring a molecule that may inhibit myelin repair in MS, for clues to developing treatments aimed at myelin repair.
Project Number: RG 3468A5/1
Funding: $542,398
Term: 4/1/04 to 3/31/07
Category: Immunology
Epitope specific regulation of EAE with recombinant TCR ligands
Developing a highly targeted experimental therapy that aims to inhibit only those immune T cells involved in MS attacks.
Project Number: RG 3400A4/1
Funding: $469,902
Term: 4/1/03 to 3/31/06
Category: Immunology
T cell receptor-specific regulatory T cells in multiple sclerosis
Understanding the regulation of immune cells in MS, and the role of an experimental peptide therapy to control damage.
Project Number: PP0898
Funding: $44,000
Term: 1/1/03 to 6/30/04
Category: Immunology
Are alpha-B crystallin-specific T cells from gene knock-out miceencephalitogenic?
Defining the role of a myelin-related protein in the immune attack on myelin in an MS-like disease in mice.
Project Number: PP0972
Funding: $44,000
Term: 2/1/04 to 1/31/05
Category: Psychosocial Aspects of MS
Mindfulness-based stress management for people with MS and their caregivers
Examining the effects of a stress reduction strategies in people with MS and their caregivers.
Project Number: RG 3428A2/1
Funding: $34,619
Term: 10/1/03 to 9/30/08
Category: Measuring MS Disease Activity
Longitudinal assessment of visual function in multiple sclerosis
Tracking changes in visual function and quality of life over time in people with MS, and identifying the best methods for vision testing in MS clinical trials.
Project Number: RG 3208-A-1
Funding: $607,749
Term: 9/30/00 to 9/30/05
Category: Measuring MS Disease Activity
Vision, MRI lesion burden, and quality of life in MS
Exploring vision loss in people with MS and how it relates to other neurologic functions and quality of life.
Project Number: RG 3276-A-4
Funding: $405,999
Term: 9/30/01 to 9/30/04
Category: Immunology
Correlation of immune response phenotypes with EAE genetic susceptibility
Linking genes that make mice susceptible to developing an MS-like disease to specific types of immune-system responses.
Project Number: FA 1431-A-1
Funding: $149,055
Term: 7/1/01 to 6/30/04
Category: Neuropathology
The role of gap junctions in mouse hepatitis virus (MHV) induceddemyelination
Exploring the idea that communication between cells in the brain can be disrupted by viral infection in MS-like disease.
Project Number: FG 1490A1/1
Funding: $141,771
Term: 1/1/04 to 12/31/06
Category: Biology of Glia
Visualizing abnormal axonal conduction at the single cell level
Developing a method of visualizing abnormalities in nerve fibers that may lead to abnormal nerve impulse conduction, for clues to improving nerve conduction in MS.
Project Number: RG 3570A1/T
Funding: $67,410
Term: 5/1/03 to 7/31/05
Category: Immunology
Role of IL-12 and IL-12 receptor in the pathogenesis of EAE
Determining the complex role of a key immune messenger protein in the immune attack in MS-like disease.
Project Number: RG 3419A1/1
Funding: $411,678
Term: 10/1/03 to 9/30/06
Category: Biology of Glia
Regulation of oligodendroglial death by the Bc1 family
Analyzing how certain proteins affect the survival of myelin-making cells, to improve understanding of how these cells are damaged in MS.
Project Number: RG 2829B3/1
Funding: $386,681
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Roles of ciliary neurotrophic factor in remyelination
Studying a molecule that may provide signals the promote myelin repair in an MS-like disease in mice.
Project Number: PP0987
Funding: $44,000
Term: 3/1/04 to 2/28/05
Category: Neuropathology
The ability of T-lymphocytes to induce axonal degeneration
Investigating the role of immune cells in the damage to nerve fibers in models of MS.
Project Number: RG 3523-A-3
Funding: $400,382
Term: 4/1/04 to 3/31/07
Category: Biology of Glia
Excitotoxicity in experimental allergic encephalomyelitis
The role of overstimulation of nerve and myelin-making cells in MS tissue damage, and whether it can be blocked to treat the disease.
Project Number: RG 2991A1/1
Funding: $147,890
Term: 4/1/04 to 3/31/05
Category: Immunology
Mechanisms of tolerance induced by i.v. MBP in EAE
Teaching the immune system to tolerate nerve-insulating myelin, with an aim to suppressing the MSassociated immune attack.
Project Number: RG 2079-D-6
Funding: $301,562
Term: 10/1/02 to 9/30/05
Category: Biology of Glia
Molecular analysis of myelin basic protein gene expression
Understanding the genetic control of a protein in nerve-insulating myelin, and its function in myelin growth and repair.
Project Number: RG 3293-A-5
Funding: $327,403
Term: 9/30/01 to 9/30/04
Category: Biology of Glia
Cell cycle control in oligodendrocyte development
Examining the role of a protein in the development of myelin-making cells and the formation of myelin.
Project Number: RG 3420-A-1
Funding: $385,761
Term: 4/1/03 to 3/31/06
Category: Biology of Glia
Control of oligodendrocyte proliferation & differentiation by notch signaling
Investigating the molecular mechanisms that regulate the development of myelinmaking cells, for clues to repairing tissue damage caused by MS.
Project Number: FG 1540-A-1
Funding: $141,771
Term: 8/1/03 to 7/31/06
Category: Measuring MS Disease Activity
Expression of pro-survival genes in multiple sclerosis
Examining patterns of genes that regulate immune cell survival in people with MS and in their family members for clues to understanding the persistence of the immune attack.
Project Number: FA 1468-A-1
Funding: $135,469
Term: 7/1/01 to 6/30/04
Category: Immunology
Role of peroxisome proliferator-activated receptors in CNS autoimmunedemyelination
Evaluating the immune effects of a novel compound and whether it can suppress inflammation and inhibit MS-like disease in mice.
Project Number: JF 2118-A-2
Funding: $638,000
Term: 1/1/04 to 12/31/08
Category: Immunology
Therapeutic modulation of autoreactive T cell responses in multiple sclerosis
Characterizing specific immune responses mounted by different subtypes of immune cells in people with MS, for clues to stopping the attack.
Project Number: JF 2115-A-1
Funding: $576,760
Term: 8/1/03 to 7/31/08
Category: Biology of Glia
Genetic mechanisms of oligodendrocyte development
Understanding the mechanisms involved in the development of cells that make nerve-insulating myelin, to facilitate therapeutic strategies that will stimulate myelin repair in MS.
Project Number: RG 3267-A-1
Funding: $298,673
Term: 4/1/01 to 3/31/05
Category: Immunology
Molecular analysis of the Ig repertoire in MS
Determining if immune cells produce significant antibodies that mark myelin and nerve cells for attack in MS.
Project Number: RG 3427-A-8
Funding: $418,011
Term: 4/1/03 to 3/31/06
Category: Immunology
Peroxisome proliferator-activated receptor agonists as treatment forautoimmune demyelination
Testing whether anti-inflammatory molecules can improve an MS-like disease in mice, for clues to a new approach to treating MS in humans.
Project Number: RG 2969-B-7
Funding: $103,320
Term: 10/1/02 to 9/30/06
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