All About Multiple Sclerosis

More MS news articles for March 2004

List of Current Research Projects Funded by the National MS Society

http://www.nationalmssociety.org/pdf/research/GrantsList.pdf

Spring 2004
Research Programs Department
National Multiple Sclerosis Society

[To give a better idea of which areas the NMSS research grants are concentrated, I have taken the liberty of analysing the number of projects per stated category. This is shown in the following table:
 
Category Number of Projects
Biochemistry/Biophysics 3
Biology of Glia 63
CNS Repair 18
Diagnostic Methods 1
Epidemiology 3
Health Care 8
Human Genetics 12
Immunology 119
Infectious Agents 7
MS Therapy/Management 1
Measuring Disease Activity 2
Measuring MS Disease 11
Neuropathology 18
Neuropharmacology 1
Neurophysiology 6
Psychosocial Aspects of MS 13
Rehabilitation 10
Therapy/Management of MS 13
Tissue/DNA Banks 2
Total 311

Introduction

This document lists, by state and country, all current MS research projects being funded by the National Multiple Sclerosis Society as of April 1, 2004.

Key

The project number for each project is preceded by a program code, as follows:

RG – full grants for basic, clinical and rehabilitation research;
RD – full grants co-funded by a collaborative funding agreement with NIH to support a targeted research initiative on gender differences in MS;
CA – Collaborative MS Research Center Awards - five-year awards to help stimulate creativity and interaction among investigators working within and outside MS fields;
TA – career transition fellowships, awards to facilitate the advancement of promising young investigators into full faculty positions;
FG & FA – postdoctoral fellowships, advanced postdoctoral fellowships, respectively – research projects by young or more advanced investigators, working under the mentorship of senior scientists, to provide training and experience in MS research;
FP – physician fellowships, young doctors working under the mentorship of seasoned clinicians, to provide training and experience in conducting clinical trials in people with MS;
JF – Harry Weaver Neuroscience Scholarships – special five-year projects by promising young investigators just starting their careers as independent researchers;
PP – high-risk pilot research grants, aimed at exploring new, untested ideas;
HC – health care delivery and policy contracts initiated by the Society and awarded on a competitive basis to investigators studying subjects identified as mission priorities.
You will find for selected projects an indication of restricted support that has been provided from individuals, groups, families, or chapters to underwrite the project. This is listed in italic typeface directly beneath the project title. It is through the generous support of individual donors and National MS Society chapters that the Society funds more MS research, offers more services for people with MS, and provides more professional education programs than any other MS organization in the world.

PROJECTS BY STATE AND CHAPTER TERRITORY

ALABAMA
ARKANSAS
CALIFORNIA
COLORADO
CONNECTICUT
DISTRICT OF COLUMBIA
FLORIDA
GEORGIA
ILLINOIS
IOWA
KANSAS
KENTUCKY
MARYLAND
MASSACHUSETTS
MICHIGAN
MINNESOTA
MISSOURI
NEBRASKA
NEW HAMPSHIRE
NEW JERSEY
NEW MEXICO
NEW YORK
NORTH CAROLINA
OHIO
OREGON
PENNSYLVANIA
SOUTH DAKOTA
TENNESSEE
TEXAS
UTAH
VERMONT
VIRGINIA
WASHINGTON
WISCONSIN
INTERNATIONAL GRANTS


ALABAMA

J. Edwin Blalock, Ph.D. University of Alabama at Birmingham Birmingham, AL

Project Number: RG 2667B8/1T

Funding: $354,506

Term: 10/1/01 to 9/30/04

Category: Measuring Disease Activity

“p-Cresol sulfate and MS”

Developing a lab test of body fluids that may permit monitoring of a person's MS disease activity. 


Laurie Harrington, Ph.D. University of Alabama at Birmingham Birmingham, AL

Project Number: FG 1501-A-1

Funding: $120,382

Term: 12/1/02 to 11/30/05

Category: Immunology

“Defining the roles of P-and E-selectin during CD4 T cell migration”

How specific molecules help escort damaging immune cells into the brain and spinal cord in MS-like disease, for insights into preventing disease. 


ARKANSAS
Paul Drew, Ph.D.
University of Arkansas for Medical Sciences Little Rock, AR

Project Number: RG 3198A1/1

Funding: $330,000

Term: 4/1/01 to 3/31/05

Category: Biology of Glia

“Female sex steroids: effects on glia”

Determining mechanisms by which certain sex hormones may protect myelin-making cells. 


Patricia Wight, Ph.D. University of Arkansas for Medical Sciences Little Rock, AR

Project Number: RG 2705C3/1

Funding: $359,276

Term: 10/1/02 to 9/30/05

Category: Biology of Glia

“Developmental control of myelin proteolipid protein gene regulation”

Exploring genetic factors that dictate the development of a specific protein in nerve-insulating myelin, for clues to stimulating myelin repair in MS. 


CALIFORNIA
Katerina Akassoglou, Ph.D. University of California at San Diego La Jolla, CA

Project Number: RG 3370A1/T

Funding: $217,413

Term: 10/1/03 to 9/30/05

Category: CNS Repair

“Fibrin in demyelination and remyelination”

Exploring whether fibrin, a molecule found in MS brain lesions, may inhibit myelin repair, and whether its activity can be reversed to foster recovery. 


Ben Barres, M.D., Ph.D. Stanford University Medical Center Palo Alto, CA

Project Number: RG 2553D5/1

Funding: $457,885

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“The development of nodes of Ranvier in the central nervous system”

Understanding how myelin-making cells influence nerve fiber development, for clues to restoring nerve conduction in MS. 


Christine Beeton, Ph.D. University of California, Irvine Irvine, CA

Project Number: FG 1454-A-1

Funding: $111,120

Term: 8/1/01 to 7/31/04

Category: Immunology

“Therapy of autoimmune diseases by lymphocyte potassium channel blockers”

Determining whether blocking ion channels in immune cells can improve MS-like disease in mice. 


Anthony Campagnoni, Ph.D. University of California at Los Angeles Los Angeles, CA

Project Number: RG 2693-C-6

Funding: $132,915

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Golli MBP gene expression in the nervous system”

Studying the functions of a specific protein that may be involved in the growth, destruction and regeneration of nerve-insulating myelin.

Funded in full by a gift from the NMSS Southern California Chapter 


K. George Chandy, M.B.B.S., Ph.D. University of California, Irvine Irvine, CA

Project Number: RG 3343-A-2

Funding: $389,410

Term: 4/1/02 to 3/31/05

Category: Immunology

“Lymphocyte ion channel: novel therapeutic targets for multiple sclerosis”

Attempting to stop MS-like disease by blocking pore-like ion channels on the surface of immune cells that target myelin. 


Bruce Cree, M.D., Ph.D. University of California at San Francisco San Francisco, CA

Project Number: FP 1430A1/1

Funding: $120,000

Term: 8/1/02 to 7/31/05

Category: MS Therapy/Management

“Sylvia Lawry Physician Fellowship”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


Stephen Crocker, Ph.D. The Scripps Research Institute La Jolla, CA

Project Number: FA 1552-A-1

Funding: $154,745

Term: 8/1/03 to 7/31/06

Category: Immunology

“Molecular regulation of TIMP-1 gene expression and its role in CNSinflammation”

Understanding molecular signals that may help to control active players in the inflammation that occurs in MS-like disease in mice. 


Michael David, Ph.D. University of California at San Diego La Jolla, CA

Project Number: RG 3338-A-1

Funding: $311,365

Term: 4/1/02 to 3/31/05

Category: Immunology

“Protective role of STAT1 in EAE development”

How a signaling molecule may prevent MS-like disease and its symptoms, and how it influences immune activity, for clues to new approaches to treating MS. 


Ralph Feuer, Ph.D. The Scripps Research Institute La Jolla, CA

Project Number: FA 1551-A-1

Funding: $154,745

Term: 3/1/04 to 2/28/07

Category: Infectious Agents

“The characterization of T cell responses and immuno-pathology during latentcoxsackievirus infection in the CNS”

Identifying the role of a virus in triggering an immune attack and myelin damage in the central nervous system, as a possible model of what occurs in MS. 


Claude Genain, M.D. University of California at San Francisco San Francisco, CA

Project Number: PP0916

Funding: $44,000

Term: 5/1/03 to 4/30/04

Category: Infectious Agents

“in vivo models for replication and pathogenesis of human herpes virus”

Investigating a possible role for herpesvirus in the development of myelin damage such as that which occurs in MS. 


Claude Genain, M.D. University of California at San Francisco San Francisco, CA

Project Number: RG 3438-A-7

Funding: $258,213

Term: 4/1/03 to 3/31/05

Category: Measuring MS Disease Activity

“Pathophysiological significance of autoantibodies to myelin”

Characterizing immune antibodies that play a role in the destruction of nerve-insulating myelin in MSlike disease. 


Claude Genain, M.D. University of California at San Francisco San Francisco, CA

Project Number: RG 3320-A-3

Funding: $505,178

Term: 9/30/01 to 9/30/04

Category: Immunology

“Molecular analysis of demyelinating antibody responses in EAE”

Characterizing immune antibodies that play a role in the destruction of nerve-insulating myelin in MSlike disease. 


Barbara Giesser, M.D. University of California at Los Angeles Los Angeles, CA

Project Number: PP0927

Funding: $44,000

Term: 7/1/03 to 6/30/04

Category: Rehabilitation

“Locomotor training using body weight support on a treadmill in people with MS”

Investigating the effectiveness of an exercise regimen in improving mobility in MS. 


Alan Goldin, M.D., Ph.D. University of California at Irvine Irvine, CA

Project Number: RG 3405A3/1

Funding: $449,783

Term: 10/1/03 to 9/30/06

Category: Neurophysiology

“Mechanisms of sodium channel localization in neuronal cells”

Understanding tiny pores on the surface of nerve cells that aid nerve signaling, and how MS alters them. 


Jaewon Han, Ph.D. The Scripps Research Institute La Jolla, CA

Project Number: FA 1498-A-1

Funding: $101,003

Term: 8/1/02 to 10/31/04

Category: Immunology

“Regulation of T lymphocyte function through the a4 cytoplasmic domain”

Understanding the role of a molecule on the surface of immune T cells in the development of MS. 


Stephen Hauser, M.D. University of California at San Francisco San Francisco, CA

Project Number: RG 2899-B-7

Funding: $1,334,708

Term: 4/1/02 to 3/31/07

Category: Human Genetics

“Establishment of a core DNA repository for multiple sclerosis”

Collecting genetic material from individuals and from families with multiple members who have MS, as a shared resource for studies searching for genes that confer susceptibility to MS. 


Roland Henry, Ph.D. University of California at San Francisco San Francisco, CA

Project Number: RG 3240A1/1

Funding: $656,018

Term: 9/30/01 to 9/30/06

Category: Neuropathology

“Diffusion tensor imaging in multiple sclerosis”

Exploring the potential of a novel imaging technology in people in the earliest stages of MS. 


Laura Julian, Ph.D. University of California at San Francisco San Francisco, CA

Project Number: FG 1481-A-1

Funding: $142,771

Term: 8/1/02 to 7/31/05

Category: Psychosocial Aspects of MS

“Early detection of neuropsychological and psychiatric symptom in multiplesclerosis”

Determining the presence of cognitive and emotional symptoms early in the course of MS, to improve their detection and treatment. 


Vipin Kumar, Ph.D. Torrey Pines Institute for Molecular Studies San Diego, CA

Project Number: RG 2765B3/T

Funding: $399,963

Term: 10/1/02 to 9/30/05

Category: Immunology

“T cell receptor peptide-specific T cells in regulation of murine EAE”

Exploring immune-system mechanisms involved in turning off the immune attack in MS-like disease in mice, for their potential role in treating MS. 


Patrice Lalive d'Epinay, M.D. University of California at San Francisco San Francisco, CA

Project Number: FG 1562-A-1

Funding: $111,984

Term: 12/1/03 to 11/30/05

Category: Immunology

“Molecular and functional heterogeneity of the MOG antibody repertoires”

Understanding how immune responses focused against a specific protein in myelin may contribute to the development of MS. 


Thomas Lane, Ph.D. University of California, Irvine Irvine, CA

Project Number: RG 3278-A-3

Funding: $236,801

Term: 9/30/01 to 9/30/04

Category: Immunology

“Chemokines & chemokine receptors and their roles in viral-induceddemyelination”

Investigating factors that regulate how immune cells invade the central nervous system in MS-like disease. 


Wim Mandemakers, Ph.D. Stanford University Medical Center Palo Alto, CA

Project Number: FG 1434-A-1

Funding: $120,375

Term: 1/1/02 to 12/31/04

Category: CNS Repair

“The identification of novel CNS myelin-associated proteins that inhibit axonoutgrowth”

Looking for proteins in nerve fiber-insulating myelin that may inhibit the regeneration of nerve fibers in MS.

Funded in full by a gift from the Alan Buegeleisen Research Fund, in honor of Sylvia Lawry 


Til Menge, M.D. University of California at San Francisco San Francisco, CA

Project Number: FG 1476-A-1

Funding: $143,860

Term: 10/1/01 to 9/30/04

Category: Immunology

“Structural basis for antibody responses to myelin/oligodendrocyte glycoprotein”

Characterizing the molecular structure and immune response to a protein in myelin that may be a target for the immune attack in MS. 


Joonmi Oh, Ph.D. University of California at San Francisco San Francisco, CA

Project Number: FG 1514-A-1

Funding: $141,771

Term: 8/1/02 to 7/31/05

Category: Measuring MS Disease Activity

“T2 relaxation time measurement of spinal cord & brain for people with MS”

Developing and applying new ways to analyze imaging techniques to study spinal cord damage in persons with MS. 


Jorge Oksenberg, Ph.D. University of California at San Francisco San Francisco, CA

Project Number: RG 2901C6/1

Funding: $401,194

Term: 4/1/04 to 3/31/06

Category: Human Genetics

“Genetic mapping in multiple sclerosis”

Attempting to pinpoint genes that may be involved in determining MS susceptibility, progression and other disease characteristics. 


Jorge Oksenberg, Ph.D. University of California at San Francisco San Francisco, CA

Project Number: RG 3060-B-5

Funding: $363,888

Term: 10/1/02 to 9/30/05

Category: Human Genetics

“Family-based genetic studies in ethnically distinct MS population”

Searching for MS susceptibility genes by studying genetic material from families with distinct ethnic backgrounds. 


Shalina Ousman, Ph.D. The Scripps Research Institute La Jolla, CA

Project Number: FG 1494-A-1

Funding: $107,462

Term: 8/1/02 to 7/31/05

Category: Immunology

“Role of interferon-gamma & its signaling pathways in IL-12-induced immunedisease of the CNS”

Determining the activity and interactions of messenger chemicals that facilitate the immune attack in MS and may be suitable therapeutic targets. 


Leena Peltonen, Ph.D. University of California at Los Angeles Los Angeles, CA

Project Number: RG 3050-B-2

Funding: $298,066

Term: 10/1/02 to 9/30/05

Category: Human Genetics

“Characterization of genetic loci predisposing to multiple sclerosis”

Searching for genetic abnormalities that may contribute to making persons susceptible to developing MS. 


Barbara Ranscht, Ph.D. The Burnham Institute La Jolla, CA

Project Number: RG 3567-A-1

Funding: $419,918

Term: 4/1/04 to 3/31/07

Category: Neurophysiology

“Formation and maintenance of paranodal axoglial junctions in myelinatednerve”

Molecular interactions between nerve fibers and myelin which are crucial to the health of both and which may be future targets for MS therapy. 


William Reed, M.D. Blood Centers of the Pacific San Francisco, CA

Project Number: PP0928

Funding: $44,000

Term: 6/1/03 to 5/31/04

Category: Immunology

“Is microchimerism associated with multiple sclerosis?”

Determining if the sharing of cells between mothers and offspring is associated with MS. 


Eli Sercarz, Ph.D. Torrey Pines Institute for Molecular Studies San Diego, CA

Project Number: RG 2643C8/T

Funding: $427,185

Term: 10/1/02 to 9/30/05

Category: Immunology

“The role of driver clones in autoimmunity”

Studying a type of immune cell that may drive MS, and attempting to protect mice with an MS-like disease from these cells. 


Nancy Sicotte, M.D. University of California at Los Angeles Los Angeles, CA

Project Number: JF 2107-A-1

Funding: $512,867

Term: 7/1/01 to 6/30/06

Category: Measuring MS Disease Activity

“The onset of progressive MS: structural and functional determinants”

Using brain imaging as a way to observe the process by which relapsing-remitting MS becomes progressive disease. 


Lawrence Steinman, M.D. Stanford Medical Center Palo Alto, CA

Project Number: RG 3516-A-8

Funding: $579,374

Term: 4/1/04 to 3/31/07

Category: Immunology

“Targeting allergy pathways in MS/EAE”

Exploring whether and how antihistamine drugs inhibit MS-like disease and the implications for treating multiple sclerosis. 


William Talbot, Ph.D. Stanford University Medical Center Palo Alto, CA

Project Number: RG 3344-A-1

Funding: $308,844

Term: 4/1/02 to 3/31/05

Category: Biology of Glia

“Genetic mechanisms of myelination”

Searching for the genes that control the development and repair of the myelin that insulates nerve fibers and which is targeted in MS. 


Seema Tiwari-Woodruff, Ph.D. University of California at Los Angeles Los Angeles, CA

Project Number: RG 3355-A-1

Funding: $351,496

Term: 4/1/02 to 3/31/05

Category: Biology of Glia

“Role of a potassium channel, Kv3.1, and its interaction with a myelin membraneprotein”

Exploring the role of a tiny pore on the surface of myelin-making cells, called a potassium channel, in the development of nerve-insulating myelin. 


Wallace Tourtellotte, M.D., Ph.D. Veterans Administration Medical Center Los Angeles, CA

Project Number: RG 829-N-38

Funding: $633,900

Term: 9/30/01 to 9/30/04

Category: Tissue/DNA Banks

“Human Brain and Spinal Fluid Resource Center”

Developing and maintaining a tissue bank of tissue specimens from people with MS for use in research. 


Roel VanderVeen, Ph.D. University of Southern California Los Angeles, CA

Project Number: PP0941

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: Immunology

“Extracellular superoxide dismutase in the regulation of immune responses inEAE”

Determining the role of a molecule that may be able to inhibit the immune attack in an MS-like disease. 


Roel VanderVeen, Ph.D. University of Southern California Los Angeles, CA

Project Number: RG 3222A8/2

Funding: $479,780

Term: 9/30/01 to 9/30/04

Category: Immunology

“Regulation of immune responses by nitric oxide”

Examining the role of a molecule that may prove to be an important regulator of the immune attack in MS. 


Rhonda Voskuhl, M.D. University of California at Los Angeles Los Angeles, CA

Project Number: RD 3407-A-8

Funding: $495,000

Term: 8/1/02 to 7/31/06

Category: Immunology

“Mechanisms underlying the protective effect of pregnancy doses of estrogens inEAE”

Studying the effects of the sex hormone estrogen on immune-system responses in mice with MS-like disease for clues to its potential use to treat human MS. 


Rhonda Voskuhl, M.D. University of California at Los Angeles Los Angeles, CA

Project Number: RG 3239A7/2

Funding: $675,616

Term: 4/1/02 to 3/31/05

Category: Therapy/Management of MS

“Testosterone treatment for multiple sclerosis: a preliminary trial”

Testing whether the male sex hormone, testosterone, is safe and can produce positive immunesystem and disease changes in men who have MS. 


Leslie Weiner, M.D. University of Southern California Los Angeles, CA

Project Number: RG 3021A1/1

Funding: $1,313,891

Term: 4/1/99 to 9/30/04

Category: Therapy/Management of MS

“T cell vaccine: a clinical trial for progressive MS”

Testing an experimental treatment in people with progressive MS that specifically kills immune cells that “recognize” and launch attacks against myelin.

Funded in part by a gift from Brenda Earl and Mike De Paola through the NMSS New York City Chapter 


Heike Wulff, Ph.D. University of California, Davis Davis, CA

Project Number: PP0946

Funding: $44,000

Term: 8/1/03 to 7/31/04

Category: Immunology

“Design of a small molecule blocker as a therapeutic for multiple sclerosis”

Developing compounds that may prove effective in treating MS.

Paid in full by funds raised by the QVC Cure by the Shore in collaboration with the NMSS Southern California Chapter 


Jung-Hua Yeh, Ph.D. Stanford University Palo Alto, CA

Project Number: FG 1535-A-1

Funding: $130,947

Term: 8/1/03 to 7/31/06

Category: Immunology

“The involvement of self-reactive T cells in autoimmune neurological disease”

Studying a rodent model of myelin damage for clues to how an immune attack may cause this damage in MS. 


Sawsan Youssef, Ph.D. Stanford University Medical Center Palo Alto, CA

Project Number: FA 1549-A-1

Funding: $148,265

Term: 8/1/03 to 7/31/06

Category: Immunology

“Mechanisms for immune modulation by statin treatment of CNS autoimmunedisease”

Examining mechanisms responsible for the ability of cholesterol-lowering “statin” drugs to modulate the immune attack in MS-like disease in mice. 


Scott Zamvil, M.D., Ph.D. University of California at San Francisco San Francisco, CA

Project Number: RG 3206B4/1

Funding: $461,291

Term: 10/1/03 to 9/30/06

Category: Immunology

“MHC class II regulation and antigen presentation in CNS autoimmunity”

Evaluating the role of an immune-modulating molecule that may contribute to inflammation in MS and susceptibility to the disease. 


COLORADO
Allen Bowling, M.D., Ph.D.
Rocky Mountain MS Center Englewood, CO

Project Number: RG 2859C8/T

Funding: $180,640

Term: 1/1/03 to 9/30/04

Category: Tissue/DNA Banks

“Rocky Mountain Multiple Sclerosis Center Tissue Bank”

Collecting and maintaining a bank of human MS tissue specimens as a resource for scientists studying MS. 


Robert Eckel, M.D. University of Colorado Health Sciences Center Denver, CO

Project Number: PP0961

Funding: $44,000

Term: 11/1/03 to 10/31/04

Category: CNS Repair

“Lipoprotein lipase and nerve myelination”

Exploring a possible role for an enzyme in myelin repair in an MS-like disease in mice. 


S. Rock Levinson, Ph.D. University of Colorado Health Science Center Denver, CO

Project Number: RG 3448-A-1

Funding: $489,146

Term: 4/1/03 to 3/31/06

Category: Neurophysiology

“Selective targeting of sodium channel isoforms in neurons”

Identifying mechanisms by which myelin-making cells may help to maintain healthy nerve impulse conduction. 


Jack Simon, M.D., Ph.D. University of Colorado Health Science Center Denver, CO

Project Number: RG 3307-A-1

Funding: $319,972

Term: 9/30/01 to 9/30/04

Category: Neuropathology

“Neuronal tract degeneration in the earliest stages of multiple sclerosis”

Exploring damage to nerve fibers that may occur in people in the earliest stages of MS using advanced brain imaging techniques. 


Michael Thaut, Ph.D. Colorado State University Fort Collins, CO

Project Number: PP0971

Funding: $44,000

Term: 2/1/04 to 1/31/05

Category: Rehabilitation

“Enhancing verbal memory in MS with music: an EEG study”

Testing the effectiveness of a musical technique to improve memory in people with MS. 


Xiaoli Yu, Ph.D. University of Colorado Health Science Center Denver, CO

Project Number: PP0959

Funding: $44,000

Term: 2/1/04 to 1/31/05

Category: Immunology

“Identification of MS antigens with recombinant antibodies cloned from MS CSFB cells”

Developing a method of identifying the agent or agents that trigger the immune attack in MS. 


CONNECTICUT

Elisa Barbarese, Ph.D. University of Connecticut Health Center Farmington, CT

Project Number: RG 2843B3/1

Funding: $343,451

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Localization of mRNAs in oligodendrocytes”

Studying the genetic signals that control growth of proteins in nerve-insulating myelin, to find ways of stimulating myelin repair.

Funded in part by a gift from the NMSS Ohio Valley Chapter 


Angelique Bordey, Ph.D. Yale University New Haven, CT

Project Number: PP0963

Funding: $44,000

Term: 1/1/04 to 12/31/04

Category: Biology of Glia

“Ion channels and GABA receptors in glial progenitors of the subventricularzone”

Studying cells that represent a potential resource for repairing myelin damage in MS. 


Jeffery Kocsis, Ph.D. Yale University School of Medicine New Haven, CT

Project Number: CA 1009A10/1

Funding: $825,000

Term: 4/1/04 to 3/31/09

Category: CNS Repair

“Collaborative MS Research Center Award”

Exploring tissue damage in MS and testing ways to protect and repair central nervous system tissue. 


Jeffery Kocsis, Ph.D. Yale University School of Medicine New Haven, CT

Project Number: RG 2135-E-9

Funding: $566,416

Term: 10/1/02 to 9/30/06

Category: CNS Repair

“Systemic delivery of bone marrow cells to repair demyelinated spinal cord”

Attempting to restore nerve-insulating myelin in the spinal cords of mice by injecting cells from bone marrow, and testing for signs of recovery.

Funded in part by a Research Honor Roll donation by the NMSS Western Connecticut Chapter 


Cecilia Marta, Ph.D. University of Connecticut Health Center Farmington, CT

Project Number: FG 1423A1/1

Funding: $142,771

Term: 8/1/02 to 7/31/05

Category: Biology of Glia

“MOG signaling in oligodendrocytes via lipid rafts”

Examining how a protein component of nerve-insulating myelin functions for insights into how it might become a target for immune attack in MS. 


Akiko Nishiyama, M.D., Ph.D. University of Connecticut Storrs Mansfield, CT

Project Number: RG 2826B4/1

Funding: $454,823

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“The role of NG2+ glial progenitor cells in remyelination”

Exploring immature brain cells that may be capable of maturing into adult myelin-making cells, and their role in myelin repair in MS. 


Nancy Ruddle, Ph.D. Yale University School of Medicine New Haven, CT

Project Number: RG 2394-D-5

Funding: $561,226

Term: 10/1/02 to 9/30/06

Category: Immunology

“Central nervous system inflammation & antigen presentation in MOG-inducedEAE”

Understanding immune-system activity in the brain and spinal cord during the development of MS-like disease. 


Stephen Waxman, M.D., Ph.D. Yale University School of Medicine New Haven, CT

Project Number: RG 1912D8/1

Funding: $519,249

Term: 4/1/00 to 3/31/05

Category: Neurophysiology

“Molecular pathophysiology of axons in demyelinating diseases”

Understanding mechanisms of nerve fiber destruction in MS, for clues to preventing it.

Paid in part by the Gerald J. and Dorothy R. Friedman New York Foundation for Medical Research through the NMSS New York City Chapter, in honor of Susan Thomases 


Nada Zecevic, M.D., Ph.D. University of Connecticut Health Center Farmington, CT

Project Number: RG 3083B3/1

Funding: $354,635

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Development of oligodendrocyte & microglia in the human brain: relevance forMS”

The role of specific brain cells in the development of myelin-making cells and how they impact growth and repair of nerve-insulating myelin. 


DISTRICT OF COLUMBIA
Deborah Clawson, Ph.D.
The Catholic University of America Washington, DC

Project Number: PP0960

Funding: $44,000

Term: 12/1/03 to 11/30/04

Category: Psychosocial Aspects of MS

“Prospective memory and the effect of a mnenomic strategy in multiple sclerosis”

Exploring a type of memory in people with MS, and evaluating a strategy for improving this aspect of memory. 


John Richert, M.D. Georgetown University Medical Center Washington, DC

Project Number: RG 3294-A-12

Funding: $438,976

Term: 9/30/01 to 9/30/04

Category: Immunology

“Development of small organic molecules that bind to HLA”

Designing small molecules that may be able to block the immune attack against myelin in MS. 


FLORIDA
Michael Blaber, Ph.D.
Florida State University Tallahassee, FL

Project Number: RG 3406-A-2

Funding: $342,021

Term: 4/1/03 to 3/31/06

Category: Immunology

“Regulation and structural study of a novel protease implicated indemyelination”

Studying an enzyme in the nervous system that may play an important role in myelin loss in MS. 


Todd Golde, M.D., Ph.D. Mayo Clinic Jacksonville Jacksonville, FL

Project Number: PP0943

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: CNS Repair

“Evaluation of secretase inhibitors as therapeutic agents for multiple sclerosis”

Determining the effectiveness of a compound in stimulating myelin repair. 


Lesley White, Ph.D. University of Florida Gainesville, FL

Project Number: PP0917

Funding: $44,000

Term: 5/1/03 to 4/30/04

Category: Rehabilitation

“Resistance training effects on muscle function in multiple sclerosis”

Evaluating the effects of an exercise program on improving muscle function in people with MS. 


GEORGIA
Yue Feng, M.D., Ph.D.
Emory University Atlanta, GA

Project Number: RG 3296-A-1

Funding: $400,016

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Controlling myelin basic protein expression and CNS myelination by the QKIprotein”

Investigating a specific protein to understand its function in myelin formation and its potential role in myelin repair. 


Mary Hughes, M.D. Medical College of Georgia Augusta, GA

Project Number: PP0882

Funding: $33,000

Term: 9/1/02 to 8/31/04

Category: Human Genetics

“African Americans with multiple sclerosis and apoE 4 genotyping”

Determining the role of a specific gene in the susceptibility of African Americans to MS. 


ILLINOIS
Samantha Bailey, Ph.D.
Northwestern University Chicago, IL

Project Number: FG 1563-A-1

Funding: $120,382

Term: 9/1/03 to 8/31/06

Category: Immunology

“Role of dendritic cells in the initiation and progression of central nervous systemautoimmune disease”

Determining whether cells that usually stimulate the immune attack can, in fact, neutralize this attack in an MS-like disease in mice. 


Glyn Dawson, Ph.D. University of Chicago Chicago, IL

Project Number: RG 3266A2/1

Funding: $387,713

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Role of ceramide in oligodendrocyte cell death”

Investigating a molecule that may contribute to the death of myelin-making cells in MS and testing compounds that may inhibit it. 


Cinzia Dello Russo, M.D., Ph.D. University of Illinois Chicago, IL

Project Number: FG 1515A1/1

Funding: $141,771

Term: 8/1/03 to 7/31/06

Category: Biology of Glia

“Noradrenergic regulation of microglial activation”

Analyzing complex mechanisms by which certain brain cells are activated to participate in the immune attack in an MS-like disease in rats. 


Adam Elhofy, Ph.D. Northwestern University Medical School Chicago, IL

Project Number: FG 1442-A-1

Funding: $119,725

Term: 9/1/01 to 8/31/04

Category: Immunology

“Role of monocyte chemotactic protein-1, MCP-1, in autoimmuneencephalomyelitis”

Investigating the role of certain immune molecules in decreasing the severity of MS-like disease. 


Douglas Feinstein, Ph.D. University of Illinois at Chicago Chicago, IL

Project Number: RG 3545-A-7

Funding: $360,113

Term: 4/1/04 to 3/31/07

Category: Immunology

“Therapeutic potential of PPAR delta agonists in demyelinating disease”

Determining whether a natural brain chemical can stop MS-like disease and stimulate myelin repair by replacement cells. 


Marcia Finlayson, MSc, OTR, PhD University of Illinois at Chicago Chicago, IL

Project Number: HC 0049

Funding: $379,390

Term: 7/1/02 to 6/30/05

Category: Health Care Delivery/Policy

“Aging with multiple sclerosis: unmet needs in the Great Lakes region”

Exploring the impact of aging on persons with MS, and identifying their health and quality of life needs. 


Michael Glaser, Ph.D. University of Illinois Urbana, IL

Project Number: PP0918

Funding: $44,000

Term: 3/1/03 to 2/28/05

Category: Biology of Glia

“Myelin formation in neural-glial co-cultures”

Identifying factors that may be essential for the formation of nerve-insulating myelin. 


Laurence Howard, Ph.D. Northwestern University Chicago, IL

Project Number: RG 3546-A-1

Funding: $593,965

Term: 4/1/04 to 3/31/08

Category: Immunology

“Understanding the role of gamma/delta T cells in relapsing EAE”

The potential of specific immune cells for turning off the immune attack in MS-like disease, and their promise for treating human MS. 


Byung Kim, Ph.D. Northwestern University Chicago, IL

Project Number: RG 3392A5/2

Funding: $359,241

Term: 10/1/03 to 9/30/06

Category: Immunology

“Pathogenic mechanisms of TMEV-induced demyelination”

How a mouse virus causes destruction of nerve-insulating myelin, as a possible model for how MS is triggered. 


Adam Kohm, Ph.D. Northwestern University Medical School Chicago, IL

Project Number: FG 1516-A-1

Funding: $130,947

Term: 9/1/02 to 8/31/05

Category: Immunology

“Protective mechanisms of CD30IgG3 in relapsing experimental EAE”

Studying how an experimental therapy may stop the immune attack in mice with MS-like disease, to explore its possible usefulness in treating MS. 


Guy LeBreton, Ph.D. University of Illinois at Chicago Chicago, IL

Project Number: RG 3054B2/1

Funding: $605,387

Term: 10/1/03 to 9/30/07

Category: Neuropharmacology

“Thromboxane A2 modulation of oligodendrocyte development and myelinsynthesis”

Exploring a natural molecule that may be involved in stimulating the growth and repair of nerve-insulating myelin.

Funded in part through a gift from the Dan Family through the NMSS Greater Illinois Chapter 


Stephen Miller, Ph.D. Northwestern University Chicago, IL

Project Number: RG 3489-A-6

Funding: $552,526

Term: 10/1/03 to 9/30/07

Category: Immunology

“Cellular and molecular mechanisms of CD4+CD25+ regulatory T cells in EAE”

Investigating a possible protective role for regulatory immune cells during the onset and progression of an MS-like disease. 


Stephen Miller, Ph.D. Northwestern University Chicago, IL

Project Number: RG 3289-A-5

Funding: $111,111

Term: 9/30/01 to 9/30/04

Category: Immunology

“Mechanisms of therapeutic blockade of CD154 in prevention of relapsing EAE”

Exploring ways to block the interaction of immune cells to stop ongoing immune attacks in MS-like disease, and ultimately in MS. 


Julie Olson, Ph.D. Northwestern University Chicago, IL

Project Number: FA 1517-A-1

Funding: $154,745

Term: 9/1/02 to 8/31/05

Category: Immunology

“The role of innate immune responses in a virus-induced model of multiplesclerosis”

Studying the effect that the immune response to viruses and bacteria has on the development of an MS-like disease in mice. 21 


Brian Popko, Ph.D. University of Chicago Chicago, IL

Project Number: RG 3291A4/T

Funding: $462,527

Term: 4/1/02 to 9/30/04

Category: Biology of Glia

“Global gene expression analysis of developing & perturbed oligodendrocytes”

Identifying genes that may be important to the growth and development of myelinmaking cells. 


Raymond Roos, M.D. University of Chicago Medical Center Chicago, IL

Project Number: RG 3456-A-10

Funding: $284,433

Term: 10/1/03 to 9/30/06

Category: Infectious Agents

“Theiler's virus-induced demyelinating disease”

Clarifying the mechanisms through which a virus triggers MR-like disease in mice, as a model for what might occur in MS. 


Maria Traka, Ph.D. University of Chicago Chicago, IL

Project Number: FG 1572-A-1

Funding: $130,947

Term: 8/1/03 to 7/31/06

Category: Biology of Glia

“Development of a mouse model for the inducible ablation of oligodendrocytes”

Understanding factors that promote or inhibit the repair of nerve-insulating myelin and nerve tissue, and how they might be utilized to stimulate repair in MS. 


IOWA
Minnetta Gardinier, Ph.D.
University of Iowa Iowa City, IA

Project Number: RG 2638-C-3

Funding: $393,041

Term: 4/1/02 to 3/31/05

Category: Biology of Glia

“Study of myelin/oligodendrocyte glycoprotein - human splice variants”

Exploring the functions of a protein component of nerve-insulating myelin, which may be an immune-system target in MS. 


Stanley Perlman, M.D., Ph.D. University of Iowa Hospitals and Clinics Iowa City, IA

Project Number: RG 2864-C-4

Funding: $393,971

Term: 4/1/04 to 3/31/07

Category: Infectious Agents

“Pathogenesis of MHV-induced demyelination in RAG1-/- mice”

Determining immune mechanisms involved in myelin destruction in a viral-induced model of MS, in search improved therapies for MS. 


KANSAS
Steven LeVine, Ph.D.
University of Kansas Medical Center Kansas City, KS

Project Number: RG 3188A3/1

Funding: $378,206

Term: 4/1/01 to 3/31/05

Category: Biochemistry/Biophysics

“Protective mechanisms in CNS demyelinating diseases”

Understanding natural defense mechanisms of cells that may be exploited to limit tissue damage in MS. 


Michelle McIntosh, Ph.D. University of Kansas Lawrence, KS

Project Number: PP0884

Funding: $33,000

Term: 9/1/02 to 8/31/04

Category: Immunology

“Evaluation of methotrexate-peptide conjugate in an animal model of MS”

Developing a novel method of delivering immune therapy to treat MS-like disease in mice. 


KENTUCKY
Michele Kosiewicz, Ph.D.
University of Louisville Louisville, KY

Project Number: PP0970

Funding: $44,000

Term: 1/1/04 to 12/31/04

Category: Immunology

“Characterization of tolerogenic antigen-presenting cells for use in the treatmentof EAE”

Determining the effectiveness of a type of cell for treating an MS-like disease in mice. 


Michele Kosiewicz, Ph.D. University of Louisville Louisville, KY

Project Number: RD 3410-A-1

Funding: $247,500

Term: 7/1/02 to 6/30/05

Category: Immunology

“Sex-based differences in regulatory T cell responses”

Exploring whether sex hormones alter the activity of regulatory cells that can naturally dampen destructive immune responses. 


Mengsheng Qiu, Ph.D. University of Louisville Louisville, KY

Project Number: RG 3275-A-1

Funding: $341,043

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Lineage analyses and transcription control of oligodendrocyte genesis”

Understanding the origins of myelin-making cells, and what factors are involved in their growth and development. 


Deming Sun, M.D. University of Louisville Louisville, KY

Project Number: RG 3413A4/1

Funding: $323,139

Term: 10/1/03 to 9/30/06

Category: Immunology

“Progression of autoimmune encephalomyelitis”

Examining a subset of immune cells that seem to contribute to a severe, progressive course of MS-like disease in mice. 


Jill Suttles, Ph.D. University of Louisville Louisville, KY

Project Number: RG 3374-A-1

Funding: $373,804

Term: 10/1/02 to 9/30/05

Category: Biochemistry/Biophysics

“Role of fatty acid binding proteins in the pathogenesis of EAE”

How a molecule that allows fatty acids to function may play a role in the immune attack in MS and MSlike disease and how it might be blocked. 


MARYLAND
Jeff Bulte, Ph.D.
The Johns Hopkins University Baltimore, MD

Project Number: PP0922

Funding: $44,000

Term: 6/1/03 to 5/31/04

Category: CNS Repair

“MR tracking of magnetically labeled stem cells in a mouse EAE model”

Testing a novel method of tracing the fate of stem cells introduced into mice with MS-like disease, to determine whether they reach sites needing tissue repair.

Funded in full by donors to the National MS Society's Maryland Chapter 


Peter Calabresi, M.D. The Johns Hopkins Hospital Baltimore, MD

Project Number: CA 1029-A-2

Funding: $825,000

Term: 4/1/04 to 3/31/09

Category: Neuropathology

“Collaborative MS Research Center Award”

An interdisciplinary effort to define how nerve fibers are damaged in MS and to search for ways to protect them. 


Susan Courtney-Faruqee, Ph.D. Johns Hopkins University Baltimore, MD

Project Number: PP0937

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: Psychosocial Aspects of MS

“FMRI investigation of the neural basis of cognitive fatigue in MS”

Studying cognitive fatigue in people with MS using a novel imaging technique. 


Roy Mariuzza, Ph.D. University of Maryland Biotech Institute Rockville, MD

Project Number: RG 2747-C-3

Funding: $707,740

Term: 9/30/01 to 9/30/06

Category: Immunology

“Structural basis of molecular mimicry in multiple sclerosis”

Determining the three-dimensional structure of molecules involved in the immune attack against nervous-system tissue in MS.


William Regenold, M.D. University of Maryland Baltimore, MD

Project Number: PP0932

Funding: $44,000

Term: 7/1/03 to 6/30/04

Category: Measuring MS Disease Activity

“Polyol metabolism and disease progression in multiple sclerosis”

Taking a new approach to understanding the mechanism of nerve fiber damage in progressive MS.


David Scott, Ph.D. American Red Cross/Holland Lab Derwood, MD

Project Number: RG 3277A1/1

Funding: $82,500

Term: 10/1/02 to 9/30/05

Category: Immunology

“Gene therapy for tolerance induction in EAE as a model for MS”

“Infecting” immune cells with viruses genetically engineered to deliver myelin proteins, in an attempt to halt the immune attack in MS-like disease. 


Janet Sutton, MSPH, PhD People to People Health Foundation-Project Hope Bethesda, MD

Project Number: HC 0060

Funding: $296,897

Term: 7/1/03 to 6/30/05

Category: Health Care Delivery/Policy

“Understanding the health care experiences of minority populations with MS”

Conducting a survey to determine whether the health care experiences of African Americans and Hispanics with MS are different from that of Caucasians with MS. 


Biying Xu, M.D., Ph.D. American Red Cross/Holland Lab Derwood, MD

Project Number: FA 1485-A-2

Funding: $149,265

Term: 8/1/02 to 7/31/05

Category: Immunology

“Gene therapy for tolerance to encephalitogenic proteins”

Testing the effectiveness of gene therapy -- a novel therapeutic approach -- in an MS-like disease in mice. 


MASSACHUSETTS
Sara Abromson-Leeman, Ph.D.
Harvard Medical School Boston, MA

Project Number: RG 3310A3/1TT

Funding: $219,847

Term: 7/1/03 to 3/31/05

Category: Immunology

“EAE: T cell phenotype determines site and mechanism of disease”

Understanding why certain immune cells attack particular areas of the brain and spinal cord in MS-like disease, and how they cause different symptoms. 


Heather Arnett, Ph.D. Dana Farber Cancer Institute Boston, MA

Project Number: FG 1522-A-1

Funding: $130,947

Term: 8/1/03 to 8/31/06

Category: Biology of Glia

“Regulation of Olig2 in oligodendrocyte fate determination”

Identifying proteins that promote the formation of myelin-making cells, for clues to stimulating myelin repair in MS. 


Alberto Ascherio, MD, DrPH Harvard School of Public Health Boston, MA

Project Number: PP0925

Funding: $44,000

Term: 6/1/03 to 5/31/04

Category: Epidemiology

“Prospective study of vitamin D and multiple sclerosis”

Investigating whether higher blood levels of vitamin D reduces the risk of developing MS in a population study.

Paid in full by funds raised by the QVC Cure by the Shore in collaboration with the NMSS Southern California Chapter 


Steven Brass, M.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1566-A-1

Funding: $162,160

Term: 8/1/03 to 7/31/06

Category: Immunology

“Chemokine receptor expression and immune regulation in multiple sclerosis”

Investigating the role of immune messenger proteins and the molecules with which they interact in the development of multiple sclerosis. 


Lisa Bregoli, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FA 1579-A-1

Funding: $154,745

Term: 8/1/03 to 7/31/06

Category: Immunology

“Antigen specificity of CD8 T cells in multiple sclerosis plaques”

Examining the specific targets on nerve-insulating myelin which immune cells react against in areas of myelin damage in people with MS. 


Guifang Cai, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1453-A-1

Funding: $120,725

Term: 7/1/01 to 6/30/04

Category: Immunology

“Immunoregulatory role of a suppressive costimulatory molecule, PD-1, in MS”

Determining whether a molecule that can normally suppress certain immune attacks is abnormal in people with MS. 


Jill Cameron, Ph.D. Beth Israel Deaconess Medical Center Boston, MA

Project Number: FG 1511-A-1

Funding: $130,947

Term: 9/1/02 to 8/31/05

Category: Biology of Glia

“The role of integrins in myelination”

Studying molecular signals that influence the production of nerve-insulating myelin, for clues to ways to stimulate myelin repair in MS. 


Sumone Chakravarti, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1478-A-1

Funding: $120,382

Term: 8/1/02 to 7/31/05

Category: Immunology

“Effect of polymorphic forms of a Th1-specific molecule, TIM-3, on EAE”

Exploring a molecule on aggressive immune cells which may be a potential target for developing therapies to stop the immune attack in MS. 


Alexandra Degenhardt, M.D. Beth Israel Deaconess Medical Center Boston, MA

Project Number: FP 1532-A-1

Funding: $11,710

Term: 8/1/03 to 7/31/05

Category: Therapy/Management of MS

“Sylvia Lawry Physician Fellowship”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


Martin Dorf, Ph.D. Harvard Medical School Boston, MA

Project Number: RG 2989B3/1

Funding: $390,691

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Mechanisms of chemokine-mediated astrocyte activation”

Investigating how immune messenger chemicals interact with specific brain cells during the immune attack in MS. 


Susan Gauthier, D.O. Brigham and Women's Hospital Boston, MA

Project Number: FP 1506-A-1

Funding: $120,000

Term: 8/1/02 to 7/31/05

Category: Therapy/Management of MS

“Sylvia Lawry Physician Fellowship”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


David Hafler, M.D. Brigham and Women's Hospital Boston, MA

Project Number: CA 1001-A-14

Funding: $825,000

Term: 4/1/03 to 3/31/08

Category: Human Genetics

“Palmer Collaborative MS Research Center Award: MS Targeted HaplotypeProject”

A multi-disciplinary effort to take the next big step to finding MS genes and correlate them with clinical findings, to find the cause of MS.

Funded in full by a gift from Barbara Palmer to the NMSS Central New England Chapter 


David Hafler, M.D. Brigham and Women's Hospital Boston, MA

Project Number: RG 3308A10/1

Funding: $370,865

Term: 4/1/02 to 3/31/05

Category: Immunology

“Regulatory T cells in multiple sclerosis”

Examining immune cells that appear to be crucial to stopping immune attacks against the body's own tissues, and their possible failure in MS. 


David Hafler, M.D. Whitehead Institute for Biomedical Research Cambridge, MA

Project Number: RG 3417A12/2

Funding: $670,788

Term: 4/1/04 to 3/31/07

Category: Human Genetics

“A whole genome admixture scan for the multiple sclerosis genes”

Scanning for MS genes in genetic material from patients whose ancestry contain a mix of populations at high risk and at low risk for MS. 


Miguel Hernan, MD, DrPH Harvard School of Public Health Boston, MA

Project Number: RG 3236A1/1

Funding: $325,358

Term: 9/30/01 to 9/30/04

Category: Epidemiology

“Risk factors and incidence of MS in a population-based follow-up study”

Asking whether studying medical data on a large group of people over time can reveal possible risk factors contributing to the development of MS. 


Samia Khoury, M.D. Brigham and Women's Hospital Boston, MA

Project Number: RG 3504-A-8

Funding: $237,916

Term: 10/1/03 to 9/30/07

Category: Immunology

“Role of PD1-PDL pathway in EAE”

Understanding the interaction of molecules on immune cells which may help stimulate recovery from an MS-like disease in mice. 


Samia Khoury, M.D. Brigham and Women's Hospital Boston, MA

Project Number: RG 2988B6/2

Funding: $521,492

Term: 4/1/02 to 3/31/05

Category: Immunology

“Mechanisms of immune regulation in chronic EAE”

Investigating the presence and function of specific immune cells that may be responsible for preventing or stopping the immune attack in MS-like disease. 


Cherry Kingsley, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1575-A-1

Funding: $121,982

Term: 8/1/03 to 7/31/06

Category: Immunology

“Role of costimulation in CD25+CD4+ regulatory T cell function in EAE”

Developing a mouse model to study the role of specific immune cells in regulating the immune attack in MS-like disease. 


Vijay Kuchroo, Ph.D., D.V.M. Brigham and Women's Hospital Boston, MA

Project Number: RG 2571-D-9

Funding: $414,048

Term: 4/1/03 to 3/31/06

Category: Immunology

“Pathogenic & regulatory mechanisms in EAE”

Identifying factors that control immune T cells that recognize and can attack myelin in MS-like disease. 


Matthew Meyerson, M.D., Ph.D. Dana-Farber Cancer Institute Boston, MA

Project Number: PP0955

Funding: $44,000

Term: 9/30/03 to 9/30/04

Category: Infectious Agents

“Pathogen discovery by computational subtraction in multiple sclerosis”

Investigating a possible role for infectious agents in MS using novel technology. 


Sarah Minden, M.D. Abt Associates Inc. Cambridge, MA

Project Number: HC 0032

Funding: $3,287,078

Term: 4/1/99 to 12/31/06

Category: Health Care Delivery/Policy

“The Sonya Slifka longitudinal multiple sclerosis study”

Establishing a researchoriented repository of in-depth information about a nationwide group of people with MS over time.

The Sonya Slifka longitudinal multiple sclerosis study 


Gregory Pope, M.S. RTI International Waltham, MA

Project Number: HC 0053

Funding: $493,059

Term: 7/1/02 to 6/30/05

Category: Health Care Delivery/Policy

“Quality of health care in multiple sclerosis”

Analyzing standard and recommended health care practices in persons with MS to establish a basis for improving standards of care. 


Jayagopala Reddy, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FA 1449-A-1

Funding: $129,566

Term: 7/1/01 to 6/30/04

Category: Immunology

“Analysis of endogenous myelin proteolipid protein-reactive T cell repertoire”

Exploring aspects of immune responses that might account for why the immune system attacks the body's own tissues in people with MS. 


David Rintell, Ed.D. Brigham and Women's Hospital Boston, MA

Project Number: HC 0059

Funding: $485,899

Term: 7/1/03 to 6/30/06

Category: Health Care Delivery/Policy

“Quality of mental health care in multiple sclerosis”

Identifying aspects of mental health care and treatment in MS to maximize its quality and usefulness. 


David Rowitch, M.D., Ph.D. Dana-Farber Cancer Institute Boston, MA

Project Number: JF 2100-A-1

Funding: $530,452

Term: 7/1/00 to 6/30/05

Category: Biology of Glia

“Oligodendrocyte lineage gene function in the central nervous system”

Studying genes that determine the development and function of myelin-making cells.

Funded in part by a gift from Joan and Virgil Stiefel Simon through the NMSS Colorado Chapter 


Arlene Sharpe, M.D., Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: RG 2779-C-4

Funding: $431,024

Term: 4/1/03 to 3/31/07

Category: Immunology

“Manipulation of the B7-CD28/CTLA-4 costimulatory pathway & EAE”

Attempting to block immune activity in MS-like disease in search of better treatment for human MS.

Funded in part by the Estate of Norman Cohn 


Charles Stiles, Ph.D. Dana Farber Cancer Institute Boston, MA

Project Number: CA 1022-A-1

Funding: $825,000

Term: 4/1/03 to 3/31/08

Category: CNS Repair

“Collaborative MS Research Center Award”

Joining forces to develop strategies for tissue repair and identify new therapeutic targets in MS.

Funded in full by the NMSS New York City Chapter


Tao Sun, Ph.D. Beth Israel Deaconess Medical Center Boston, MA

Project Number: FA 1433A1/T

Funding: $74,034

Term: 10/1/02 to 6/30/04

Category: Biology of Glia

“Interactions of oligodendrocyte precursors and neurons in the PDFR alphamutant brain”

Examining the role of a specific protein in the formation of myelinmaking cells, for clues to stimulating myelin repair in MS. 


Richard Van Emmerik, Ph.D. University of Massachusetts Amherst, MA

Project Number: PP0934

Funding: $44,000

Term: 7/1/03 to 6/30/04

Category: Rehabilitation

“Postural stability and fatigue in multiple sclerosis”

Determining the factors that contribute to balance control problems in people with MS. 


Timothy Vartanian, M.D., Ph.D. Beth Israel Deaconess Medical Center Boston, MA

Project Number: RG 3426A2/1

Funding: $473,801

Term: 10/1/03 to 9/30/06

Category: Immunology

“The function of toll-like receptors & innate immunity in oligodendrocyte injury”

Determining how the interaction between infectious agents and the immune system may contribute to myelin and nerve fiber damage in MS. 


Yijun Xu, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1479A1/1

Funding: $141,771

Term: 8/1/03 to 7/31/06

Category: Immunology

“Regulatory effect of lymphocyte-driven TGF in autoimmune encephalomyelitis”

Understanding the role of an immune messenger protein that may regulate MS-like disease in mice, for clues to better treatments for MS. 


Bing Zhu, Ph.D. Brigham and Women's Hospital Boston, MA

Project Number: FG 1569-A-1

Funding: $120,382

Term: 8/1/03 to 7/31/06

Category: Immunology

“The role of CD8+ T regulatory cells in EAE”

Defining the mechanisms by which a subset of immune cells may regulate the immune attack in MS-like disease in mice. 


MICHIGAN
James Garbern, M.D., Ph.D.
Wayne State University Detroit, MI

Project Number: RG 3204A1/1

Funding: $433,728

Term: 9/30/01 to 9/30/04

Category: Neuropathology

“Models of axonal injury due to myelin disorders”

Exploring the pathology that underlies the release of a brain chemical which is currently used to measure nerve cell damage in MS. 


Alexander Gow, Ph.D. Wayne State University Detroit, MI

Project Number: RG 2891-C-4

Funding: $480,213

Term: 10/1/03 to 9/30/06

Category: Biology of Glia

“Molecular mechanisms of stress induced oligodendrocyte cell death”

Clarifying factors that may contribute to the death of cells that make nerve-insulating myelin, to develop strategies to offset this damage in MS. 


Lori Isom, Ph.D. University of Michigan Ann Arbor, MI

Project Number: RG 2882C4/1

Funding: $566,257

Term: 4/1/04 to 3/31/07

Category: Neurophysiology

“Molecular control of sodium channel density and localization in myelinatedaxons”

Investigating how protein pores in nerve fibers become properly clustered to allow for normal nerve signal conduction. 


Lori Isom, Ph.D. University of Michigan Ann Arbor, MI

Project Number: RG 2882-B-3

Funding: $546,784

Term: 9/30/00 to 9/30/04

Category: Neurophysiology

“Molecular control of sodium channel density and localization in myelinatedaxons”

Understanding how protein pores in nerve fibers are regulated to allow for proper nerve signal conduction. 


John Kamholz, M.D., Ph.D. Wayne State University Detroit, MI

Project Number: RG 2769-C-6

Funding: $413,477

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“The role of homeodomain protein, Gtx, in oligodendrocyte differentiation”

Investigating the role of a newly identified protein in the formation of myelin, the nerve-fiber coating destroyed by MS. 


Jeffrey Loeb, M.D., Ph.D. Wayne State University Detroit, MI

Project Number: RG 3410-A-2

Funding: $385,367

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Axoglial communication through regulated release of neuregulin”

Understanding the communication and mutual support between nerve fibers and myelin-making cells that maintain the function and structure of both. 


Howard Petty, Ph.D. University of Michigan Ann Arbor, MI

Project Number: RD 3409A1/T

Funding: $491,246

Term: 1/1/03 to 6/30/06

Category: Immunology

“Mechanisms regulating neutrophil activation in pregnancy”

Tracking specific immune cells during pregnancy, to improve understanding of factors that may be capable of turning off inflammation such as that involved in MS. 


Robert Skoff, Ph.D. Wayne State University Detroit, MI

Project Number: RG 3449-A-6

Funding: $469,087

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Mammalian oligodendrocytes are sexually dimorphic”

Examining biologic differences in myelin-making cells between male and female mice with an MS-like disease, and implications for human MS. 


Dusanka Skundric, M.D., Ph.D. Wayne State University Detroit, MI

Project Number: PP0958

Funding: $44,000

Term: 11/1/03 to 10/31/04

Category: Immunology

“Molecular mechanisms of oligodendrocyte damage by MOG specific T cells”

Determining the immune mechanisms of action in two types of MS-like disease in mice. 


David Stevens, Ph.D. Wayne State University Detroit, MI

Project Number: PP0926

Funding: $44,000

Term: 1/1/04 to 12/31/04

Category: Immunology

“Low cell-dose transfer of suppression in EAE”

Investigating a novel method of treating an MS-like disease in mice. 


Robert Swanborg, Ph.D. Wayne State University Detroit, MI

Project Number: RG 1073H11/1

Funding: $283,840

Term: 9/30/99 to 9/30/04

Category: Immunology

“Regulation of autoimmune encephalomyelitis”

How the activation of myelindestructive immune cells is controlled in MS-like disease. 


Harley Tse, Ph.D. Wayne State University Detroit, MI

Project Number: RG 3288A6/1

Funding: $405,623

Term: 4/1/02 to 3/31/05

Category: Immunology

“CD1-restricted regulation of murine adoptive EAE”

Attempting to prove that a specific type of immune cell plays a crucial role in the onset of MS-like disease in mice, and by implication, in human MS. 


Aliya Zaidi, Ph.D. Wayne State University Detroit, MI

Project Number: FA 1503-A-1

Funding: $101,653

Term: 8/1/02 to 7/31/04

Category: Biology of Glia

“Oxidative-stress induced death pathways in oligodendrocytes”

Studying biological mechanisms that may lead to the death of myelin-making cells in MS. 


MINNESOTA
Allan Bieber, Ph.D.
Mayo Clinic and Foundation Rochester, MN

Project Number: RG 3481-A-1

Funding: $280,273

Term: 10/1/03 to 9/30/05

Category: CNS Repair

“Genetic analysis of spontaneous remyelination”

Studying mechanisms that lead to spontaneous myelin repair and restoration of neurologic function in a rodent model of MS-like disease.

Funded in part through a gift from the Dan Family through the NMSS Greater Illinois Chapter 


Meenakshi Khare, Ph.D. Mayo Clinic and Foundation Rochester, MN

Project Number: FA 1578-A-1

Funding: $161,560

Term: 8/1/03 to 7/31/06

Category: Immunology

“Disease pathogenesis of MOG-induced EAE in HLA class II transgenic mice”

Understanding the role of genes that control immune responses in the development of MS, to find ways to stop the immune attack. 


Claudia Lucchinetti, M.D. Mayo Clinic and Foundation Rochester, MN

Project Number: RG 3185-A-2

Funding: $1,851,117

Term: 4/1/00 to 3/31/05

Category: Neuropathology

“Clinico-pathological correlates of the MS lesion”

Studying MS lesions (damaged areas) in individuals with MS for clues to different patterns of destructive immune factors and correlating findings with clinical manifestations. 


Virgil Mathiowetz, Ph.D. University of Minnesota Minneapolis, MN

Project Number: RG 3255A1/1

Funding: $268,048

Term: 9/30/01 to 9/30/04

Category: Rehabilitation

“Effects of an energy conservation course for persons with multiple sclerosis”

Can strategies to save energy and ward off fatigue improve quality of life in MS? 


Moses Rodriguez, M.D. Mayo Clinic and Foundation Rochester, MN

Project Number: CA 1011A8/1

Funding: $825,000

Term: 4/1/04 to 3/31/09

Category: CNS Repair

“Collaborative MS Research Center Award”

Screening small molecules for their potential to help define functions of myelin-making cells, and their potential to stimulate myelin repair in MS. 


Isobel Scarisbrick, Ph.D. Mayo Clinic Foundation Rochester, MN

Project Number: PP0964

Funding: $44,000

Term: 12/1/03 to 11/30/04

Category: Neuropathology

“Kallikrein 6 mRNA splice variants as targets to treat CNS demyelinatingdisease”

Investigating possible targets for therapies that treat inflammation and tissue damage in an MS-like disease in mice. 


Isobel Scarisbrick, Ph.D. Mayo Clinic Foundation Rochester, MN

Project Number: RG 3367-A-2

Funding: $395,838

Term: 10/1/02 to 9/30/05

Category: Neuropathology

“Mechanisms of myelencephalon specific protease-mediated proteolysis indemyelination”

The role of a protein-destroying enzyme in the destruction of nerveinsulating myelin in MS-like disease, and possible ways to block its activity. 


Brian Weinshenker, M.D. Mayo Clinic and Foundation Rochester, MN

Project Number: RD 3406-A-6

Funding: $749,820

Term: 9/1/02 to 8/31/05

Category: Human Genetics

“Interferon gamma polymorphisms and gender bias in MS”

Studying genetic variations related to an interferon and their possible connection to gender differences in susceptiblity to MS.

Funded in part by a gift from the Thomas Maren Foundation 


MISSOURI
Anne Cross, M.D.
Washington University Saint Louis, MO

Project Number: CA 1012-A-13

Funding: $825,000

Term: 4/1/03 to 3/31/08

Category: Measuring MS Disease Activity

“Collaborative MS Research Center Award”

A major effort to apply new magnetic resonance technology to tracking brain tissue damage and recovery in MS. 


Anne Cross, M.D. Washington University Saint Louis, MO

Project Number: RG 3292A9/1

Funding: $627,832

Term: 4/1/02 to 3/31/05

Category: Therapy/Management of MS

“A phase II trial of Rituxan in multiple sclerosis”

A clinical trial of an immunebased therapy for treatment of relapsing-remitting MS. 


Anne Cross, M.D. Washington University Saint Louis, MO

Project Number: RG 3085A8/1T

Funding: $100,471

Term: 10/1/01 to 9/30/04

Category: Therapy/Management of MS

“Precipitation of MS exacerbations by urinary tract infections”

Determining whether urinary tract infections trigger flare-ups of MS, and the impact of preventing such infections.

Funded in part by a gift from the NMSS Ohio Valley Chapter 


Robyn Klein, M.D., Ph.D. Washington University Saint Louis, MO

Project Number: RG 3450A1/2

Funding: $523,529

Term: 4/1/04 to 3/31/07

Category: Immunology

“Chemokines & lymphocyte trafficking in the pathogenesis of experimentalautoimmune encephalomyelitis”

Exploring chemical factors that attract destructive immune forces into the brain in MS-like disease, for clues to stopping their entry to treat MS. 


John Russell, Ph.D. Washington University Saint Louis, MO

Project Number: RG 3314-A-3

Funding: $248,076

Term: 9/30/01 to 9/30/04

Category: Immunology

“Tumor necrosis factor receptor family molecules and EAE pathogenesis”

Examining immune molecules in MS-like disease that may be involved in the death of myelin-making cells in MS. 


Sheng-Kwei Song, Ph.D. Washington University Saint Louis, MO

Project Number: RG 3376A2/1

Funding: $496,973

Term: 4/1/03 to 3/31/06

Category: Neuropathology

“In vivo characterization of white matter injury in the central nervous system”

Evaluating the potential of a novel imaging technology to diagnose and evaluate demyelinating disease. 


NEBRASKA
Kristen Drescher, Ph.D.
Creighton University Omaha, NE

Project Number: RG 3379A2/1

Funding: $489,489

Term: 4/1/03 to 3/31/06

Category: Immunology

“Inhibiting demyelination by immunization using coxsackievirus vectors”

Attempting to derail the immune attack in MS-like disease using a unique vaccination strategy. 


Kalipada Pahan, Ph.D. University of Nebraska Medical Center Lincoln, NE

Project Number: RG 3422A1/1

Funding: $273,946

Term: 10/1/03 to 9/30/06

Category: Immunology

“Gemfibrozil & EAE”

Testing the effectiveness of a cholesterol-lowering agent in suppressing disease activity and the immune attack in an MS-like disease in mice. 


Thomas Petro, Ph.D. University of Nebraska Medical Center Lincoln, NE

Project Number: RG 3381-A-2

Funding: $209,708

Term: 10/1/02 to 9/30/05

Category: Immunology

“Role of IL-12 gene expression in virus-induced encephalomyelitis”

Exploring the function of a gene that controls an immune-system messenger chemical and its possible activity in MS-like disease. 


NEW HAMPSHIRE
Toni Bauman, M.D.
Dartmouth Medical School Lebanon, NH

Project Number: FP 1443-A-1

Funding: $120,000

Term: 1/1/02 to 12/31/04

Category: Psychosocial Aspects of MS

“Mood dysfunction in MS: immunologic correlation and immunotherapy”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


John Randolph, Ph.D. Dartmouth Medical School Lebanon, NH

Project Number: FG 1510-A-1

Funding: $93,344

Term: 8/1/02 to 7/31/04

Category: Psychosocial Aspects of MS

“Functional and structural neuroimaging of executive functions in multiplesclerosis”

Using advanced brain imaging to examine physiological processes during thinking and planning tasks to understand cognitive problems in MS. 


Heather Wishart, Ph.D. Dartmouth Medical School Lebanon, NH

Project Number: RG 3248-A-1

Funding: $279,454

Term: 4/1/01 to 3/31/05

Category: Measuring MS Disease Activity

“Brain activation in MS: an fMRI study of working memory and motorfunctions”

Using a novel brain imaging method to observe brain activity during memory and movement tasks in MS. 


NEW JERSEY 
Patrizia Casaccia-Bonnefil, M.D., Ph.D. UMDNJ-Robert Wood Johnson Medical School Piscataway, NJ

Project Number: RG 3421-A-4

Funding: $184,067

Term: 4/1/03 to 3/31/06

Category: CNS Repair

“Understanding the molecular basis of remyelination failure”

Identifying molecular mechanisms that may be responsible for incomplete myelin repair in MS. 


Nancy Chiaravalloti, Ph.D. Kessler Medical Rehabilitation Res. & Educ. Corp. West Orange, NJ

Project Number: RG 3330A1/3

Funding: $428,372

Term: 4/1/04 to 3/31/07

Category: Rehabilitation

“Working memory in MS: Using fMRI to identify the deficit”

Correlating memory difficulties with brain activity to understand how to overcome such difficulties in MS. 


John DeLuca, Ph.D. ABPP Kessler Medical Rehabilitation Res. & Educ. Corp. West Orange, NJ

Project Number: RG 2596B2/2

Funding: $285,154

Term: 9/30/00 to 9/30/04

Category: Psychosocial Aspects of MS

“Relating cognitive dysfunction and functional status in multiple sclerosis”

Assessing how cognitive problems experienced by people with MS affect their social, family and work lives.

Funded in part by a gift from the NMSS Gateway Area Chapter 


Suhayl Dhib-Jalbut, M.D. UMDNJ-New Jersey Medical School New Brunswick, NJ

Project Number: RG 3281A2/T

Funding: $359,002

Term: 10/1/03 to 9/30/05

Category: Immunology

“Interferon-beta gene therapy in an animal model of MS”

Testing a novel method of delivering interferon-beta into the brain in a mouse model of MS. 


Martin Grumet, Ph.D. Rutgers University Piscataway, NJ

Project Number: RG 3503-A-2

Funding: $541,222

Term: 10/1/03 to 9/30/07

Category: Biology of Glia

“Roles of neurofascin in nerve development and function”

Studying the role of a protein in the formation of myelin and in the development of nerve fibers, to add data needed for stimulating tissue repair in MS. 


Robert Ledeen, Ph.D. University of Medicine and Dentistry of New Jersey Newark, NJ

Project Number: RG 3256A5/1

Funding: $297,902

Term: 9/30/01 to 9/30/04

Category: Biochemistry/Biophysics

“N-acetylaspartate in myelin formation and demyelination”

Determining the role of a brain chemical used by researchers to measure damage to nerve cells in MS. 


Mireya Marin-Husstege, Ph.D. UMDNJ-Robert Wood Johnson Medical School Piscataway, NJ

Project Number: FA 1512-A-1

Funding: $166,226

Term: 8/1/02 to 7/31/05

Category: Biology of Glia

“Regulation of myelin components by histone deacetylation”

Understanding a mechanism that may enable the formation of nerve-insulating myelin, ultimately for clues to repairing myelin damaged in MS. 


Andrew Pachner, M.D. UMDNJ-New Jersey Medical School Newark, NJ

Project Number: RG 3402A3/1

Funding: $279,844

Term: 4/1/03 to 3/31/06

Category: Therapy/Management of MS

“Effect of anti-interferon antibodies on interferon bioavailability in people withmultiple sclerosis”

Determining whether immune antibodies impede the effectiveness of treating MS with interferon beta. 


Maria Schultheis, Ph.D. Kessler Medical Rehabilitation Res. & Educ. Corp. West Orange, NJ

Project Number: RG 3353A1/1

Funding: $357,840

Term: 10/1/02 to 9/30/05

Category: Rehabilitation

“Examining the demands of driving in multiple sclerosis”

Understanding aspects of MS that may interfere with driving abilities, for clues to addressing this quality of life issue. 


Emilia Vitale, Ph.D. UMDNJ-New Jersey Medical School Newark, NJ

Project Number: RG 3301A1/1

Funding: $419,795

Term: 4/1/02 to 3/31/05

Category: Human Genetics

“Identification of MS susceptibility genes on the 12p12 chromosome region”

Homing in on genes on chromosomes that may help confer susceptibility to MS. 


NEW MEXICO
Oscar Bizzozero, Ph.D.
University of New Mexico Albuquerque, NM

Project Number: PP0938

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: Biology of Glia

“Myelin PLP-mediated transport of ions and small molecules across lipidmembranes”

Examining the role of a major protein in nerve-insulating myelin. 


NEW YORK
Pamela Block, Ph.D.
State University of New York at Stony Brook Stony Brook, NY

Project Number: PP0950

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: Psychosocial Aspects of MS

“Assessing attitudinal & structural barriers to physical & recreational activity”

Determining factors that facilitate or discourage physical and recreational activity among people with MS who use wheelchairs and walkers. 


Terry DiLorenzo, Ph.D. Yeshiva University New York, NY

Project Number: PP0845

Funding: $33,000

Term: 2/1/02 to 1/31/05

Category: Psychosocial Aspects of MS

“Older individuals with multiple sclerosis: factors related to adjustment”

Investigating the impact of aging on quality of life in individuals with MS. 


Marie Filbin, Ph.D. Hunter College New York, NY

Project Number: RG 2760C4/1

Funding: $601,392

Term: 4/1/03 to 3/31/07

Category: CNS Repair

“Blocking the inhibition of axonal regeneration by MAG/myelin”

Reversing the action of a protein that prohibits the regeneration of damaged nerve fibers, to find ways to re-grow nerve fibers that are lost in MS.

Funded in part by a gift from the Manhattan Society of NMSS New York City chapter 


Glaucia Furtado, Ph.D. Mount Sinai Medical Center New York, NY

Project Number: RG 3479-A-2

Funding: $461,525

Term: 10/1/03 to 9/30/06

Category: Immunology

“Initial activation of encephalomyelitogenic T cells in EAE”

Studying whether inhibiting multiple immune messenger proteins can block their ability to help immune cells move into the brain and launch an attack in an MS-like disease model.

Funded in part by a gift from the NMSS New York City chapter 


Steven Goldman, M.D., Ph.D. (TRANSFER PENDING) Cornell University Medical College New York, NY

Project Number: RG 2898-B-2

Funding: $495,990

Term: 9/30/00 to (To Be Determined)

Category: CNS Repair

“Therapeutic remyelination using human neural and white matter progenitorcells”

Attempting to repair myelin damage by transplanting new myelin-making cells in MS-like disease.

Funded in full by gifts from the Barancik Foundation and the Alan Buegeleisen Research Fund 


Maria Matilde Inglese, M.D. New York University New York, NY

Project Number: FA 1547-A-1

Funding: $105,318

Term: 8/1/03 to 9/30/05

Category: Diagnostic Methods

“Novel MR spectroscopic markers of primary progressive multiple sclerosisactivity”

Using novel technology to determine whether tracking levels of certain brain chemicals can help to monitor disease activity in people with primary-progressive MS.

Funded by the NMSS New York City Chapter through the Martin S. Davis Research Fellowship Endowment 


Bernadette Kalman, M.D., Ph.D. St. Luke's-Roosevelt Hospital New York, NY

Project Number: RG 3521-A-6

Funding: $632,251

Term: 4/1/04 to 3/31/06

Category: Human Genetics

“Variants of beta-chemokines within chromosome 17q11 in MS”

Searching for possible gene variations in a specific chromosome region that may account for increased susceptibility to MS. 


Bernadette Kalman, M.D., Ph.D. St. Luke's-Roosevelt Hospital New York, NY

Project Number: RG 3334A4/T

Funding: $405,594

Term: 10/1/02 to 9/30/05

Category: Human Genetics

“Nuclear and mitochondrial candidate genes in MS”

Identifying genes that contribute to susceptibility to disability in people with MS.

Funded in part through a gift from the Manhattan Society of the NMSS New York City Chapter 


Lauren Krupp, M.D. State University of New York at Stony Brook Stony Brook, NY

Project Number: RG 3315A4/1

Funding: $784,201

Term: 4/1/02 to 3/31/07

Category: Psychosocial Aspects of MS

“A longitudinal study of mild cognitive impairment in multiple sclerosis”

Following a group of individuals with MS who have mild cognitive problems to evaluate whether this symptom becomes worse over time. 


Juan Lafaille, Ph.D. New York University Medical Center New York, NY

Project Number: RG 3361-A-2

Funding: $389,390

Term: 4/1/02 to 3/31/05

Category: Immunology

“Sequence of events leading to the development and regulation of spontaneousEAE”

Assessing the role of lymph nodes in the development of an MS-like disease in mice. 


Jorge Larocca, Ph.D. Albert Einstein College of Medicine Bronx, NY

Project Number: RG 1941-E-5

Funding: $652,168

Term: 9/30/00 to 9/30/04

Category: Biology of Glia

“Role of GTP-binding proteins in the regulation of myelin biogenesis”

Tagging and tracking a protein in myelin-making cells to determine its function and role in the production of nerve-insulating myelin. 


Yong Liu, M.D., Ph.D. NYS Institute for Basic Research in Devp.Disab. Staten Island, NY

Project Number: PP0931

Funding: $33,000

Term: 7/1/03 to 10/31/04

Category: Biology of Glia

“Taurine chloramine and inflammatory mediator induced damage ofoligodendrocytes”

Investigating whether a molecule that protects against inflammation can protect myelin-making cells during an immune attack on the brain. 


Fred Lublin, M.D. Mount Sinai Medical Center New York, NY

Project Number: RG 3363A8/1

Funding: $759,654

Term: 10/1/02 to 9/30/05

Category: Therapy/Management of MS

“Oral megadose corticosteroid therapy of acute exacerbations in MS (OMEGA)”

Conducting a multi-center clinical trial to compare the effectiveness of oral versus intravenous steroids to speed recovery from acute attacks of MS.

Funded in part by a gift from the NMSS New York City Chapter 


Jeffrey Mason, Ph.D. (TRANSFER PENDING) Columbia Presbyterian Medical Center New York, NY

Project Number: TA 3004A2

Funding: $559,189

Term: 8/1/03 to 7/31/08

Category: CNS Repair

“The ability of IGF-1 to inhibit the formation of chronic demeylinated lesions”

Identifying the mechanisms responsible for the destruction of myelin-making cells and nerve fibers in MS, and determining whether a natural growth factor can prevent this damage. 


Paul Massa, Ph.D. SUNY Upstate Medical University Syracuse, NY

Project Number: RG 2569-C-5

Funding: $509,562

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Function of SHP-1 in oligodendroglia”

Exploring interactions between a component of myelin-making cells and an immune chemical that may play a role in both inflammation and myelin repair in MS. 


Timothy Mosmann, Ph.D. University of Rochester Rochester, NY

Project Number: RD 3408-A-1

Funding: $550,000

Term: 7/1/02 to 6/30/06

Category: Immunology

“Bi-directional interactions between immunity and pregnancy”

How the immune system is inhibited during pregnancy to allow the mother to carry a “foreign” fetus, and how this mechanism may be applied to treating autoimmune disease. 


Richard O'Connor, Ph.D Trudeau Institute Saranac Lake, NY

Project Number: FG 1513-A-1

Funding: $131,854

Term: 8/1/02 to 7/31/05

Category: Immunology

“The mechanisms of adjuvant immunotherapy in EAE”

How does innoculation with an infectious agent protect mice against MS-like disease, and how can this phenomenon by applied against MS? 


Kakuri Omari, Ph.D. Albert Einstein College of Medicine Bronx, NY

Project Number: FG 1422-A-1

Funding: $111,120

Term: 4/1/02 to 3/31/05

Category: Immunology

“Chemokine receptor expression in the central nervous system”

Exploring the presence and function of immune-system molecules and their docking proteins in MS brain lesions.

Funded in part through gifts from the Manhattan Society of the NMSS New York City Chapter


Andras Perl, M.D., Ph.D. SUNY Health Science Center at Syracuse Syracuse, NY

Project Number: RG 2466B2/3

Funding: $474,398

Term: 4/1/00 to 9/30/04

Category: Immunology

“Autoimmunity to transaldolase in MS”

Determining the role of an enzyme of myelin in generating the destructive immune attack in MS. 


Cedric Raine, D.Sc., Ph.D. Albert Einstein College of Medicine Bronx, NY

Project Number: RG 1001J10/2

Funding: $315,761

Term: 4/1/00 to 9/30/04

Category: Immunology

“Remyelination in MS and EAE: influence of immune mediators”

Investigating the roles of immune-modulating chemicals in the destruction of myelin-making cells in MS. 


Murali Ramanathan, Ph.D. State University of New York at Buffalo Buffalo, NY

Project Number: RG 3258A2/1

Funding: $534,823

Term: 9/30/01 to 9/30/04

Category: Immunology

“The study of mRNA expression profiles in multiple sclerosis”

Identifying changes in the immune systems of people with MS that may help to predict neurologic damage, disability and response to therapy. 


Marilyn Resh, Ph.D. Memorial Sloan Kettering Cancer Institute New York, NY

Project Number: RG 3235-A-2

Funding: $377,768

Term: 4/1/01 to 9/30/04

Category: Biology of Glia

“Identification of activated Fyn substrates in differentiating oligodendrocytes”

Identifying proteins involved in the maturation of myelin-making cells, for clues to ways to stimulate myelin repair in MS.

Funded in part by a gift from the Manhattan Society and the Associates Committee of the NMSS New York City Chapter 


William Rooney, Ph.D. Brookhaven National Laboratory Upton, NY

Project Number: RG 3168A1/1

Funding: $613,687

Term: 9/30/00 to 9/30/04

Category: Neuropathology

“Quantitation of blood-brain barrier permeability in MS lesion development”

Using magnetic resonance imaging to track and measure MS lesion development in early stages of the disease. 


Jack Rosenbluth, M.D. New York University Medical Center New York, NY

Project Number: RG 2539-C-7

Funding: $351,368

Term: 9/30/00 to 9/30/04

Category: Biology of Glia

“Pathology of demyelination”

Studying aspects of the interaction between myelin and nerve fibers for clues to how nerve conduction may be disrupted in MS. 


James Salzer, M.D., Ph.D. New York University Medical Center New York, NY

Project Number: RG 3439-A-9

Funding: $516,063

Term: 4/1/03 to 3/31/07

Category: Biology of Glia

“Axonal-glial interactions at the paranodes”

Exploring how nerve fibers and myelin interact to maintain proper nerve fiber function.

Funded in part by a gift from the NMSS New York City chapter 


James Salzer, M.D., Ph.D. New York University Medical Center New York, NY

Project Number: RG 2311-C-6

Funding: $300,823

Term: 4/1/01 to 3/31/05

Category: Biology of Glia

“Axonal regulation of myelinating glia: roles of neuregulin and signalingpathways”

Determining whether growth molecules on nerve fibers play a critical role in the formation of the myelin sheathes that envelopes them. 


Christian Schindler, M.D., Ph.D. Columbia University New York, NY

Project Number: RG 3237-A-1

Funding: $448,737

Term: 4/1/01 to 3/31/05

Category: Immunology

“Alpha/beta interferon signaling in the treatment of MS”

Understanding better how interferon-beta modulates the immune response in MS-like disease.


Steven Schwid, M.D. University of Rochester Medical Center Rochester, NY

Project Number: RG 3571-A-3

Funding: $109,955

Term: 12/1/03 to 11/30/04

Category: Therapy/Management of MS

“Establishing a Multiple Sclerosis cooperative research group - a planning grantproposal”

Planning the creation of a research team to conduct multi-center clinical research related to MS. 


Benjamin Segal, M.D. University of Rochester Rochester, NY

Project Number: JF 2098A1/1

Funding: $530,295

Term: 7/1/00 to 6/30/05

Category: Immunology

“The role of interleukin-12 during the effector phase of EAE”

Evaluating the function of a messenger chemical of the immune system and its role in stimulating the immune attack in MS-like disease.

Funded in part by the Dave Tomlinson Research Fund through the NMSS Mid- America Chapter 


Bridget Shafit-Zagardo, Ph.D. Albert Einstein College of Medicine Bronx, NY

Project Number: RG 3020-B-4

Funding: $402,636

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Survival factors for human oligodendrocytes: implications for MS”

Studying molecules that may have the power to protect myelin-making cells from dysfunction and death in MS.

Funded in full by an anonymous donor through the NMSS New York City Chapter 


Janet Shucard, Ph.D. State University of New York at Buffalo Buffalo, NY

Project Number: PP0871

Funding: $36,000

Term: 9/1/02 to 8/31/04

Category: Psychosocial Aspects of MS

“Electrophysiological measures of processing speed & working memory deficits inMS”

Developing a method of measuring mild cognitive dysfunction in MS. 


Peter Werner, Ph.D. Albert Einstein College of Medicine Bronx, NY

Project Number: PP0988

Funding: $44,000

Term: 3/1/04 to 2/28/05

Category: Neuropathology

“AMPA/KA receptors & blood brain barrier integrity in MS and EAE”

Determining the roles of specific molecules that may allow the immune attack to breach the brain and spinal cord in MS. 


NORTH CAROLINA
Robert Buchanan, Ph.D.
University of North Carolina at Charlotte Charlotte, NC

Project Number: HC 0043T

Funding: $352,044

Term: 10/1/03 to 6/30/05

Category: Health Care Delivery/Policy

“The long-term care needs of people with multiple sclerosis”

Exploring the longterm care needs of people with MS and the services they receive in care facilities. 


Robert Buchanan, Ph.D. University of North Carolina at Charlotte Charlotte, NC

Project Number: HC 0038T

Funding: $165,284

Term: 10/1/03 to 6/30/04

Category: Health Care Delivery/Policy

“Delivery of health care to people with multiple sclerosis living in rural areas”

Profiling how people with MS in rural areas utilize health care and barriers to access they may encounter. 


Susanna Greer, Ph.D. University of North Carolina at Chapel Hill Chapel Hill, NC

Project Number: TA 3005A2

Funding: $559,189

Term: 8/1/03 to 7/31/08

Category: Immunology

“Ubiquitination Regulates CIITA activity and MHC II expression on microglia”

Investigating whether molecules involved in activating the immune attack help to control the onset or progression of MS. 


OHIO
Francois Bethoux, M.D.
Cleveland Clinic Foundation Cleveland, OH

Project Number: HC 0033T

Funding: $246,805

Term: 7/1/02 to 6/30/04

Category: Rehabilitation

“Trial of rehabilitation following acute relapses of MS”

Determining the value of comprehensive rehabilitation in recovery from an MS flare-up. 


Melissa Callahan, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FG 1482-A-1

Funding: $130,947

Term: 8/1/02 to 7/31/05

Category: Immunology

“Mononuclear cell chemokine receptors: In vitro studies”

Using an advanced, artificial membrane to test ways to block signals that attract destructive immune cells into the brain and spinal cord in MS. 


Astrid Cardona, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FG 1528-A-1

Funding: $130,947

Term: 8/1/03 to 7/31/06

Category: Immunology

“Role of CX3CR1 in microglia activation in vivo: effect of inflammatory andneurotoxic stimuli”

Evaluating the role of a protein docking site in modulating brain cells that are active in the immune attack on the brain and spinal cord in MS. 


Andrea Edling, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FA 1445-A-1

Funding: $130,215

Term: 7/1/01 to 6/30/04

Category: Immunology

“Bone marrow regeneration of autoreactivity in experimental allergicencephalomyelitis”

Testing whether persistence of the immune attack in chronic MSlike disease is affected by factors in bone marrow cells. 


Thomas Forsthuber, M.D., Ph.D. Case Western Reserve University Cleveland, OH

Project Number: RG 3499-A-3

Funding: $473,042

Term: 10/1/03 to 9/30/06

Category: Immunology

“The role of macrophage migration inhibitory factor (MIF) in EAE”

Evaluating the role of an immune messenger protein that may contribute to the immune attack in an MS-like disease in mice by prolonging the life of inflammatory immune cells. 


Thomas Forsthuber, M.D., Ph.D. Case Western Reserve University Cleveland, OH

Project Number: RG 3322A2/2

Funding: $178,296

Term: 10/1/02 to 9/30/05

Category: Immunology

“Avidity maturation of T cells in multiple sclerosis”

Identifying the protein target of immune T cells and their activity in the development of MS. 


Myla Goldman, M.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FP 1521-A-1

Funding: $120,500

Term: 8/1/03 to 7/31/06

Category: Therapy/Management of MS

“Sylvia Lawry Physician Fellowship”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


Tatyana Gudz, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: PP0944

Funding: $44,000

Term: 9/1/03 to 8/31/04

Category: CNS Repair

“Mechanisms of oligodendrocyte adhesion and migration: modulation byglutamate”

Understanding the mechanisms that control movement of myelin-making cells, for clues to enhancing myelin repair. 


Wendy Macklin, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: RG 3290A6/1

Funding: $461,129

Term: 4/1/02 to 3/31/05

Category: Biology of Glia

“Neuregulin function in oligodendrocytes”

Understanding how proteins on the surface of nerve fibers influence the growth and survival of myelin-making cells. 


Ruth Ann Marrie, M.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FP 1424-A-1

Funding: $120,500

Term: 7/1/01 to 6/30/04

Category: Psychosocial Aspects of MS

“Effects of cognitive impairment on the validity of a patient self-report measure”

Receiving training on the proper ways to conduct clinical treatment trials in MS. 


Jennifer McDonough, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FA 1507A1/1

Funding: $154,745

Term: 8/1/03 to 7/31/06

Category: Neuropathology

“Identification of genes involved in neuronal pathology in multiple sclerosis”

Understanding the mechanisms that lead to nerve cell injury in MS, and identifying strategies to protect these cells. 


Martha Miller, M.D., Ph.D. Case Western Reserve University Cleveland, OH

Project Number: PP0913

Funding: $44,000

Term: 5/1/03 to 4/30/04

Category: Neuropathology

“Proteolipid protein expression in neurons in the developing brainstem”

Exploring the role that a myelin protein may play in the development of nerve cells, and in their injury in MS. 


Ioana Moldovan, M.D., Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FA 1459-A-1

Funding: $148,555

Term: 7/1/01 to 6/30/04

Category: Immunology

“Gender differences in immune responses in multiple sclerosis”

Investigating differences in immune responses against nerve-insulating myelin between men and women with MS. 


Jacqueline Morris, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: FA 1464-A-1

Funding: $147,556

Term: 7/1/01 to 6/30/04

Category: Biology of Glia

“The molecular mechanisms that control myelination”

Determining mechanisms involved in myelin formation for clues to stimulating myelin repair in MS.

Funded in part by the NMSS Ohio Valley Chapter 


Tracey Papenfuss, D.V.M. Ohio State University Columbus, OH

Project Number: FG 1555-A-1

Funding: $148,265

Term: 8/1/03 to 7/31/06

Category: Immunology

“Biased antigen presenting cells influence autoimmune T cells: Implications forEAE”

Investigating how cells that activate the immune attack can influence the formation of inflammatory or suppressive immune cells, and the possible treatment benefits in an MS-like disease in mice. 


Clara Pelfrey, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: RG 3263-A-3

Funding: $251,190

Term: 4/1/01 to 9/30/04

Category: Immunology

“Gender differences in immune responses in MS”

Determining in what ways the immune attack that leads to MS is different in men and women who have the disease. 


Clara Pelfrey, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: RG 3005-B-4

Funding: $479,190

Term: 4/1/04 to 3/31/07

Category: Immunology

“Longitudinal immune- and neurotrophic-cytokine responses in MS”

Correlating immune activity during MS attacks with clinical/MRI measures MS and progression. 


Richard Ransohoff, M.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: PP0857/T

Funding: $7,644

Term: 5/1/02 to 4/30/04

Category: Immunology

“Study of MCP-1 expression in transgenic animal models”

Developing new tools to understand how immune cells are attracted to enter and damage brain and spinal cord tissue in MS-like disease. 


Richard Rudick, M.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: RG 3099-A-4

Funding: $515,092

Term: 9/30/99 to 9/30/04

Category: Measuring Disease Activity

“Monitoring brain atrophy during the course of multiple sclerosis”

Using magnetic resonance techniques to measure nervous tissue destruction in MS, to improve methods of testing new therapies. 


Phillip Rumrill, PhD, CRC Kent State University Kent, OH

Project Number: HC 0046

Funding: $437,790

Term: 7/1/01 to 6/30/04

Category: Health Care Delivery/Policy

“MS employment project”

Assessing the employment concerns and needs of people with MS using a national survey.


Lael Stone, M.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: RG 3223A2/1

Funding: $401,859

Term: 9/30/01 to 9/30/04

Category: Measuring MS Disease Activity

“The predictive value of MRI in multiple sclerosis”

Determining whether specific methods of MRI can predict the onset of disability in people with MS. 


Bruce Trapp, Ph.D. Cleveland Clinic Foundation Cleveland, OH

Project Number: CA 1032-A-5

Funding: $825,000

Term: 4/1/04 to 3/31/09

Category: CNS Repair

“Collaborative MS Research Center Award”

Searching for ways to stimulate immature cells that may generate new nerve-insulating myelin after it is destroyed by MS. 


OREGON
Bruce Bebo, Ph.D.
Oregon Health & Science University Beaverton, OR

Project Number: RG 3435-A-3

Funding: $149,573

Term: 4/1/03 to 3/31/06

Category: Immunology

“Mechanism of EAE suppression with non-steroidal estrogens”

Exploring the use of a plant-derived hormone similar to estrogen to treat an MS-like disease in mice, for clues to its possible use in humans. 


Dennis Bourdette, M.D. Oregon Health & Science University Portland, OR

Project Number: PP0921

Funding: $44,000

Term: 5/1/03 to 4/30/04

Category: Psychosocial Aspects of MS

“Ginkgo biloba as symptomatic therapy for cognitive dysfunction in multiplesclerosis”

Conducting a clinical trial to assess a method of treating cognitive problems in MS. 


Abigail Buenafe, Ph.D. Oregon Health & Science University Portland, OR

Project Number: RG 3259A1/1

Funding: $423,017

Term: 9/30/01 to 9/30/04

Category: Immunology

“Molecular interactions of myelin basic protein-specific T cell receptor”

Determining how immune cells recognize their myelin protein targets during the attack in MS-like disease. 


Gianni Maddalozzo, Ph.D. Oregon State University Corvallis, OR

Project Number: PP0848

Funding: $33,000

Term: 2/1/02 to 1/31/05

Category: Rehabilitation

“Fracture risk, fall risk, falls and bone density in women with multiple sclerosis”

Defining physical and psychological factors that may predict falls in women with MS. 


Halina Offner, Ph.D. Oregon Health & Science University Portland, OR

Project Number: RD 3405-A-2

Funding: $641,268

Term: 8/1/02 to 7/31/06

Category: Immunology

“Immunoregulatory effects of estrogen in EAE”

Determining how the female sex hormone estrogen inhibits immune-system responses in an MS-like disease in mice. 


Lawrence Sherman, Ph.D. Oregon Health & Science University Beaverton, OR

Project Number: PP0975

Funding: $44,000

Term: 2/1/04 to 1/31/05

Category: Biology of Glia

“Role of hyaluronan in inhibition of remyelination”

Exploring a molecule that may inhibit myelin repair in MS, for clues to developing treatments aimed at myelin repair. 


Arthur Vandenbark, Ph.D. Veterans Administration Medical Center Portland, OR

Project Number: RG 3468A5/1

Funding: $542,398

Term: 4/1/04 to 3/31/07

Category: Immunology

“Epitope specific regulation of EAE with recombinant TCR ligands”

Developing a highly targeted experimental therapy that aims to inhibit only those immune T cells involved in MS attacks. 


Arthur Vandenbark, Ph.D. Veterans Administration Medical Center Portland, OR

Project Number: RG 3400A4/1

Funding: $469,902

Term: 4/1/03 to 3/31/06

Category: Immunology

“T cell receptor-specific regulatory T cells in multiple sclerosis”

Understanding the regulation of immune cells in MS, and the role of an experimental peptide therapy to control damage. 


Chunhe Wang, Ph.D. Oregon Health & Science University Portland, OR

Project Number: PP0898

Funding: $44,000

Term: 1/1/03 to 6/30/04

Category: Immunology

“Are alpha-B crystallin-specific T cells from gene knock-out miceencephalitogenic?”

Defining the role of a myelin-related protein in the immune attack on myelin in an MS-like disease in mice. 


PENNSYLVANIA
Michael Baime, M.D.
University of Pennsylvania Philadelphia, PA

Project Number: PP0972

Funding: $44,000

Term: 2/1/04 to 1/31/05

Category: Psychosocial Aspects of MS

“Mindfulness-based stress management for people with MS and their caregivers”

Examining the effects of a stress reduction strategies in people with MS and their caregivers. 


Laura Balcer, M.D. University of Pennsylvania Philadelphia, PA

Project Number: RG 3428A2/1

Funding: $34,619

Term: 10/1/03 to 9/30/08

Category: Measuring MS Disease Activity

“Longitudinal assessment of visual function in multiple sclerosis”

Tracking changes in visual function and quality of life over time in people with MS, and identifying the best methods for vision testing in MS clinical trials. 


Laura Balcer, M.D. University of Pennsylvania Philadelphia, PA

Project Number: RG 3208-A-1

Funding: $607,749

Term: 9/30/00 to 9/30/05

Category: Measuring MS Disease Activity

“Vision, MRI lesion burden, and quality of life in MS”

Exploring vision loss in people with MS and how it relates to other neurologic functions and quality of life. 


Elizabeth Blankenhorn, Ph.D. MCP Hahnemann University Philadelphia, PA

Project Number: RG 3276-A-4

Funding: $405,999

Term: 9/30/01 to 9/30/04

Category: Immunology

“Correlation of immune response phenotypes with EAE genetic susceptibility”

Linking genes that make mice susceptible to developing an MS-like disease to specific types of immune-system responses. 


Jayasri DasSarma, Ph.D. University of Pennsylvania Philadelphia, PA

Project Number: FA 1431-A-1

Funding: $149,055

Term: 7/1/01 to 6/30/04

Category: Neuropathology

“The role of gap junctions in mouse hepatitis virus (MHV) induceddemyelination”

Exploring the idea that communication between cells in the brain can be disrupted by viral infection in MS-like disease.


Jerome Devaux, Ph.D. University of Pennsylvania Medical Center Philadelphia, PA

Project Number: FG 1490A1/1

Funding: $141,771

Term: 1/1/04 to 12/31/06

Category: Biology of Glia

“Visualizing abnormal axonal conduction at the single cell level”

Developing a method of visualizing abnormalities in nerve fibers that may lead to abnormal nerve impulse conduction, for clues to improving nerve conduction in MS. 


Bruno Gran, M.D. Thomas Jefferson University Philadelphia, PA

Project Number: RG 3570A1/T

Funding: $67,410

Term: 5/1/03 to 7/31/05

Category: Immunology

“Role of IL-12 and IL-12 receptor in the pathogenesis of EAE”

Determining the complex role of a key immune messenger protein in the immune attack in MS-like disease. 


Takayuki Itoh, M.D., Ph.D. Children's Hospital of Philadelphia Philadelphia, PA

Project Number: RG 3419A1/1

Funding: $411,678

Term: 10/1/03 to 9/30/06

Category: Biology of Glia

“Regulation of oligodendroglial death by the Bc1 family”

Analyzing how certain proteins affect the survival of myelin-making cells, to improve understanding of how these cells are damaged in MS. 


Steven Levison, Ph.D. Pennsylvania State University Hershey, PA

Project Number: RG 2829B3/1

Funding: $386,681

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Roles of ciliary neurotrophic factor in remyelination”

Studying a molecule that may provide signals the promote myelin repair in an MS-like disease in mice. 


Jeffrey Mason, Ph.D. Thomas Jefferson University Philadelphia, PA

Project Number: PP0987

Funding: $44,000

Term: 3/1/04 to 2/28/05

Category: Neuropathology

“The ability of T-lymphocytes to induce axonal degeneration”

Investigating the role of immune cells in the damage to nerve fibers in models of MS. 


David Pleasure, M.D. Children's Hospital of Philadelphia Philadelphia, PA

Project Number: RG 3523-A-3

Funding: $400,382

Term: 4/1/04 to 3/31/07

Category: Biology of Glia

“Excitotoxicity in experimental allergic encephalomyelitis”

The role of overstimulation of nerve and myelin-making cells in MS tissue damage, and whether it can be blocked to treat the disease. 


Abdolmohamad Rostami, M.D., Ph.D. (TRANSFER PENDING) Thomas Jefferson University Philadelphia, PA

Project Number: RG 2991A1/1

Funding: $147,890

Term: 4/1/04 to 3/31/05

Category: Immunology

“Mechanisms of tolerance induced by i.v. MBP in EAE”

Teaching the immune system to tolerate nerve-insulating myelin, with an aim to suppressing the MSassociated immune attack.


SOUTH DAKOTA
Robin Miskimins, Ph.D.
University of South Dakota Vermillion, SD

Project Number: RG 2079-D-6

Funding: $301,562

Term: 10/1/02 to 9/30/05

Category: Biology of Glia

“Molecular analysis of myelin basic protein gene expression”

Understanding the genetic control of a protein in nerve-insulating myelin, and its function in myelin growth and repair. 


Robin Miskimins, Ph.D. University of South Dakota Vermillion, SD

Project Number: RG 3293-A-5

Funding: $327,403

Term: 9/30/01 to 9/30/04

Category: Biology of Glia

“Cell cycle control in oligodendrocyte development”

Examining the role of a protein in the development of myelin-making cells and the formation of myelin. 


TENNESSEE
Bruce Appel, Ph.D.
Vanderbilt University Nashville, TN

Project Number: RG 3420-A-1

Funding: $385,761

Term: 4/1/03 to 3/31/06

Category: Biology of Glia

“Control of oligodendrocyte proliferation & differentiation by notch signaling”

Investigating the molecular mechanisms that regulate the development of myelinmaking cells, for clues to repairing tissue damage caused by MS. 


Xinqing Deng, M.D. Vanderbilt University Nashville, TN

Project Number: FG 1540-A-1

Funding: $141,771

Term: 8/1/03 to 7/31/06

Category: Measuring MS Disease Activity

“Expression of pro-survival genes in multiple sclerosis”

Examining patterns of genes that regulate immune cell survival in people with MS and in their family members for clues to understanding the persistence of the immune attack. 


TEXAS
Asim Diab, M.D., Ph.D.
University of Texas Southwestern Medical Center Dallas, TX

Project Number: FA 1468-A-1

Funding: $135,469

Term: 7/1/01 to 6/30/04

Category: Immunology

“Role of peroxisome proliferator-activated receptors in CNS autoimmunedemyelination”

Evaluating the immune effects of a novel compound and whether it can suppress inflammation and inhibit MS-like disease in mice. 


Nitin Karandikar, M.D., Ph.D. University of Texas Southwestern Medical Center Dallas, TX

Project Number: JF 2118-A-2

Funding: $638,000

Term: 1/1/04 to 12/31/08

Category: Immunology

“Therapeutic modulation of autoreactive T cell responses in multiple sclerosis”

Characterizing specific immune responses mounted by different subtypes of immune cells in people with MS, for clues to stopping the attack. 


Qing Lu, Ph.D. UT Southwestern Medical Center at Dallas Dallas, TX

Project Number: JF 2115-A-1

Funding: $576,760

Term: 8/1/03 to 7/31/08

Category: Biology of Glia

“Genetic mechanisms of oligodendrocyte development”

Understanding the mechanisms involved in the development of cells that make nerve-insulating myelin, to facilitate therapeutic strategies that will stimulate myelin repair in MS. 


Nancy Monson, Ph.D. UT Southwestern Medical Center at Dallas Dallas, TX

Project Number: RG 3267-A-1

Funding: $298,673

Term: 4/1/01 to 3/31/05

Category: Immunology

“Molecular analysis of the Ig repertoire in MS”

Determining if immune cells produce significant antibodies that mark myelin and nerve cells for attack in MS. 


Michael Racke, M.D. University of Texas Southwestern Medical Center Dallas, TX

Project Number: RG 3427-A-8

Funding: $418,011

Term: 4/1/03 to 3/31/06

Category: Immunology

“Peroxisome proliferator-activated receptor agonists as treatment forautoimmune demyelination”

Testing whether anti-inflammatory molecules can improve an MS-like disease in mice, for clues to a new approach to treating MS in humans. 


Michael Racke, M.D. University of Texas Southwestern Medical Center Dallas, TX

Project Number: RG 2969-B-7

Funding: $103,320

Term: 10/1/02 to 9/30/06

Category: Immunology

“T cell activation requirement in autoimmune demyelination”

Exploring factors that influence the activation of immune T cells in MS-like disease and possible ways to stop that activation in MS. 


E. Sally Ward, Ph.D. University of Texas Southwestern Medical School Dallas, TX

Project Number: RG 2411-E-5

Funding: $663,661

Term: 4/1/04 to 3/31/08

Category: Immunology

“T cell recognition of peptide-MHC conformers in murine EAE”

Exploring factors involved when immune T cells become activated against brain and spinal cord tissues in MS, and ways to intervene. 


UTAH
John Rose, M.D.
University of Utah Salt Lake City, UT

Project Number: RG 3411-A-3

Funding: $614,900

Term: 4/1/03 to 3/31/07

Category: Neuropathology

“The role of cyclooxygenase in multiple sclerosis”

Understanding how the immune attack in MS might also harm myelin-making cells and exploring ways to overcome this inhibition to repair. 


VERMONT
Cory Teuscher, Ph.D.
University of Vermont Burlington, VT

Project Number: RG 3129A3/T

Funding: $267,468

Term: 4/1/02 to 3/31/05

Category: Immunology

“Genetic basis for gender differences in EAE susceptibility”

Finding genes that control differences in susceptibility to MS-like disease between the sexes, for clues to underlying factors in MS. 


VIRGINIA
Babette Fuss, Ph.D.
Virginia Commonwealth University Richmond, VA

Project Number: RG 3434A3/1

Funding: $126,279

Term: 10/1/03 to 9/30/06

Category: Biology of Glia

“Novel molecular mechanisms in oligodendrocytes”

Investigating chemicals released by myelin-making cells which may affect myelin formation, to gain insights into promoting myelin repair in MS. 


Carmen Sato-Bigbee, Ph.D. Virginia Commonwealth University Richmond, VA

Project Number: RG 3432A2/2

Funding: $547,118

Term: 4/1/04 to 3/31/08

Category: Biology of Glia

“Molecular mechanisms of neurotrophin-3 action in oligodendrocytes”

Investigating factors that may regulate the ability of brain cells to develop into mature cells capable of repairing myelin destroyed by MS. 


WASHINGTON
Joan Goverman, Ph.D.
University of Washington Seattle, WA

Project Number: RG 3328-A-4

Funding: $264,000

Term: 4/1/02 to 3/31/06

Category: Immunology

“Regulatory T cells in MBP-specific autoimmunity”

Investigating immune cells that appear capable of preventing immune attacks for clues to new MS therapies. 


WISCONSIN
Shing-yan Chiu, Ph.D.
University of Wisconsin-Madison Madison, WI

Project Number: RG 3247-A-6

Funding: $396,380

Term: 4/1/01 to 9/30/04

Category: Neuropathology

“Axonal calcium and its role in axonal degeneration in dysmyelination”

Determining whether an influx of calcium in nerve fibers may contribute to their damage and loss in MS.

Paid in full by the Estate of Norman Cohn


Bonnie Dittel, Ph.D. The Blood Center of Southeastern Wisconsin Milwaukee, WI

Project Number: RG 3299-A-2

Funding: $483,533

Term: 9/30/01 to 9/30/04

Category: Immunology

“Immune regulation by B cells in the recovery from EAE”

Determining how immune B cells may participate in recovery from MS-like disease. 


Ian Duncan, Ph.D. University of Wisconsin-Madison Madison, WI

Project Number: RG 3472A8/1

Funding: $413,576

Term: 4/1/04 to 3/31/07

Category: Immunology

“Modulation of microglia by minocycline in CNS disease”

Can an antibiotic inhibit immune activity and protect nerve cells in MS-like disease, and does it has promise for treating MS? 


Ian Duncan, Ph.D. University of Wisconsin-Madison Madison, WI

Project Number: PP0957

Funding: $44,000

Term: 9/30/03 to 9/30/04

Category: Biology of Glia

“The expression of axon regeneration inhibitors in myelin mutant rats”

Investigating proteins that may inhibit the regeneration of nerve fibers in MS. 


Colleen Hayes, Ph.D. University of Wisconsin-Madison Madison, WI

Project Number: RG 3107B3/1

Funding: $467,660

Term: 10/1/03 to 9/30/06

Category: Immunology

“Vitamin D regulation of autoimmune encephalomyelitis”

Understanding how a hormone is produced in the brain and spinal cord during inflammation, and how this hormone may help to resolve inflammation in an MS-like disease in mice. 


Konstance Knox, Ph.D. Institute for Viral Pathogenesis Milwaukee, WI

Project Number: PP0919

Funding: $44,000

Term: 6/1/03 to 5/31/04

Category: Infectious Agents

“Human herpesvirus six and multiple sclerosis: molecular mimicry”

Exploring the association between the virus HHV-6 and multiple sclerosis. 


Alexander Ng, Ph.D. Marquette University Milwaukee, WI

Project Number: RG 2208D5/2

Funding: $409,383

Term: 9/30/00 to 9/30/04

Category: Rehabilitation

“Autonomic function and fatigue in multiple sclerosis”

Investigating cardiovascular function in MS and its relationship to fatigue. 


Jonathan Song, Ph.D. University of Wisconsin-Madison Madison, WI

Project Number: RG 3389-A-2

Funding: $363,463

Term: 10/1/02 to 9/30/05

Category: Biology of Glia

“Identification of oligodendrocyte subtypes”

Clarifying differences in subtypes of myelin-making cells in the brain and spinal cord, and factors that influence their development and function. 


INTERNATIONAL GRANTS 
AUSTRALIA
Claude Bernard, D.Sc., Ph.D.
La Trobe University Bundoora

Project Number: RG 3319A1/1

Funding: $262,926

Term: 4/1/02 to 3/31/05

Category: Neuropathology

“Is axonal damage the basis of clinical deterioration in murine MS models?”

Evaluating the extent of nerve fiber damage in different types of MS-like disease to determine its role in disease course and potential for repair in MS. 


Judith Greer, Ph.D. The University of Queensland Brisbane

Project Number: RG 3190-A-1

Funding: $523,196

Term: 9/30/00 to 9/30/04

Category: Immunology

“HLA type, B & T cell responses to myelin antigens, and lesion distribution”

Exploring genetic and immune factors that may determine which areas of the brain and spinal cord become targets in MS. 


Trevor Kilpatrick, M.B.B.S., Ph.D. Howard Florey Inst of Exptal Physiology & Medicine Victoria

Project Number: RG 3284A2/1T

Funding: $183,889

Term: 1/1/04 to 6/30/05

Category: Biology of Glia

“Role of inhibitory factor signaling in modulating oligodendrocyte survival &demyelination”

Exploring how a natural protein influences the survival of myelinmaking cells and protects mice from symptoms of MS-like disease. 


Shaun McColl, Ph.D. University of Adelaide Adelaide

Project Number: RG 3331A1/1

Funding: $285,354

Term: 10/1/02 to 9/30/05

Category: Immunology

“Chemokine receptors as potential therapeutic targets in MS”

Targeting molecules that attract immune cells into the brain and spinal cord with experimental therapies to stop the immune attack. in MS-like disease. 


Anthony McMichael, M.B.B.S., Ph.D. The Australian National University Canberra

Project Number: RG 3364A1/2

Funding: $617,717

Term: 4/1/03 to 3/31/08

Category: Epidemiology

“A case control study of past sun exposure and first demyelinating events”

Investigating whether sunlight exposure reduces the risk of developing MS. 


CANADA
David Colman, Ph.D.
McGill University Montreal QC

Project Number: RG 3217A8/T

Funding: $208,340

Term: 1/1/04 to 3/31/07

Category: CNS Repair

“Molecular architecture of axoglial junction”

Exploring the structure and interaction of molecules that make up nerve-insulating myelin. 


Trevor Owens, Ph.D. Montreal Neurological Institute Montreal Quebec

Project Number: RG 3382-A-2

Funding: $224,838

Term: 10/1/02 to 9/30/05

Category: Immunology

“Costimulation in an animal model for MS”

Investigating an immune mechanism crucial to the activation of the immune attack in MS and MS-like disease and possible ways to circumvent it. 


John Carling Roder, Ph.D. Samuel Lunenfeld Research Institute Toronto

Project Number: RG 3295-A-1

Funding: $407,622

Term: 9/30/01 to 9/30/04

Category: Immunology

“A forward genetic screen for MS susceptibility genes in animal models”

Identifying genetic mutations that cause neurologic disabilities in mice, for clues to genes involved in susceptibility to human MS. 


Peter Stys, M.D, FRCP Ottawa Civic Hospital Loeb Medical Research Inst. Ottawa, ON

Project Number: RG 3424-A-1

Funding: $333,057

Term: 4/1/03 to 3/31/06

Category: Neuropathology

“Intracellular calcium dynamics in myelinated axons”

Understanding how calcium-activated enzymes in damaged nerve fibers contribute to nerve fiber dysfunction and death. 


CYPRUS
Christina Christodoulou, Ph.D.
The Cyprus Institute of Neurology and Genetics Nicosia

Project Number: RG 3321A1/2

Funding: $241,065

Term: 4/1/03 to 3/31/06

Category: Measuring MS Disease Activity

“Herpesviruses as possible etiology of MS”

Investigating a possible role of HHV-6 virus as a trigger for MS. 


Kleopas Kleopa, M.D. The Cyprus Institute of Neurology and Genetics Nicosia

Project Number: RG 3457A2/1

Funding: $219,750

Term: 4/1/04 to 3/31/07

Category: Biology of Glia

“CNS connexins and demyelination in CMTX”

Understanding the involvement of a protein that may play a critical role in the health and damage of nerve-insulating myelin and nerve fibers. 


Kleopas Kleopa, M.D. The Cyprus Institute of Neurology and Genetics Nicosia

Project Number: RG 3454A1/T

Funding: $45,721

Term: 9/1/02 to 6/30/04

Category: Biology of Glia

“Connexin 32 mutations and central demyelination”

Studying how a crucial structural protein may help maintain myelin integrity and also play a role in its destruction. 


ENGLAND
Holly Colognato, Ph.D.
University of Cambridge Cambridge

Project Number: TA 3002A1

Funding: $559,189

Term: 8/1/03 to 7/31/08

Category: Biology of Glia

“The regulation of oligodendrocyte survival and myelination by lamininsignaling”

Increasing knowledge about how production of nerve-insulating myelin is regulated, and how this process can be corrected in MS. 


Alastair Compston, M.D. University of Cambridge Cambridge

Project Number: RG 3500-A-1

Funding: $184,000

Term: 10/1/03 to 9/30/04

Category: Human Genetics

“Refining association with chromosome 19q13 in multiple sclerosis”

Evaluating whether specific genes within a region of a chromosome contribute to susceptibility to developing MS in European populations. 


Lindsay Nicholson, Ph.D. University of Bristol Bristol

Project Number: RG 3257A2/T

Funding: $241,172

Term: 8/1/03 to 3/31/05

Category: Immunology

“The role of low avidity cross-reactive T cells in the regulation of EAE”

Developing a potential therapy that attempts to boost the immune system's ability to turn off an attack in MS-like disease. 


FRANCE
Michel Brahic, M.D., Ph.D.
Institut Pasteur Paris

Project Number: RG 3327-A-8

Funding: $191,290

Term: 4/1/02 to 3/31/05

Category: Infectious Agents

“Roles of neurons, oligodendrocytes & macrophages in Theiler's virus”

How a mouse virus infects brain cells and what factors permit it to reside and persist and ultimately cause MS-like disease. 


Jean-Antoine Girault, M.D., Ph.D. Institut du Fer a Moulin Paris

Project Number: RG 3535-A-1

Funding: $265,455

Term: 4/1/04 to 3/31/07

Category: Biology of Glia

“Axoglial contacts: molecular organization and role in signaling”

Molecular controls over the formation and function of crucial sites on nerve fibers where the nerve cell and its myelin coating communicate. 


GERMANY
Albrecht Neiss, Ph.D.
Technical University of Munich Munich

Project Number: RG 3325-A-1

Funding: $800,000

Term: 7/1/01 to 6/30/05

Category: Therapy/Management of MS

“Sylvia Lawry Center for Multiple Sclerosis Research”

Collecting and analyzing MRI and clinical data from MS drug trials to increase knowledge of the natural history of the disease and to speed the development of new treatments. 


Markus Schwab, Ph.D. Max Planck Institute of Experimental Medicine Gottingen

Project Number: RG 3403A1/T

Funding: $61,724

Term: 2/1/02 to 7/31/04

Category: Biology of Glia

“Effects of the regulated expression of neuregulin isoforms on myelination”

Exploring conditions & a specific growth factor that favor the growth of myelinmaking cells and myelin repair. 


GREECE
Domna Karagogeos, Ph.D.
Foundation for Research and Technology- Hellas Heraklion

Project Number: RG 3368-A-1

Funding: $285,448

Term: 10/1/02 to 9/30/05

Category: Biology of Glia

“Functional and biochemical studies of the juxtaparanodal adhesion protein”

Exploring the properties of a protein that appears crucial to the interaction of nerve fibers and their myelin coating and proper nerve signaling. 


ISRAEL
Avraham Ben-Nun, Ph.D.
Weizmann Institute of Science Rehovot

Project Number: RG 3195A7/1

Funding: $366,660

Term: 4/1/01 to 9/30/04

Category: Immunology

“Synthetic gene products for multi-target-directed immunomodulation of EAE”

Designing and evaluating a therapy that attempts to target all known myelin components that may stimulate the immune attack in MS. 


Elior Peles, Ph.D. Weizmann Institute of Science Rehovot

Project Number: RG 3102-B-3

Funding: $415,770

Term: 10/1/03 to 9/30/06

Category: Biology of Glia

“Axon-glia interactions mediated by members of the caspr family”

Investigating the basic molecular mechanisms by which two proteins are crucial to the generation of a fully functional, myelin-insulated nerve fiber. 


ITALY
Carlo Antozzi, M.D.
National Neurological Institute Carlo Besta Milan

Project Number: RG 3282-A-1

Funding: $177,100

Term: 9/30/01 to 9/30/04

Category: Therapy/Management of MS

“IgG immunoadsorption in steroid-resistant relapses of MS: a pilot study”

A small clinical study of a novel immune-protein cleansing treatment for people with MS who do not respond to steroid therapy for acute attacks. 


Ernesto Bongarzone, Ph.D. Fondazione Centro San Raffaele Milano

Project Number: PP0947

Funding: $40,000

Term: 9/30/03 to 9/30/04

Category: CNS Repair

“Enhancing the capacity of neural stem cells to generate oligodendrocytes”

Examining factors that might enhance the capability of immature nerve cells to promote myelin repair in MS. 


Gabriela Constantin, M.D. University of Verona Verona

Project Number: RG 3369A2/2

Funding: $138,684

Term: 10/1/03 to 9/30/05

Category: Immunology

“Molecular mechanisms controlling lymphocyte recruitment in brain venules”

Studying molecular mechanisms that govern movement of immune cells from the blood to the brain and spinal cord to cause tissue damage in MS. 


Francesco Ria, M.D., Ph.D. The Catholic University Rome

Project Number: RG 3339-A-1

Funding: $231,750

Term: 4/1/02 to 3/31/05

Category: Immunology

“Definition and regulation of T cells specific for self-antigens of the CNS”

Tracking immune cells involved in the attack against brain tissue in MS-like disease.

Paid in full by the Estate of Norman Cohn 


NORTHERN IRELAND
Andrea Lowe-Strong, Ph.D.
University of Ulster at Jordanstown Belfast, Co. Antrim

Project Number: PP0977

Funding: $40,000

Term: 2/1/04 to 1/31/05

Category: Therapy/Management of MS

“The effectiveness of reflexology in the management of pain in multiple sclerosis”

Conducting a clinical trial of a complementary therapy to determine if it can relieve pain in people with MS. 


SWITZERLAND
Burkhard Becher, Ph.D.
University of Zurich Zurich

Project Number: JF 2109A2/T

Funding: $472,309

Term: 1/1/03 to 7/31/07

Category: Immunology

“The role of CNS-endogenous immune cells in and in vivo model of MS”

Exploring the role of brain cells in facilitating the immune-system attack against brain and spinal cord tissue in MS-like disease.
 

Copyright © 2004, National Multiple Sclerosis Society