Multiple Sclerosis, 1 February 2003, vol. 9, no. 1, pp. 44-54(11)
Feys P.; Helsen W.F.; Lavrysen A.; Nuttin B.; Ketelaer P.
 Katholieke Universiteit Leuven, Department of Kinesiology, Motor Learning Laboratory, Belgium  Katholieke Universiteit Leuven, Department of Neurosciences and Psychiatry, Belgium  National Multiple Sclerosis Center, Melsbroek, Belgium
Accurate goal-directed movements toward a visual target require a precise coordination of both the oculomotor and limb motor systems.
Intention tremor and eye movement deficits are frequently observed in multiple sclerosis (MS).
The goal of this study was to examine the characteristics of intention tremor and simultaneously produced eye movements during rapid goal-directed movements.
Eye and hand movements were synchronously measured in 16 MS patients with intention tremor and 16 control subjects.
Manual performances of the patient group were characterized by a delayed onset, slower execution and aiming inaccuracies.
In line with the clinically defined picture of intention tremor, differences between patients and control subjects were most pronounced toward the end of the movement.
Dependent variables were obviously greater in MS patients compared with control subjects, and correlated well with clinical outcome measures.
The application of an inertial load to the limb did not show any effect on intention tremor.
In addition to impaired limb coordination, evidence has been found that eye movements, too, were abnormal in patients compared with control subjects.
Moreover, eye and hand movement deficits seemed to be closely related, suggesting a common underlying command structure.
Inaccurate eye movements were likely to hamper an accurate motor performance of the hand.