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Multiple Sclerosis: Chemokine system may be of particular interest for leukocyte infiltration of CNS

http://www.NewsRx.net

February 10, 2003
Pain &  Central Nervous System Week

"Chemokines and their receptors govern physiologic and pathologic leukocyte trafficking," wrote R.M. Ransohoff and coauthors, Cleveland Clinic Foundation, Lerner Research Institute.

"The function of the chemokine system may be of particular interest for hematogenous leukocyte infiltration of the central nervous system (CNS) because of the distinct character of CNS inflammation and the exquisite specificity with which the chemokine system regulates cellular migration events." The researchers concluded: "This review summarizes recent information about the expression and function of elements of the chemokine system in CNS inflammatory processes. Animal models of CNS demyelinating disease and the corresponding human disorder, multiple sclerosis, are both considered."

Ransohoff and colleagues published their study in the Journal of Infectious Diseases (The chemokine system in neuroinflammation: An update. J Infec Dis, 2002;186(Suppl. 2):S152-S156).

The contact person for this report is R.M. Ransohoff, Cleveland Clinic Foundation, Lerner Research Institute, Dept. of Neuroscience, NC30, 9500 Euclid Ave., Cleveland, OH 44195, USA.

To subscribe to the Journal of Infectious Diseases, contact the publisher: University Chicago Press, 1427 E 60TH St., Chicago, IL 60637-2954, USA.

The information in this article comes under the major subject areas of Neurology.

This article was prepared by Pain &  Central Nervous System Week editors from staff and other reports.
 

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