More MS news articles for Mar 2002

Sandlike Appearance of Virchow-Robin Spaces in Early Multiple Sclerosis: A Novel Neuroradiologic Marker

American Journal of Neuroradiology 23:376-380, March 2002
Anat Achiron (a) and Meir Faibel (b)
(a) Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Israel
(b) Neuroradiology Unit, Sheba Medical Center, Tel-Hashomer, Israel


The distinctive hyperintensity of multiple sclerosis (MS) lesions on T2-weighted brain MR images is well recognized. However, Virchow-Robin spaces (VRSs), especially in early MS, have not been described. Our purpose was to determine the frequency of VRSs in recent-onset MS.


Brain MR imaging was performed in 71 patients (mean age, 26.8 years; range, 20–41 years; 47 women, 24 men) within 3 months of MS onset. Proton density–, T2-, and T1-weighted images were obtained. Age-and sex-matched control subjects (mean age, 27.2 years; range, 22–41 years; 38 women, 22 men) who underwent brain MR imaging as a part of headache evaluation, and findings that were interpreted as normal served as controls. On high-convexity images (axial sections above the upper corpus callosum border), VRSs were identified as small (<2-mm diameter) sandlike areas isointense to CSF. VRSs were graded 0–3.


VRSs were visualized in high-convexity white matter in 55% of patients and 7% of control subjects (P < .001). In patients, 15% of VRSs were grade 1 (fewer than four), 23% were grade 2 (four to seven), and 62% were grade 3 (more than seven). In control subjects, all identified VRSs were grade 1. Among patients with and those without VRSs, age at onset, neurologic disability, and specific functional system involvement or mono- versus polysymptomatic involvement at onset did not differ.


VRSs were more frequent in patients with recent-onset MS than in control subjects. The sandlike appearance of VRSs may be a neuroradiologic marker that reflects early inflammatory changes in MS.

© 2002 American Society of Neuroradiology