Proc Natl Acad Sci U S A 2002 Feb
Calza L, Fernandez M, Giuliani A, Aloe L, Giardino L.
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy; Pathophysiology Center for the Nervous System, Hesperia Hospital, 41100 Modena, Italy; and Institute of Neurobiology, Consiglio Nazionale delle Ricerche, 00137 Rome, Italy.
Remyelination in the adult central nervous system has been demonstrated in different experimental models of demyelinating diseases.
However, there is no clear evidence that remyelination occurs in multiple sclerosis, the most diffuse demyelinating disease.
In this article, we explore the possibility of promoting myelination in experimental allergic encephalomyelitis, a widely used experimental model of multiple sclerosis, by recruiting progenitors and channeling them into oligodendroglial lineage through administration of thyroid hormone (T4).
A large number of proliferating cells (BrdUrd uptake and Ki67-IR) and the expression of markers for undifferentiated precursors (nestin) increased in the subventricular zone and spinal cord of experimental allergic encephalomyelitis animals.
T4 administration reduces proliferation and nestin-immunoreactivity and up-regulates expression of markers for oligodendrocyte progenitors [polysialylated-neural cell adhesion molecule (PSA-NCAM), O4, A2B5] and mature oligodendrocytes (myelin basic protein) in the spinal cord, olfactory bulb, and subventricular zone.