More MS news articles for Mar 2002

The practical synthesis of vitamin D analogs: a challenge for process research

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11899621&dopt=Abstract

Curr Opin Drug Discov Devel 2001 Nov;4(6):808-33
Kabat MM, Radinov R.
Hoffmann-La Roche Inc, Chemical Synthesis-Process Research, Non-Clinical Development, Pre-Clinical Research and Development, Nutley, NJ 07110, USA.

New, highly-potent vitamin D analogs have increasingly come under consideration for the treatment of a variety of diseases as diverse as psoriasis, diabetes, renal osteodystrophy, osteoporosis, leukemia, cancer (breast, colon, prostate), AIDS and multiple sclerosis.

This review will present recent efforts for the development of practical syntheses of these valuable compounds using the synthetically convergent Lythgoe approach.