Eur Radiol 2002 Mar;12(3):559-67
Tan L, Pouwels W, van Schijndel A, Ader J, Manoliu A, Barkhof F.
MR Centre for MS research, VU Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
The application of image registration and subtraction to detect change in multiple sclerosis (MS) disease burden on serial MR scans benefits from the use of isotropic voxels.
An optimised 3D fast fluid-attenuated inversion recovery (FLAIR) sequence with 1.2- and 1.8-mm cubic voxels was compared with a 2D T2 SE sequence using standard 3-mm slices.
Three-dimensional fast FLAIR and T2 SE series were obtained in 20 MS patients and 15 controls.
Whole brain acquisition times for the 1.2- and 1.8-mm FLAIR were 21 and 10.5 min, respectively, for the interleaved T2 SE 16 min.
Brain lesions were marked in consensus by two radiologists and the CNR was calculated in ten lesions.
The mean number of lesions detected with the 1.2-mm FLAIR sequence was 115plus minus76, compared with 85plus minus59 for the T2 SE series ( p<0.001).
The 1.8-mm FLAIR detected only 73plus minus46 lesions. The CNR of the 1.2-mm FLAIR was significantly better than the T2 SE ( p<0.01), but not as good as the 1.8-mm FLAIR.
In conclusion, isotropic 3D fast FLAIR using 1.2-mm cubic voxels is superior to the 2D T2 SE in the detection of brain lesions in MS patients.
The isotropic 1.8-mm FLAIR is faster and has better contrast characteristics but lacks sensitivity.