Acta Neurol Scand 2002 Mar;105(3):158-63
Izquierdo G, Angulo S, Garcia-Moreno JM, Gamero MA, Navarro G, Gata JM, Ruiz-Pena JL, Paramo MD.
Servicio de Neurologia, Hospital Universitario Virgen Macarena, Sevilla, Spain, Servicio de Bioquimica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
We study the power of IgG synthesis value as a marker of disease activity in multiple sclerosis (MS).
Material and methods
Link index was calculated in 202 MS patients. Time between first, second and third attack and progression index (PI) were compared in patient with normal (NLI) high (HL) or very high Link index (VHLI).
Secondary progressive (SP) patients had a higher LI than relapsing--remitting (RR) and primary progressive (PP) courses (1.10 plus minus 0.5 for SP vs 0.86 plus minus 0.5 for RR and 0.81 plus minus 0.5 for PP, P=0.01 and 0.03, respectively). Having a HLI in MS RR and SP patients has no time effect in the development of the second and third attack. PI was higher in patients with VHIL (0.67 plus minus 0.7) vs patients with NLI (0.42 plus minus 0.4, P=0.008) and with HLI (0.39 plus minus 0.3, P=0.001).
This study confirmed that LI is a good marker of subsequent progression of MS.