June 8th, 2004
Boston Cure Project
Researchers at Yale, the Veterans Administration (VA) and University College London examined postmortem spinal cord tissue from patients with a progressive form of MS. Using biomarkers of the damaged nerve fibers, they looked for molecular abnormalities and found a strong link between nerve damage and the presence of two molecules, Nav. 1.6 and NCX, a sodium channel and a sodium-calcium exchanger.
"These results are extremely exciting because they provide, for the
first time, important clues about the molecular basis for permanent and
irreversible damage in MS," said Stephen Waxman, M.D., the lead investigator,
chair of neurology and director of the VA Rehabilitation Research and Development
Center in West Haven.
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