Clin Neurol Neurosurg. 2004 Jun;106(3):172-4
Department of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver Coastal Health Authority-UBC Hospital, G-920, Detwiller Pavilion, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5.
There is increasing evidence that the etiology of MS is heterogeneous.
MS is often described as a "disease waiting to happen".
The pathogenesis of the critical transition to clinical disease according to diagnostic criteria is largely unknown.
The role of environment and chance must also be considered.
Implications for counselling "at risk" individuals, based on family history, are discussed.