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More MS news articles for June 2004

Axonal damage in multiple sclerosis patients with high versus low expanded disability status scale score

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15198448

Can J Neurol Sci. 2004 May;31(2):225-8
Brass SD, Narayanan S, Antel JP, Lapierre Y, Collins L, Arnold DL.
Montreal Neurological Hospital, Department of Neurology and Neurosurgery, Montreal, Quebec, Canada.

BACKGROUND:

The pathophysiological basis for differences in disability in patients with multiple sclerosis is unclear.

METHODS:

We used magnetic resonance imaging to examine whether differences in disability in cohorts of multiple sclerosis patients with similar T2-weighted lesion volume and disease duration were associated with a more destructive disease process in the more disabled patients.

RESULTS:

The benign and severely disabled groups had similar brain atrophy metrics and similar decreases of the neuronal marker, N-acetylaspartate, in the normal appearing white matter of the cerebrum on magnetic resonance spectroscopy examination in vivo.

The severely disabled cohort had more spinal cord atrophy.

CONCLUSION:

The dissociation of spinal cord atrophy and cerebral atrophy between these two groups suggests that the difference between the more benign and more disabled groups cannot be explained by a more aggressive pathological process that is affecting the entire neuroaxis in a homogeneous fashion.