Neurology. 2004 Jun 8;62(11):2092-4
Lampasona V, Franciotta D, Furlan R, Zanaboni S, Fazio R, Bonifacio E, Comi G, Martino G.
Department of Clinical Chemistry, University Vita-Salute, San Raffaele Scientific Institute, Milan, Italy.
The authors used a liquid-phase radiobinding assay to measure serum anti-myelin oligodendrocyte protein (MOG) immunoglobulin (Ig) G in 87 patients with multiple sclerosis (MS), in 12 patients with encephalomyelitis, and in 47 healthy subjects.
Anti-MOG IgM was determined in samples obtained at onset from 40 of 87 patients with MS and in control subjects.
The frequency of positive samples with low titers of anti-MOG IgG (< or =5.7%) and IgM (< or =8.3%) was similar in all the groups and subgroups.
Binding competition experiments showed that these antibodies had low affinity.
Anti-MOG antibodies are not disease specific.