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More MS news articles for June 2004

Immunological Unresponsiveness Characterized by Increased Expression of CD5 on Peripheral T Cells Induced by Dendritic Cells In Vivo

Immunity. 2004 Jun;20(6):695-705
Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC.
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021 USA.

In the steady state, interaction between T cells and antigen-presenting dendritic cells (DCs) leads to T cell tolerance.

To examine the role of DC regulated peripheral tolerance in a model autoimmune disease, we delivered an encephalitogenic oligodendrocyte glycoprotein (MOG) peptide to DCs in vivo.

We found that targeting MOG peptide to DCs resulted in a novel form of peripheral T cell tolerance that was sufficiently profound to prevent autoimmune experimental acute encephalomyelitis (EAE).

The tolerized T cells were severely impaired in specific secondary responses to antigen in vivo but they were not intrinsically anergic since they remained highly responsive to T cell receptor (TCR) stimulation in vitro.

The mechanism that mediates this dynamic antigen-specific T cell unresponsiveness differs from previously described forms of tolerance in that it requires that DCs induce CD5 expression on activated T cells.