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More MS news articles for June 2004

Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes

Eur J Immunol. 2004 Jul;34(7):1828-38
Greve B, Reddy J, Waldner HP, Sobel RA, Kuchroo VK.
Center for Neurologic Diseases, Harvard Institutes of Medicine, Brigham and Women's Hospital, Boston, USA.

Nonobese diabetic (NOD) mice develop multi-organ autoimmune diseases, including type 1 diabetes.

We hypothesized that backcrossing the MHC region from SJL (H-2(s)) mice, which have an endogenous PLP(139-151)-reactive repertoire, onto the background of autoimmune-prone NOD mice would result in a mouse strain that is highly susceptible to experimental autoimmune encephalomyelitis (EAE).

Unexpectedly, although we detected an endogenous PLP(139-151) repertoire in the NOD.S mice, they did not develop spontaneous EAE and were relatively resistant to PLP(139-151)-induced EAE when compared to SJL mice.

This resistance was associated with lower production of proinflammatory cytokines and a decreased expansion of PLP(139-151)-specific CD4(+) T cells after immunization and restimulation with PLP peptide in vitro.

Vbeta chain usage among PLP(139-151)-reactive T cells differed between SJL and NOD.S mice.

Furthermore, NOD.S mice were resistant to the development of insulitis and cyclophosphamide-induced diabetes, but not sialadenitis.

Altogether, even though NOD mice develop spontaneous autoimmune diseases, they become relatively resistant to induction of EAE even when they express the EAE-permissive class II molecule I-A(s).

Our data show that certain combinations of otherwise susceptibility-conferring MHC and non-MHC genes can mediate autoimmune-disease resistance when they are paired together.

These findings do not support the "shared autoimmune gene" hypothesis.