Magn Reson Med. 2003 Jul;50(1):201-5
Bulte JW, Ben-Hur T, Miller BR, Mizrachi-Kol R, Einstein O, Reinhartz E, Zywicke HA, Douglas T, Frank JA.
Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases.
Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high-resolution (microscopic) MR images were obtained ex vivo.
Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology.
The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols.