All About Multiple Sclerosis

More MS news articles for June 2003

Diverse Targets for Intervention during Inflammatory and Neurodegenerative Phases of Multiple Sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12797954&dopt=Abstract

Neuron. 2003 Jun 5;38(5):685-8
Zamvil SS, Steinman L.
Department of Neurology, University of California, San Francisco, 94143, San Francisco, CA, USA

Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating disease that causes relapsing and chronic neurologic impairment.

Recent observations have altered certain traditional concepts regarding MS pathogenesis.

A greater diversity of cell types and molecules involved in MS is now evident.

While remyelination can occur during the early inflammatory phase when damage may be reversible, it is impaired in the later stages, which involve axonal death.

These observations have important therapeutic implications.