J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):953-955
Ramsaransing G, Teelken A, Prokopenko VM, Arutjunyan A, De Keyser J.
Department of Neurology, Academisch Ziekenhuis Groningen, Groningen, Netherlands Laboratory of Perinatal Biochemistry, D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, Russia.
The gene for myeloperoxidase (MPO) has been implicated in multiple sclerosis (MS).
By measuring H(2)O(2) dependent oxidation of 3,3'5,5'-tetramethylbenzidine with spectrophotometry the authors investigated MPO activity in peripheral blood leucocytes from 42 patients with MS (12 with secondary progressive MS, 17 with primary progressive MS, and 13 with relapsing remitting benign MS) and 32 healthy controls.
Leucocyte MPO activity was significantly lower in patients with benign MS (mean (SEM) 0.086 (0.029) U/mg protein; p<0.01), secondary progressive MS (0.038 (0.009) U/mg protein; p<0.001), and primary progressive MS (0.057 (0.016) U/mg protein; p<0.001) compared with healthy controls (0.322 (0.053) U/mg protein).
These data suggest that low MPO, which may be genetically determined, plays a part in MS pathogenesis.