All About Multiple Sclerosis

More MS news articles for June 2003

Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12783433&dopt=Abstract

Ann Neurol. 2003 Jun;53(6):819-22
Vogt MH, Lopatinskaya L, Smits M, Polman CH, Nagelkerken L.
Division of Immunological and Infectious Diseases, TNO Prevention and Health, Leiden.

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions.

Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients.

In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels.

Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses.