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More MS news articles for June 2003

Elevated osteopontin levels in active relapsing-remitting multiple sclerosis

Ann Neurol. 2003 Jun;53(6):819-22
Vogt MH, Lopatinskaya L, Smits M, Polman CH, Nagelkerken L.
Division of Immunological and Infectious Diseases, TNO Prevention and Health, Leiden.

In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions.

Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients.

In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels.

Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses.