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More MS news articles for June 2003

Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice

J Neuroimmunol. 2003 Jun;139(1-2):44-50
Voskuhl RR, Pribyl TM, Kampf K, Handley V, Liu H, Feng J, Campagnoni CW, Soldan SS, Messing A, Campagnoni AT.
Reed Neurological Research Center, UCLA Department of Neurology, 710 Westwood Plaza, 90095, Los Angeles, CA, USA

Increased golli MBP (golli) expression has been observed in the peripheral immune system of mice in the relapsing phase of EAE, raising the possibility that golli MBP expression in the periphery may contribute to relapses.

Here we describe the generation of golli MBP-deficient mice and a comparison of the clinical course of EAE between heterozygous (golli(+/-)) and wild-type (golli(+/+)) mice.

There was no difference between the two groups in incidence of disease, severity of the first episode of disease, or remission after the first episode.

However, there was a significant reduction in relapses in golli(+/-) mice vs. controls, suggesting a role for golli proteins in the relapses in EAE.