J Neuropathol Exp Neurol 2002 Jun;61(6):539-46
Peterson JW, Bo L, Mork S, Chang A, Ransohoff RM, Trapp BD.
Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA.
The distribution and lineage of vascular cell adhesion molecule-1 (VCAM-1)-positive cells was investigated in 43 lesions from the brain tissue of patients with multiple sclerosis (MS).
Numerous VCAM-1-positive macrophages/microglia were detected at the edges of MS lesions.
Quantitative analysis of 6 active, 7 chronic active, and 4 chronic inactive MS lesions identified most VCAM-1-positive cells at the actively demyelinating borders of active (102/mm3) and chronic active (29/mm3) lesions, but rarely in chronic inactive lesions (4/mm3).
Further, approximately 17% of the VCAM-1-positive cells closely apposed or surrounded oligodendrocyte perikarya at the edges of active and chronic active lesions that were sites of ongoing demyelination.
Endothelial cells were VCAM-1-negative in both lesion and non-lesion MS brain tissue.
This report is the first to document direct microglial interaction with oligodendrocytes in MS.