Annals of Neurology
Volume 51, Issue 6, 2002. Pages: 763-767
Erina M. Schumann, MD, Tania Kümpfel, MD, Florian Then Bergh, MD, Claudia Trenkwalder, MD, Florian Holsboer, MD, PhD, Dorothee P. Auer, MD *
Max Planck Institute of Psychiatry, Munich, Germany
The known interaction between the immune system and the hypothalamic-pituitary-adrenal axis led us to explore the interrelation between magnetic resonance imaging findings and the hypothalamic-pituitary-adrenal axis activity in 53 multiple sclerosis patients.
The cortisol release induced by the dexamethasone-corticotropin-releasing hormone test was negatively associated with the presence and number of gadolinium-enhancing lesions and positively associated with ventricular size.
This finding suggests a protective effect of the hypothalamic- pituitary-adrenal drive on acute lesional inflammation in multiple sclerosis, probably by limiting immune overshoot.
In contrast, the nature of the correlation between hypothalamic-pituitary-adrenal hyperdrive and brain atrophy remains to be determined.
Copyright © 1999-2002 by John Wiley & Sons, Inc