Curr Opin Neurol 2002 Jun;15(3):247-51
Wolinsky JS, Narayana PA.
Department of Neurology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis.
These include now well-recognized alterations of neuronal biochemical markers that accompany tissue destruction readily visualized by magnetic resonance imaging, but also dynamic changes in several metabolites that indicate pathological processes that precede the magnetic resonance imaging-defined lesion, or completely escape current high-resolution imaging.