Proc. Natl. Acad. Sci. USA, Vol. 99, Issue 13, 9031-9036, June 25, 2002
Peng Chen, David E. Goldberg, Bryan Kolb, Marc Lanser, and Larry I. Benowitz
Department of Neurosurgery, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115; Harvard Medical School, Boston, MA 02115; § Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada 11K 3M4; and Boston Life Sciences, Incorporated, 137 Newbury Street, Boston, MA 02116
Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization.
The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo.
We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord.
This growth was paralleled by improved performance on several behavioral measures.
Copyright © 2002 by the National Academy of Sciences