More MS news articles for June 2002

Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans

Blood 2002 Jul 1;100(1):174-7
Dhodapkar MV, Steinman RM.
Laboratory of Tumor Immunology and Immunotherapy and the Laboratory of Cellular Physiology and Immunology, Rockefeller University; New York, NY; and the Hematology Division, Memorial Sloan-Kettering Cancer Center, New York, NY.

Regulatory T cells (T(R)s) can suppress the function of other effector T cells in the setting of autoimmunity, transplantation, and resistance to tumors.

The mechanism for the induction of T(R)s has not been defined.

We previously reported that an injection of immature dendritic cells (DCs) pulsed with influenza matrix peptide (MP) led 7 days later to antigen-specific silencing of effector T-cell function in the blood of 2 healthy human subjects.

Here, we found that interferon-gamma-producing effectors return by 6 months.

Importantly, in mixing experiments, CD8(+) T cells from the sample obtained 7 days after injection could suppress MP-specific effectors obtained before injection and those in recovery samples.

This suppression or regulation was specific for the immunizing peptide (MP) and cell-dose dependent, and it required contact between the 2 samples.

These data show the capacity of immature DCs to induce antigen-specific regulatory CD8(+) T cells in humans.

(Blood. 2002;100:174-177)