J Neuroimmunol 2002 Jun;127(1-2):96-105
Calabresi PA, Yun SH, Allie R, Whartenby KA.
Department of Neurology, School of Medicine, University of Maryland, Room 12-027, 655 W. Baltimore St., 21201, Baltimore, MD, USA
Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles.
In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT).
Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNgamma, and inversely correlated with IL-5 production.
TT TCL had significantly higher expression of CCR7(-)/CD45RA(-) T effector memory (Tem) cells than MBP TCL.
However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype.
CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).