J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1145-7
Frisen L.
Institute of Clinical Neuroscience, Sahlgren's Academy of Goteborg
University, Sweden.
OBJECTIVE:
To investigate the state of spatial vision in visually asymptomatic subjects at high risk for multiple sclerosis.
METHODS:
Fifteen subjects suffering a first neurological episode suggestive of multiple sclerosis in clinical presentation, immunological profile, and magnetic resonance imaging, were examined with a new, sensitive test of spatial vision, rarebit perimetry.
None had symptoms or signs of optic neuropathy.
RESULTS:
Results of rarebit perimetry were significantly worse than those of 15 age matched normal controls (p=0.01); seven patients (47%) were outside normal limits.
One patient only obtained abnormal results in high pass resolution perimetry.
CONCLUSIONS:
Rarebit perimetry may help to close the sensitivity gap between clinical examinations and neuroimaging.