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More MS news articles for July 2003

Comparison of Multiple Sclerosis Lesions at 1.5 and 3.0 Tesla

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12821856&dopt=Abstract

Invest Radiol. 2003 Jul;38(7):423-427
Sicotte NL, Voskuhl RR, Bouvier S, Klutch R, Cohen MS, Mazziotta JC.
*Department of Neurology, dagger Division of Brain Mapping, double dagger Department of Molecular and Medical Pharmacology, section sign Department of Radiological Sciences, paragraph sign Department of Psychiatry and Biobehavioral Sciences, and parallel Department of Biomedical Physics, University of California Los Angeles, Los Angeles, CA. *Department of Neurology, dagger Division of Brain Mapping, double dagger Department of Molecular and Medical Pharmacology, section sign Department of Radiological Sciences, paragraph sign Department of Psychiatry and Biobehavioral Sciences, and parallel Department of Biomedical Physics, University of California Los Angeles, Los Angeles, CA.

OBJECTIVE

To evaluate the relative sensitivity of MR scanning for multiple sclerosis (MS) at 1.5 Tesla (T) and 3.0 T using identical acquisition conditions, as is typical of multicenter clinical trials.

METHODS

Twenty-five subjects with MS were scanned at 1.5 T and 3.0 T using fast spin echo, and T(1)-weighted SPGR with and without gadolinium contrast injections.

Image data, blinded to field strength, were analyzed using automated segmentation and lesion counting.

RESULTS

Relative to scanning at 1.5 T, the 3.0 T scans showed a 21% increase in the number of detected contrast enhancing lesions, a 30% increase in enhancing lesion volume and a 10% increase in total lesion volume.

DISCUSSION

The improved detection ability using high-field MR imaging is prominent even when sequence parameters are optimized around the midfield units.

Multicenter trials using both 1.5 T and 3.0 T instruments may be affected by these sensitivity differences.